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Anti-Ro/SSA and anti-La/SSB autoantibodies in the tear fluid of patients with Sjögren's syndrome.

Abstract To investigate the presence of anti-Ro/SSA and anti-La/SSB antibodies in the tear fluid and serum of patients with Sjögren's syndrome and to evaluate the association of these autoantibodies with the severity of keratoconjunctivitis sicca.
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Authors

Mayor MeshTerms
Keywords
Journal Title the british journal of ophthalmology
Publication Year Start




PMID- 14977774
OWN - NLM
STAT- MEDLINE
DA  - 20040223
DCOM- 20040330
LR  - 20151119
IS  - 0007-1161 (Print)
IS  - 0007-1161 (Linking)
VI  - 88
IP  - 3
DP  - 2004 Mar
TI  - Anti-Ro/SSA and anti-La/SSB autoantibodies in the tear fluid of patients with
      Sjogren's syndrome.
PG  - 384-7
AB  - PURPOSE: To investigate the presence of anti-Ro/SSA and anti-La/SSB antibodies in
      the tear fluid and serum of patients with Sjogren's syndrome and to evaluate the 
      association of these autoantibodies with the severity of keratoconjunctivitis
      sicca. METHODS: Tear fluid and serum were obtained from 28 patients with
      Sjogren's syndrome and 17 age matched normal control subjects. Evaluation of tear
      fluid and sera anti-Ro/SSA and anti-La/SSB levels was done by using a
      quantitative enzyme linked immunosorbent assay kit designed for the quantitative 
      measurement of IgG class autoantibodies directed against highly purified SSA and 
      SSB antigens. Tear function and ocular surface were evaluated by Schirmer I test,
      tear break up time, and rose bengal staining. Dry eye symptom scores were
      recorded. RESULTS: Increased levels of anti-Ro/SSA and anti-La/SSB antibodies
      were detected in sera of 57.1% and 50% of SS patients, respectively. Six patients
      had increased levels of anti-Ro/SSA in the tear fluid, in one case anti-Ro/SSA
      being detected in tear fluid when it was negative in serum. Ten patients had
      positive anti-La/SSB titres in tear fluid and in four of these patients,
      anti-La/SSB titres were not elevated in serum. A positive correlation was
      observed between serum and tear fluid titres of anti-Ro/SSA (r = 0.43, p = 0.02),
      but not of anti-La/SSB. Serum anti-Ro/SSA and anti-La/SSB concentrations
      correlated positively with dry eye symptom scores (r = 0.42, p = 0.02 and r =
      0.48, p = 0.01, respectively) and negatively correlated with Schirmer I test
      scores (r = -0.39, p = 0.04 and r = -0.40, p = 0.03, respectively). Significant
      correlations were found between tear anti-La/SSB concentrations and dry eye
      symptom score (r = 0.56, p = 0.02) and also rose bengal staining scores of the
      ocular surface (r = 0.44, p = 0.02). CONCLUSION: This study shows that
      autoantibodies against Ro/SSA and La/SSB antigens are present in the tear fluid
      of some patients with SS and their presence in serum or tear fluid is associated 
      with the severity of keratoconjunctivitis sicca. Additional measurement of tear
      fluid levels of anti-Ro/SSA and anti-La/SSB may serve as a valuable diagnostic
      indicator of SS.
FAU - Toker, E
AU  - Toker E
AD  - Department of Ophthalmology, Marmara University, School of Medicine, Marmara,
      Turkey. [email protected]
FAU - Yavuz, S
AU  - Yavuz S
FAU - Direskeneli, H
AU  - Direskeneli H
LA  - eng
PT  - Journal Article
PL  - England
TA  - Br J Ophthalmol
JT  - The British journal of ophthalmology
JID - 0421041
RN  - 0 (Antibodies, Antinuclear)
RN  - 0 (Biomarkers)
RN  - 0 (Immunoglobulin G)
RN  - 0 (SS-A antibodies)
RN  - 0 (SS-B antibodies)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antibodies, Antinuclear/*analysis/blood
MH  - Biomarkers/analysis/blood
MH  - Case-Control Studies
MH  - Female
MH  - Humans
MH  - Immunoglobulin G/analysis
MH  - Middle Aged
MH  - Sjogren's Syndrome/blood/*immunology
MH  - Statistics, Nonparametric
MH  - Tears/*immunology
PMC - PMC1772044
OID - NLM: PMC1772044
EDAT- 2004/02/24 05:00
MHDA- 2004/03/31 05:00
CRDT- 2004/02/24 05:00
PST - ppublish
SO  - Br J Ophthalmol. 2004 Mar;88(3):384-7.

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