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Diagnostic value of interferon-gamma in tuberculous pleurisy: a metaanalysis.

Abstract Conventional tests are not always helpful in making a diagnosis of tuberculous pleurisy. Many studies have investigated the usefulness of interferon (IFN)-gamma measurements in pleural fluid for the early diagnosis of tuberculous pleurisy. We conducted a metaanalysis to determine the accuracy of IFN-gamma measurements in the diagnosis of tuberculous pleurisy.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title chest
Publication Year Start




PMID- 17426220
OWN - NLM
STAT- MEDLINE
DCOM- 20070508
LR  - 20151119
IS  - 0012-3692 (Print)
IS  - 0012-3692 (Linking)
VI  - 131
IP  - 4
DP  - 2007 Apr
TI  - Diagnostic value of interferon-gamma in tuberculous pleurisy: a metaanalysis.
PG  - 1133-41
AB  - BACKGROUND: Conventional tests are not always helpful in making a diagnosis of
      tuberculous pleurisy. Many studies have investigated the usefulness of interferon
      (IFN)-gamma measurements in pleural fluid for the early diagnosis of tuberculous 
      pleurisy. We conducted a metaanalysis to determine the accuracy of IFN-gamma
      measurements in the diagnosis of tuberculous pleurisy. METHODS: After a
      systematic review of English-language studies, sensitivity, specificity, and
      other measures of accuracy of IFN-gamma concentrations in the diagnosis of
      pleural effusion were pooled using random-effects models. Summary receiver
      operating characteristic curves were used to summarize overall test performance. 
      RESULTS: Twenty-two studies met our inclusion criteria. The summary estimates for
      IFN-gamma in the diagnosis of tuberculous pleurisy in the studies included were
      as follows: sensitivity, 0.89 (95% confidence interval [CI], 0.87 to 0.91);
      specificity, 0.97 (95% CI, 0.96 to 0.98); positive likelihood ratio, 23.45 (95%
      CI, 17.31 to 31.78); negative likelihood ratio, 0.11 (95% CI, 0.07 to 0.16); and 
      diagnostic odds ratio, 272.7 (95% CI, 147.5 to 504.2). CONCLUSIONS: IFN-gamma
      determination is a sensitive and specific test for the diagnosis of tuberculous
      pleurisy. The measurement of IFN-gamma levels in pleural effusions is thus likely
      to be a useful tool for diagnosing tuberculous pleurisy. The results of IFN-gamma
      assays should be interpreted in parallel with clinical findings and the results
      of conventional tests.
FAU - Jiang, Jing
AU  - Jiang J
AD  - Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical
      University, Nanning 530021, Guangxi, People's Republic of China.
FAU - Shi, Huan-Zhong
AU  - Shi HZ
FAU - Liang, Qiu-Li
AU  - Liang QL
FAU - Qin, Shou-Ming
AU  - Qin SM
FAU - Qin, Xue-Jun
AU  - Qin XJ
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
PL  - United States
TA  - Chest
JT  - Chest
JID - 0231335
RN  - 0 (Biomarkers)
RN  - 82115-62-6 (Interferon-gamma)
SB  - AIM
SB  - IM
MH  - Biomarkers/metabolism
MH  - Confidence Intervals
MH  - Diagnosis, Differential
MH  - Humans
MH  - Interferon-gamma/*metabolism
MH  - Pleural Effusion/diagnosis/etiology/*metabolism
MH  - Reproducibility of Results
MH  - Sensitivity and Specificity
MH  - Tuberculosis, Pleural/complications/*diagnosis/metabolism
RF  - 60
EDAT- 2007/04/12 09:00
MHDA- 2007/05/09 09:00
CRDT- 2007/04/12 09:00
PHST- 2007/04/12 09:00 [pubmed]
PHST- 2007/05/09 09:00 [medline]
PHST- 2007/04/12 09:00 [entrez]
AID - S0012-3692(15)49042-7 [pii]
AID - 10.1378/chest.06-2273 [doi]
PST - ppublish
SO  - Chest. 2007 Apr;131(4):1133-41. doi: 10.1378/chest.06-2273.