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sexually transmitted diseases - Top 30 Publications

Articular Cartilage Aging-Potential Regenerative Capacities of Cell Manipulation and Stem Cell Therapy.

Changes in articular cartilage during the aging process are a stage of natural changes in the human body. Old age is the major risk factor for osteoarthritis but the disease does not have to be an inevitable consequence of aging. Chondrocytes are particularly prone to developing age-related changes. Changes in articular cartilage that take place in the course of aging include the acquisition of the senescence-associated secretory phenotype by chondrocytes, a decrease in the sensitivity of chondrocytes to growth factors, a destructive effect of chronic production of reactive oxygen species and the accumulation of the glycation end products. All of these factors affect the mechanical properties of articular cartilage. A better understanding of the underlying mechanisms in the process of articular cartilage aging may help to create new therapies aimed at slowing or inhibiting age-related modifications of articular cartilage. This paper presents the causes and consequences of cellular aging of chondrocytes and the biological therapeutic outlook for the regeneration of age-related changes of articular cartilage.

Examination of Behavioral, Social, and Environmental Contextual Influences on Sexually Transmitted Infections in At Risk, Urban, Adolescents and Young Adults.

Despite the large body of extant literature on sexually transmitted infections (STIs) in adolescents and young adults (AYAs), more research on social and environmental contextual factors is needed. Also, further examination of STI indicators by gender remains a critical area of research focus.

An illustration of the potential health and economic benefits of combating antibiotic resistant gonorrhea.

Preventing the emergence of ceftriaxone-resistant Neisseria gonorrhoeae can potentially avert hundreds of millions of dollars in direct medical costs of gonorrhea and gonorrhea-attributable HIV infections. In the illustrative scenario we examined, emerging ceftriaxone resistance could lead to 1.2 million additional N. gonorrhoeae infections over 10 years, costing $378.2 million.

Integration of Contact Tracing and Phylogenetics in an Investigation of Acute HIV Infection.

The integration of traditional contact tracing with HIV sequence analyses offers opportunities to mitigate some of barriers to effective network construction. We utilized combined analyses during an outbreak investigation of spatiotemporally clustered acute HIV infections to evaluate if the observed clustering was the product of a single outbreak.

Improving insurance and healthcare systems to ensure better access to sexually transmitted disease testing and prevention.

Creating Innovative STI Testing Options for University Students: the Impact of an STI Self-testing Program.

National-level data suggest that STI testing rates among young adults are low. The purpose of this study was to evaluate the acceptability of an STI self-testing program at a university health center. Few evaluations have been conducted on the acceptability of collegiate self-testing programs and their effect on testing uptake.

Non-Vaccine-Type HPV Prevalence after Vaccine Introduction: No Evidence for Type Replacement but Evidence for Cross-Protection.

We examined non-vaccine-type HPV prevalence in a community before and over the first eight years after vaccine introduction, to assess for 1) type replacement with any non-vaccine type HPV and 2) cross-protection with non-vaccine types genetically related to vaccine-type HPV.

Gonococcal and Chlamydial Cases of Pelvic Inflammatory Disease at two Canadian STI Clinics, 2004-2014; A Retrospective Cross-sectional Review.

One hundred and thirteen patients with gonococcal (NG) and chlamydial (CT) PID were reviewed at two Canadian STI clinics. The majority (81%) of patients with PID were diagnosed with CT alone. Three treatment failures (TF) were seen in patients treated with ofloxacin.

An Exploration of Factors Impacting Pre-exposure Prophylaxis Eligibility and Access among Syringe Exchange Users.

In 2015 approximately 50,000 new HIV infections occurred in the United States, 2,400 of which were attributable to injection drug use in. Pre-exposure prophylaxis (PrEP) has the potential to curb HIV acquisition, however, uptake remains low among persons who inject drugs (PWID). The purpose of the study is to describe PrEP eligibility, willingness to use PrEP, and ability to access PrEP among PWID recruited from a pilot program that paired screening and treatment for sexually transmitted infections with mobile syringe exchange program (SEP) services.

Narrative Review: Assessment of Neisseria gonorrhoeae Infections Among Men Who Have Sex with Men in National and Sentinel Surveillance Systems in the United States.

To assess trends in Neisseria gonorrhoeae among gay, bisexual, and other men who have sex with men (MSM), we reviewed existing and published gonorrhea surveillance data in the United States (U.S.). Data identified in this review include: national gonorrhea case report data and data from three other surveillance programs, the Gonococcal Isolate Surveillance Project (GISP), the STD Surveillance Network (SSuN), and National HIV Behavioral Surveillance (NHBS).Rates of reported cases of gonorrhea among men increased 54.8% during 2006-2015 compared to a 2.6% increase among women. Since 2012, the rate of reported gonorrhea cases among men surpassed the rate among women; the male-to-female case rate ratio increased from 0.97 in 2012 to 1.31 in 2015. The proportion of gonococcal urethral isolates collected in GISP that were collected from MSM increased from 21.5% to 38.1% during 2006-2015. During 2009-2015, the percent of MSM who tested positive for rectal and oropharyngeal gonorrhea in STD clinics increased by 73.4% and 12.6%, respectively. Estimated rates of gonorrhea among MSM increased 151% during 2010-2015 in jurisdictions participating in SSuN. Data from NHBS demonstrate that testing for gonorrhea among MSM increased 23.1% between 2011 and 2014.Together, surveillance data suggest a disproportionate burden of gonorrhea among MSM in the U.S. and suggest increases in both screening and disease in recent years. Since each data source has inherent limitations and biases, examining these data from different systems together strengthens this conclusion.


Sexually transmitted infection (STI) rates are increasing in the U.S. while funding for prevention and treatment programs has declined. Sample self-collection for STI testing in men may provide an acceptable, easy, rapid and potentially cost-effective method for increasing diagnosis and treatment of STIs.


Users (index patients with a verified STI and notified partners) rated the health care provider initiated Internet-based partner notification application acceptable and usable. Both groups were less positive about to notify /get notified of HIV than of other STI. An anonymous notification was perceived less acceptable.

Early evidence of the effectiveness of the human papillomavirus vaccination program against anogenital warts in Manitoba, Canada: A registry cohort study.

We assessed the effectiveness of the qHPV vaccination program in Manitoba, Canada in reducing incident AGWs, and to what extent effectiveness depends on age at vaccination, and number of doses.

Enhanced Molecular Typing of Treponema pallidum subsp. pallidum strains from four Italian hospitals shows geographical differences in strain type heterogeneity, widespread resistance to macrolides, and lack of mutations associated with doxycycline resistance.

Although syphilis rates have been relatively high in Italy for over 15 years, no data on the molecular types of Treponema pallidum subsp. pallidum (T. pallidum) circulating in this country are yet available. Likewise, no data exist on how widespread is resistance to macrolide or tetracycline antibiotics in these strains. Such data would however promote comprehensive studies on the molecular epidemiology of syphilis infections in Italy and inform future interventions aiming at syphilis control in this and other European countries.

High Baseline Anal HPV and Abnormal Anal Cytology in a Phase 3 Trial of the Quadrivalent HPV Vaccine in HIV-infected individuals over 26 years old: ACTG 5298.

The quadrivalent human papillomavirus (HPV) vaccine (qHPV; types 6, 11, 16, 18) is indicated for men and women 9-26 years to prevent HPV associated anogenital high grade squamous intraepithelial lesions (HSIL) and cancer. ACTG 5298 was a randomized placebo controlled Phase 3 study in HIV-infected men who have sex with men (MSM), and women of qHPV to prevent persistent anal HPV infection. Baseline data is presented here.

Integrated Hepatitis C Testing and Linkage to Care at a Local Health Department STD Clinic: Determining Essential Resources and Evaluating Outcomes.

Guidance about integration of comprehensive hepatitis C virus (HCV)-related services in sexually transmitted disease (STD) clinics is limited. We evaluated a federally-funded HCV testing and linkage-to-care program at an STD clinic in Durham County, North Carolina. During December 10, 2012-March 31, 2015, the program tested 733 patients for HCV who reported ≥1 HCV risk factor; 81 (11%) were HCV-infected (i.e., HCV antibody-positive and HCV ribonucleic acid-positive). Fifty-one infected patients (63%) were linked to care. We concluded that essential program resources include reflex HCV ribonucleic acid testing; a dedicated bridge counselor to provide test results, health education, and linkage-to-care assistance; and referral relationships for local HCV management and treatment.

Extragenital Chlamydia and Gonorrhea in Young Black Men Who Have Sex With Men: Missed Treatment Opportunities for HIV-Infected MSM?

This study of young Black MSM (YBMSM) assessed the prevalence of extra-genital chlamydia and gonorrhea among those testing negative for urethral infections, and compared prevalence of both by HIV status.

Hepatitis B Vaccination and Infection Prevalence among Men Who Have Sex with Men Who Travel Internationally.

Among MSM traveling internationally, self-reported HBV vaccination prevalence was 77% and less prevalent among older men and those with HBV infection. HBV infection prevalence was 25% and was associated with older age and HIV infection. Testing for chronic infection, universal vaccination, and treatment for populations with multiple risks is needed.

Scaling-up HIV screening and antiretroviral therapy among men who have sex with men to achieve the 90-90-90 targets in China.

The Joint United Nations Programme on HIV/AIDS has proposed the 90-90-90 targets by 2020. HIV epidemic is spreading rapidly among men who have sex with men (MSM) in China. This study investigates how the scale-up of HIV testing and treatment in achieving the targets and its cost-effectiveness.

Molecular typing and macrolide resistance of syphilis cases in Manitoba, Canada from 2012-2016.

The province of Manitoba, Canada, population of about 1.3 million, has been experiencing increased incidence of syphilis cases since 2015. In this study we examined the detection of T. pallidum DNA in 354 clinical samples from 2012 to 2016; and determined molecular types and mutations conferring resistance to azithromycin in the PCR-positive samples.

Is there a Continuum of Risk for Sexually Transmitted Infections among African American Women?

This study compared sexual risk behaviors and STI prevalence among African American women who have sex with women (WSW), women who have sex with men (WSM) with a single male partner, WSM with ≥4 male partners, and women who have sex with women and men (WSWM) at an STD clinic. The results suggest that, despite differences in prevalence, there was not a clear continuum of STI risk among AA women in the study; all women were at risk.

Conceptualizing Geosexual Archetypes: Mapping the sexual travels and ego-centric sexual networks of gay and bisexual men in Toronto, Canada.

There are complex, synergistic and persistent sexually transmitted infection (STI) epidemics affecting gay, bisexual and other men who have sex with men (gbMSM) in every major urban centre across North America. We explored the spatial architecture of egocentric sexual networks for gbMSM in Toronto, Canada.

Expedited partner therapy: Pharmacist refusal of legal prescriptions.

Expedited partner therapy (EPT) is an effective strategy for partner management of sexually transmitted infections. Some states, including Wisconsin, allow EPT prescriptions to be filled without a patient name. This study determined the refusal rates of nameless EPT prescriptions in Milwaukee pharmacies.

Prevalence of rectal chlamydial and gonococcal infections: a systematic review.

We undertook a systematic review to examine rectal Chlamydia trachomatis (Ct) and Neisseria gonorrhoeae (Ng) infections in women and men who have sex with men (MSM). English-language publications measuring rectal Ct or Ng prevalence using nucleic acid amplification tests were eligible. Searching multiple electronic databases, we identified 115 eligible reports published between January 2000 and November 2016. Overall, the prevalence of rectal Ct (9.0%) was higher than rectal Ng (4.7%). Rectal Ct prevalence was similar in MSM (9%) and women (9.2%), while rectal Ng prevalence was higher in MSM (6.1%) than women (1.7%). Generally, rectal Ct prevalence was similar in STD clinics (9.1%) and non-sexual health clinics (8.6%), whereas rectal Ng prevalence was somewhat lower in STD clinics (4.5%) than non-sexual health clinics (6%). These infections appear to be relatively common across a range of populations and clinical settings, highlighting the need for additional research on these preventable, treatable conditions.

Molecular characterization of markers associated with antimicrobial resistance in Neisseria gonorrhoeae identified from residual clinical samples.

The emergence and spread of antimicrobial-resistant (AMR) Neisseria gonorrhoeae (NG) is a major public health concern. In the era of nucleic acid amplifications tests (NAATs), rapid and accurate molecular approaches are needed to help increase surveillance, guide antimicrobial stewardship, and prevent outbreaks.

Prevalence and Detection of Trichomonas vaginalis in Human Immunodeficiency Virus-Infected Pregnant Women.

Trichomonas vaginalis is a STI associated with increased transmission of HIV and significant adverse birth outcomes; culture and PCR are commonly used in diagnosis.

Ciprofloxacin May be Efficacious in Treating Wild-Type Gyrase A Genotype Neisseria gonorrhoeae Infections.

Screening for Trichomonas vaginalis in a large high-risk population; Prevalence among Males and Females Determined by Nucleic Acid Amplification Testing.

Men and women attending family planning and sexually transmitted disease clinics for STI screening in 2012-2013 were tested for Trichomonas vaginalis (TV) using a sensitive nucleic acid amplification test. TV prevalence in urogenital samples from 77,740 women was 11.3%, 6.1% in 12,604 men, and increased with age in both genders.This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

Chemsex Among Men Who Have Sex With Men: a Sexualized Drug Use Survey Among Clients of the Sexually Transmitted Infection Outpatient Clinic and Users of a Gay Dating App in Amsterdam, the Netherlands.

Chemsex (i.e., drug use during sex) is practiced by some men who have sex with men (MSM) and is associated with high-risk behavior. In a cross-sectional study at the sexually transmitted infection (STI) clinic of Amsterdam, we explored chemsex practices, risk behavior, and STI prevalence.

Variability in Condom Use Trends by Sexual Risk Behaviors: Findings from the 2003-2015 National Youth Risk Behavior Surveys.

To examine variability in condom use trends by sexual risk behavior among US high school students.