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Dynamic expression of Runx1 in skin affects hair structure.

Abstract The three mammalian Runx transcription factors, some of which are known to be involved in human genetic diseases and cancer, are pivotal players in embryo development and function as key regulators of cell fate determination and organogenesis. Here, we report the expression of Runx1 during the development of hair and other skin appendages in the mouse and describe the effect of Runx1 on the structural hair output. In hair follicles, where the three Runx proteins are expressed, Runx1 expression is most prominent in both mesenchymal and epithelial compartments. The epithelial expression includes the hair keratin forming layers of the hair shaft and the bulge, where interestingly, Runx1 is co-expressed with keratin 15, a putative hair follicle stem cell marker. In the hair mesenchyme, during early stages of hair morphogenesis, Runx1 is expressed in a discrete dermal sub-epithelial layer, while at later stages it is found in a hair cycle dependent pattern in the dermal papilla. To elucidate the function of Runx1 in the hair follicle we have generated a Runx1 epidermal conditional knockout and found that the mutant mice display a remarkable structural deformation of the zigzag hair type. The data delineate Runx1 as a novel specific marker of several hair follicle cell types and sheds light on its role in hair morphogenesis and differentiation.
PMID
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Authors

Mayor MeshTerms

Gene Expression Regulation, Developmental

Keywords
Journal Title mechanisms of development
Publication Year Start




PMID- 17011173
OWN - NLM
STAT- MEDLINE
DA  - 20061114
DCOM- 20070612
LR  - 20061114
IS  - 0925-4773 (Print)
IS  - 0925-4773 (Linking)
VI  - 123
IP  - 11
DP  - 2006 Nov
TI  - Dynamic expression of Runx1 in skin affects hair structure.
PG  - 842-50
AB  - The three mammalian Runx transcription factors, some of which are known to be
      involved in human genetic diseases and cancer, are pivotal players in embryo
      development and function as key regulators of cell fate determination and
      organogenesis. Here, we report the expression of Runx1 during the development of 
      hair and other skin appendages in the mouse and describe the effect of Runx1 on
      the structural hair output. In hair follicles, where the three Runx proteins are 
      expressed, Runx1 expression is most prominent in both mesenchymal and epithelial 
      compartments. The epithelial expression includes the hair keratin forming layers 
      of the hair shaft and the bulge, where interestingly, Runx1 is co-expressed with 
      keratin 15, a putative hair follicle stem cell marker. In the hair mesenchyme,
      during early stages of hair morphogenesis, Runx1 is expressed in a discrete
      dermal sub-epithelial layer, while at later stages it is found in a hair cycle
      dependent pattern in the dermal papilla. To elucidate the function of Runx1 in
      the hair follicle we have generated a Runx1 epidermal conditional knockout and
      found that the mutant mice display a remarkable structural deformation of the
      zigzag hair type. The data delineate Runx1 as a novel specific marker of several 
      hair follicle cell types and sheds light on its role in hair morphogenesis and
      differentiation.
FAU - Raveh, Eli
AU  - Raveh E
AD  - Department of Cell and Animal Biology, Silberman Life Sciences Institute, Edmond 
      Safra Campus at Givat-Ram, The Hebrew University, Jerusalem 91904, Israel.
FAU - Cohen, Shulamit
AU  - Cohen S
FAU - Levanon, Ditsa
AU  - Levanon D
FAU - Negreanu, Varda
AU  - Negreanu V
FAU - Groner, Yoram
AU  - Groner Y
FAU - Gat, Uri
AU  - Gat U
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20060809
PL  - Ireland
TA  - Mech Dev
JT  - Mechanisms of development
JID - 9101218
RN  - 0 (Core Binding Factor Alpha 2 Subunit)
RN  - 0 (Runx1 protein, mouse)
SB  - IM
MH  - Animals
MH  - Cell Cycle
MH  - Cell Differentiation
MH  - Core Binding Factor Alpha 2 Subunit/deficiency/genetics/*metabolism
MH  - *Gene Expression Regulation, Developmental
MH  - Hair/cytology/embryology/*growth & development/*metabolism
MH  - Mice
MH  - Mice, Knockout
MH  - Skin/cytology/embryology/growth & development/*metabolism
EDAT- 2006/10/03 09:00
MHDA- 2007/06/15 09:00
CRDT- 2006/10/03 09:00
PHST- 2006/07/11 [received]
PHST- 2006/08/01 [revised]
PHST- 2006/08/03 [accepted]
AID - S0925-4773(06)00120-1 [pii]
AID - 10.1016/j.mod.2006.08.002 [doi]
PST - ppublish
SO  - Mech Dev. 2006 Nov;123(11):842-50. Epub 2006 Aug 9.