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Immunological factors and their role in the genesis and development of endometriosis.

Abstract The article presents an overview of immunological factors and their role in the genesis and development of endometriosis, with emphasis on inflammatory cytokines and growth and adhesion factors. Although retrograde menstruation is a common phenomenon among women of reproductive age, not all women with retrograde menstruation suffer the disease. Development of endometriosis seems to be a complex process, facilitated by several factors, including quantity and quality of endometrial cells in peritoneal fluid (PF), increased inflammatory activity in PF, increased endometrial-peritoneal adhesion and angiogenesis, reduced immune surveillance and clearance of endometrial cells, and increased production of autoantibodies against endometrial cells. Potential biomarkers like cytokines and autoantibodies, upregulated during development of endometriosis, seem useful in the development of a non-surgical diagnostic tool. In this review work, the immune role in endometriosis is examined through the role of immunological factors in the genesis and development of the disease. Furthermore, it could be concluded that, although endometriosis can be treated using hormonal suppression, there is a need today for non-hormonal drugs, probably to modulate immune function, in order to confront the disease and alleviate pain or infertility without inhibition of ovulation.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title the journal of obstetrics and gynaecology research
Publication Year Start




PMID- 16594919
OWN - NLM
STAT- MEDLINE
DA  - 20060405
DCOM- 20060824
LR  - 20090908
IS  - 1341-8076 (Print)
IS  - 1341-8076 (Linking)
VI  - 32
IP  - 2
DP  - 2006 Apr
TI  - Immunological factors and their role in the genesis and development of
      endometriosis.
PG  - 162-70
AB  - The article presents an overview of immunological factors and their role in the
      genesis and development of endometriosis, with emphasis on inflammatory cytokines
      and growth and adhesion factors. Although retrograde menstruation is a common
      phenomenon among women of reproductive age, not all women with retrograde
      menstruation suffer the disease. Development of endometriosis seems to be a
      complex process, facilitated by several factors, including quantity and quality
      of endometrial cells in peritoneal fluid (PF), increased inflammatory activity in
      PF, increased endometrial-peritoneal adhesion and angiogenesis, reduced immune
      surveillance and clearance of endometrial cells, and increased production of
      autoantibodies against endometrial cells. Potential biomarkers like cytokines and
      autoantibodies, upregulated during development of endometriosis, seem useful in
      the development of a non-surgical diagnostic tool. In this review work, the
      immune role in endometriosis is examined through the role of immunological
      factors in the genesis and development of the disease. Furthermore, it could be
      concluded that, although endometriosis can be treated using hormonal suppression,
      there is a need today for non-hormonal drugs, probably to modulate immune
      function, in order to confront the disease and alleviate pain or infertility
      without inhibition of ovulation.
FAU - Siristatidis, Charalambos
AU  - Siristatidis C
AD  - Third Department of Obstetrics and Gynecology, University of Athens Medical
      School, Attikon Hospital, Athens, Greece. [email protected]
FAU - Nissotakis, Christos
AU  - Nissotakis C
FAU - Chrelias, Charalambos
AU  - Chrelias C
FAU - Iacovidou, Helen
AU  - Iacovidou H
FAU - Salamalekis, Emmanuel
AU  - Salamalekis E
LA  - eng
PT  - Journal Article
PT  - Retracted Publication
PT  - Review
PL  - Japan
TA  - J Obstet Gynaecol Res
JT  - The journal of obstetrics and gynaecology research
JID - 9612761
RN  - 0 (Autoantibodies)
RN  - 0 (Cytokines)
RN  - 0 (Growth Substances)
RN  - 0 (Interleukins)
RN  - 0 (Leptin)
RN  - 0 (Reactive Oxygen Species)
RN  - 0 (Tumor Necrosis Factors)
RN  - EC 3.4.24.- (Matrix Metalloproteinases)
SB  - IM
RIN - Okai T. J Obstet Gynaecol Res. 2009 Apr;35(2):390. PMID: 19335803
MH  - Ascitic Fluid/chemistry/cytology/immunology
MH  - Autoantibodies
MH  - Cytokines/biosynthesis/immunology
MH  - Endometriosis/etiology/*immunology/pathology
MH  - Female
MH  - Growth Substances/physiology
MH  - Humans
MH  - Interleukins/immunology
MH  - Leptin/physiology
MH  - Macrophages/metabolism
MH  - Matrix Metalloproteinases/physiology
MH  - Reactive Oxygen Species
MH  - Tumor Necrosis Factors/immunology
RF  - 58
EDAT- 2006/04/06 09:00
MHDA- 2006/08/25 09:00
CRDT- 2006/04/06 09:00
AID - JOG [pii]
AID - 10.1111/j.1447-0756.2006.00373.x [doi]
PST - ppublish
SO  - J Obstet Gynaecol Res. 2006 Apr;32(2):162-70.

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