A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Yi-Xuan Wang - Top 30 Publications

A homozygous missense variant in HSD17B4 identified in a consanguineous Chinese Han family with type II Perrault syndrome.

Perrault syndrome is a rare multisystem disorder that manifests with sensorineural hearing loss in both sexes, primary ovarian insufficiency in females and neurological features. The syndrome is heterogeneous both genetically and phenotypically.

Associations between cognitive impairment and motor dysfunction in Parkinson's disease.

Numerous studies have been carried out to explore the potential association between neurologic deficits and variable clinical manifestations of Parkinson's disease (PD). The aim of our study was to investigate the association between cognitive performance and motor dysfunction in Chinese patients with PD.

Olfaction in Parkin carriers in Chinese patients with Parkinson disease.

Olfactory identification was reported to be better among PD (Parkinson disease) patients with Parkin mutations, but previous studies didn't eliminate the interference of other PD related genes on olfaction, and whether olfaction of Parkin mutations patients was better in Chinese population was still unknown.

Structural Insights Into 9-Styrylanthracene-Based Luminophores: Geometry Control Versus Mechanofluorochromism and Sensing Properties.

Organic luminophores have been increasingly applied in various fields and the corresponding structural studies are emerging as hot topics, which supply essential information on the relationships between molecular structures and photophysical properties. Herein, a series of 9-styrylanthracene-based luminophores with different geometries (symmetrical DTVA, asymmetrical TVA and CPVA) were facilely synthesized for a systematical photophysical invesitigation. The targets display reversible and diverse mechanofluorochromism in the solid state. In particular, DTVA and TVA exhibit an obviously higher solid-state fluorescence quantum efficiency and distinctive AIE-active behavior, with contrary emission shifts under external force. Moreover, DTVA and TVA showed high sensitivity for detection of picric acid (PA) in aggregated states. This study may be helpful to reveal the structural essence of luminesecent materials and pave the way to the development of novel functional luminophores.

The heterozygous R1441C mutation of leucine-rich repeat kinase 2 gene in a Chinese patient with Parkinson disease: A five-year follow-up and literatures review.

Leucine-rich repeat kinase 2 gene (LRRK2) was recognized associated with both familial and sporadic Parkinson Disease (PD). Seven missense mutations (G2019S, R1441C, R1441G, R1441H, Y1699C, I2020T, N1437H) of it have been confirmed disease- causing. They were common among Caucasian PD patients, but rarely reported in Asian, especially in Chinese Han population.

p-Quaterphenylene as an Aggregation-Induced Emission Fluorogen in Supramolecular Organogels and Fluorescent Sensors.

Two dumbbell-shaped organogelators with a p-quaterphenylene core were synthesized, and their self-assembly properties were investigated. These low-molecular-weight gelators could form self-supporting gels in many apolar organic solvents with an H-type aggregation form through a synergic effect of π-π stacking, intermolecular translation-related hydrogen bonding, and van der Waals forces. In comparison to the p-terphenylene-cored gelator, the extended π-conjugated segment improved the gelation efficiency significantly with enhanced gelation rate. Additionally, these p-quaterphenylene-centered gelators exhibited strong fluorescence emission induced by aggregation, which not only provided an in situ method to optically monitor the gelation process, but also endowed these self-assemblies with substantial applications in sensing explosives.

Odor Identification Test in Idiopathic REM-Behavior Disorder and Parkinson's Disease in China.

Olfactory dysfunction is common in Parkinson's disease (PD) and idiopathic rapid eye movement sleep behavior disorder (iRBD), which is a risk factor in the development of PD. However, a few studies have conflicting results when comparing dysosmia in the patients with iRBD and PD. There is no study investigating the olfactory function in Chinese patients with iRBD. Additionally, the Sniffin' Sticks screening 12 test (SS-12) contains several odors that are not familiar to people in different cultures.

Facilitated biological reduction of nitroaromatic compounds by reduced graphene oxide and the role of its surface characteristics.

How reduced graphene oxide (RGO) mediates the reductive transformation of nitroaromatic pollutants by mixed cultures and the role of its surface characteristics were evaluated in this study. Different electron donors were applied to investigate the interaction between RGO and anaerobic microbes. Moreover, the influence of the surface properties of RGO on biological nitroaromatic removal was further elucidated. The results show that RGO could achieve an approximate one-fold rate increase of nitrobenzene reduction by mixed culture with glucose as an electron donor. Selective elimination of oxygen moieties on the RGO surface, such as quinone groups, decreased the nitrobenzene transformation rate, whereas doping nitrogen into the RGO framework exhibited a positive effect. The study indicates that graphene-based carbon nanomaterials have the potential to accelerate the biological transformation of nitroaromatic compounds and that the functionalization of these carbon nanomaterials, especially through surface modification, would further enhance the conversion efficiency of contaminants.

Removal of halogenated emerging contaminants from water by nitrogen-doped graphene decorated with palladium nanoparticles: Experimental investigation and theoretical analysis.

The removal performance and mechanisms of halogenated emerging contaminants from water by palladium decorated nitrogen-doped graphene (Pd/NG) were investigated in this study. For comparison, three catalysts of Pd/NG, palladium decorated graphene (Pd/G) and commercial Pd/C were initially explored to degrade tetrabromobisphenol A (TBBPA). After that, the influence of various environmental parameters on TBBPA removal by the Pd/NG catalyst was evaluated. Moreover, both Langmuir-Hinshelwood model and density functional theory (DFT) were adopted to theoretically elucidate the adsorption and the activation of TBBPA on the catalyst. The results show that the apparent rate constant of TBBPA dehalogenation was increased by 26.7% and 39.0% in the presence of the Pd/NG catalyst compared to the Pd/G and Pd/C ones. Higher temperature, catalyst dosage and alkaline conditions resulted in the enhancement of TBBPA dehalogenation by the Pd/NG catalyst, while humic acid in the solution had a negatively effect on the transformation of TBBPA. The corresponding rate constant value exhibited a 2.1- and 1.8-fold increase with the rise of temperature from 298 to 328 K and initial pH from 6.5 to 9.0, respectively. On the contrary, the rate constant was decreased by 78.9% in the presence of 15 mg L(-1) humic acid. Theoretical analysis revealed that both adsorption and activation processes of TBBPA on the Pd/NG catalyst were enhanced through the N doping into graphene framework.

Identification of original species of Mantidis Oötheca (Sangpiaoxiao) based on DNA barcoding.

Both market research and literature reports both found that the ootheca of mantodea was all used as medicine. However, Chinese Pharmacopoeia only records the ootheca of three mantis species. The clinical use of ootheca unrecorded in Chinese Pharmacopoeia, will pose potential risks to drug safety. It's urgent to identify the origin of Mantidis Oötheca. The current researches about original animal in Mantidis Oötheca are based on morphology and unanimous. DNA barcoding fill gaps of the traditional morphological identification, which is widely used in animal classification studies. This study first use DNA barcoding to analyze genetic distance among different Mantidis Oötheca types, align COI sequences between mantis and Mantidis Oötheca and construct the phylogeny tree. The result confirmed that Tenodera sinensis and Hierodula patellifera were the origin insects of Tuanpiaoxiao and Heipiaoxiao, respectively, and Statilia maculate and Mantis religiosa were the origin insects of Changpiaoxiao.

Onset-related subtypes of Parkinson's disease differ in the patterns of striatal dopaminergic dysfunction: A positron emission tomography study.

The young-onset subtype of Parkinson's disease (YOPD) differs from the late-onset subtype (LOPD) in drug responsiveness, incidence of motor complications, and prognosis. The pathophysiology underlying these differences remains largely unknown. This study investigated whether the two subtypes differ in the pattern of dysfunction in striatal (caudate and putamen) dopaminergic system and if the dopamine transporter (DAT) imaging patterns are associated with the clinical features of corresponding PD subtype.

Effects of tamoxifen on CD147 glycosylation and MMPs in the diabetic rat myocardium.

Over the last few decades, diabetic cardiomyopathy has been identified as a significant contributor in cardiac morbidity. However, the mechanisms of diabetic cardiomyopathy have not been clarified.

Photolysis of an amphiphilic assembly by calixarene-induced aggregation.

Photosensitizers generally show great tendency for self-aggregation in aqueous media, leading to quenched fluorescence and lower photosensitizing ability. Herein, we report that amphiphilic anthracene is highly photoreactive after aggregation induced by p-sulfonatocalix[4]arene in water. The formation of a host-guest supramolecular assembly and the photolysis of the anthryl core are identified by UV-vis and NMR spectroscopy, dynamic light scattering, and transmission electron microscopy. Additionally, the assembly exhibited efficient photolysis with visible light in the presence of exogenous photosensitizers. This approach could be extended to various photoresponsive self-assemblies and applications in phototherapy and the design of photodegradable materials.

Amphiphilic p-sulfonatocalix4arene as "drug chaperone" for escorting anticancer drugs.

Supramolecularly constructing multifunctional platform for drug delivery is a challenging task. In this work, we propose a novel supramolecular strategy "drug chaperone", in which macrocyclic amphiphiles directly coassemble with cationic drugs into a multifunctional platform and its surface is further decorated with targeting ligands through host-guest recognition. The coassembling and hierarchical decoration processes were monitored by optical transmittance measurements, and the size and morphology of amphiphilic coassemblies were identified by dynamic light scattering and high-resolution transmission electron microscopy. In cell experiments to validate the drug chaperone strategy, the anticancer activities of free drugs were pronouncedly improved by coassembling with amphiphilic chaperone and further functionalization with targeting ligand.

Autophagy involvement in olanzapine-mediated cytotoxic effects in human glioma cells.

The aim of this study was to investigate the effects of olanzapine on growth inhibition as well as autophagy in glioma cells in vitro and in vivo. The proliferation of both LN229 and T98 glioma cells, measured by MTT assay, was suppressed in a concentration-dependent and time-dependent manner. Moreover, apoptosis of both cells was significantly increased with the treatment of olanzapine as evidenced by increased Bcl-2 expression, Hoechst 33258 staining and annexinV-FITC/PI staining. Olanzapine treatment also enhanced activation of autophagy with increased expression of LC3-II, expression of protein p62, a substrate of autophagy, being decreased. The growth inhibition by olanzapine in both glioma cell lines could be blocked by co-treatment with 3-MA, an autophagy inhibitor. Furthermore, olanzapine effectively blocked the growth of subcutaneous xenografts of LN229 glioma cells in vivo. The increased level of protein LC3-II and decreased level of p62 followed by a decreased level of Bcl-2, suggesting that autophagy may contribute to apoptosis. In addition, reduced proliferation of glioma cells was shown by a decrease of Ki-67 staining and increased caspase-3 staining indicative of apoptosis in mouse xenografts. These results indicated that olanzapine inhibited the growth of glioma cells accompanied by induction of autophagy and apoptosis both in vitro and in vivo. Olanzapine-induced autophagy plays a tumor-suppressing role in glioma cells.

Effect of Fe2+ on fermentation hydrogen production in an UASB.

Fe2+ has an important effect on the production of hydrogen in a biological way. With the brown sugar as the substrate, the effect of biotechnology hydrogen production capacity of the Fe2+ concentration ranging from 0-1650 mg x L(-1) on the condition of anaerobic fermentation was studied. The results showed that appropriate divalent ions had the ability to enhance the hydrogen production. Biogas amounts and hydrogen content increased with increasing Fe2+ concentration from 0-450 mg x L(-1). Compared with the control group increased by 40.75%, the maximum biogas amount of 17.72 L was obtained at Fe2+ concentration of 450 mg x L(-1). And at the same time, the hydrogen content was 60.01 percent. Biogas amounts and hydrogen content decreased gradually when the concentration of Fe2+ was higher than 450 mg x L(-1). Therefore Fe2+ is one of important engineering parameters for the fermentative hydrogen production.

Enzyme-responsive supramolecular polymers by complexation of bis(p-sulfonatocalixarenes) with suberyl dicholine-based pseudorotaxane.

A linear supramolecular ternary polymer was fabricated by iteratively threading cyclodextrin with suberyl dicholine and end-capping with bis-calixarenes, showing desired cholinesterase response.

Electricity generation performance of two-chamber microbial full cell in the treatment of simulated wastewater.

The start-up procedures, the degradation efficiency of organics at the anode and the removal efficiency of Cu2+ at the cathode of the cell were studied, based on which the performance of MFC (microbial fuel cell) in electricity generation and wastewater treatment was evaluated. A simple two-chamber microbial fuel cell was established with simulated molasses wastewater as substrate at the anode and simulated electroplating wastewater as an electron acceptor at the cathode. The results from a batch of experiments showed that the highest voltage output of 417.00 mV was obtained at an external resistance of 800 Omega, and that the maximum power density of 44.17 mW x m(-2) was obtained with an internal resistance of 293 Omega based on the polarization curve. In addition, COD removal rate reached its highest value (47.31%) in the fifth cycle, and the maximum removal rate (59.76%) for Cu2+ was recorded in the fourth cycle. In summary, the application of MFC in the treatment of organic wastewater and electroplating wastewater is feasible.

Synthesis of core/shell structured magnetic carbon nanoparticles and its adsorption ability to chlortetracycline in aquatic environment.

Magnetic carbon nanoparticles with core/shell structure (Fe3C/[email protected]) and large surface areas were synthesized via hydrothermal method followed with heat treatment under N2 atmosphere. The adsorbent has strongly magnetic cores and graphitized carbon shell. The removal efficiency of chlortetracycline (CTC) from aquatic environment by Fe3C/[email protected] was investigated. The results showed that Fe3C/[email protected] exhibited ultrahigh adsorption ability to CTC. The adsorption behavior of CTC on FeC/[email protected] fitted the pseudo-second-order kinetic model, and the adsorption equilibrium was achieved within 24 h. The adsorption ability of CTC increased with solution pH at pH 3.5-7.5, but decreased with further increase of pH (pH 7.5-8.5). CTC adsorption decreased with solution temperature and increased with ionic strength. As the concentration of coexisting humic acid in solution ranged in 10-50 mg x L(-1), the adsorption ability of CTC on Fe3C/[email protected] was only decreased by 10%-20%. Under the optimal conditions (pH = 7.5, T = 293 K), the maximum adsorption capacity of CTC on Fe3C/[email protected] calculated by Langmuir was 909 mg x g(-1), which was significantly higher than those obtained on sediment or minerals. More importantly, Fe3C/[email protected] adsorbed with CTC can be collected from water sample under a magnetic field rapidly for special disposal, which avoids secondary pollution of water. These results indicate that Fe3C/[email protected] is a potentially efficient, green adsorbent for removal of tetracycline antibiotics from aquatic environment.

Cholinesterase-responsive supramolecular vesicle.

Enzyme-responsive, amphiphilic self-assembly represents one of the increasingly significant topics in biomaterials research and finds feasible applications to the controlled release of therapeutic agents at specific sites where the target enzyme is located. The supramolecular approach, using "superamphiphiles", provides a smart way to fabricate drug delivery systems responsive to enzymatic catalysis. In this work based on the concept of supramolecular chemistry, we report an enzyme-responsive vesicle using p-sulfonatocalix[4]arene as the macrocyclic host and natural enzyme-cleavable myristoylcholine as the guest molecule. The complexation of p-sulfonatocalix[4]arene with myristoylcholine directs the formation of a supramolecular binary vesicle, which is dissipated by cholinesterase with high specificity and efficiency. Cholinesterase is a key protein overexpressed in Alzheimer's disease, and therefore, the present system may have potential for the delivery of Alzheimer's disease drugs.

Degradation of norfloxacin by nano-Fe3O4/H2O2.

The degradation of norfloxacin in aquatic environment was studied in the presence of Fe3O4 nanoparticles and H2O2. The effects of solution pH, temperature, dose of catalysts and concentration of H2O2 on norfloxacin degradation were surveyed. The degradation behaviors of different substrates by nano-Fe3O4/H2O2 were investigated and the reaction mechanism of norfloxacin was discussed. The results showed that the reaction was strongly pH-dependent and favored in acidic solution (pH = 3.5). The removal efficiency of norfloxacin was enhanced with the increase of temperature, catalysts dosage and H2O2 concentration. The degradation efficiency of norfloxacin by nano-Fe3O4/H2O2 was significantly higher than those of sulfathiazole, phenolic and aniline compounds. In the presence of 4.4 mmol x L(-1) of H2O2, 0.80 g x L(-1) of Fe3O4 and T = 303 K, norfloxacin was degraded completely in 5 min. The F element in norfloxacin molecule existed totally as F(-) in solution within 5 min, and the removal efficiency of total organic carbon was 57% in 1 h. In the ESR spectrum of nano-Fe3O4/H2O2 system, the characteristic peaks of BMPO-*OH adduct was detected, however, the intensity of the peaks was reduced to 5% with the addition of tert-butanol, a strong *OH scavenger, and the degradation efficiency of norfloxacin was correspondingly decreased to 10% in 1 h. These results indicated that *OH played an important role on norfloxacin degradation, and the reaction proceeded based on a heterogeneous Fenton-like system.

A multiplex model of combining gene-based, protein-based, and metabolite-based with positive and negative markers in urine for the early diagnosis of prostate cancer.

Multiplex urine-based assay emerged outperforms single biomarker (e.g., prostate-specific antigen, PSA) for predicting prostate cancer (CaP), whereas its combined mode has to be fully optimized. Our aim is to determine whether a strategy of combining gene-based, protein-based, metabolite-based with positive, negative makers in urine could optimize a multiplex model for detecting CaP.