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Unexplained infertility: does it really exist? Does it matter?

Abstract Unexplained infertility (UI) refers to a diagnosis made in couples in whom standard investigations including semen analysis, tests of ovulation and tubal patency are normal. It has been suggested that the term UI is unsustainable, as conditions such as endometriosis, tubal infertility, premature ovarian ageing and immunological infertility tend to be misdiagnosed as UI. In this debate, we present the view that, although scientifically unsatisfying, the diagnosis of UI is sustainable from a clinical and practical perspective. Given our present treatment options, further investigations leading to a more 'accurate' diagnosis is unlikely to change our management in these cases. Scientific curiosity must take second place to a more pragmatic approach, which takes into account the clinical and financial costs of making a more 'accurate' diagnosis.
PMID
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Unexplained infertility: does it really exist?

Authors

Mayor MeshTerms
Keywords
Journal Title human reproduction (oxford, england)
Publication Year Start


 


PMID- 17562677
OWN - NLM
STAT- MEDLINE
DA  - 20070727
DCOM- 20071012
LR  - 20080606
IS  - 0268-1161 (Print)
IS  - 0268-1161 (Linking)
VI  - 22
IP  - 8
DP  - 2007 Aug
TI  - Unexplained infertility: does it really exist? Does it matter?
PG  - 2084-7
AB  - Unexplained infertility (UI) refers to a diagnosis made in couples in whom
      standard investigations including semen analysis, tests of ovulation and tubal
      patency are normal. It has been suggested that the term UI is unsustainable, as
      conditions such as endometriosis, tubal infertility, premature ovarian ageing and
      immunological infertility tend to be misdiagnosed as UI. In this debate, we
      present the view that, although scientifically unsatisfying, the diagnosis of UI 
      is sustainable from a clinical and practical perspective. Given our present
      treatment options, further investigations leading to a more 'accurate' diagnosis 
      is unlikely to change our management in these cases. Scientific curiosity must
      take second place to a more pragmatic approach, which takes into account the
      clinical and financial costs of making a more 'accurate' diagnosis.
FAU - Siristatidis, Charalambos
AU  - Siristatidis C
AD  - Assisted Reproduction Unit, Department of Obstetrics and Gynaecology, Aberdeen
      Maternity Hospital, Foresterhill, Aberdeen, UK. [email protected]
FAU - Bhattacharya, Siladitya
AU  - Bhattacharya S
LA  - eng
PT  - Journal Article
DEP - 20070611
PL  - England
TA  - Hum Reprod
JT  - Human reproduction (Oxford, England)
JID - 8701199
SB  - IM
CIN - Hum Reprod. 2008 May;23(5):1237-8. PMID: 18353904
MH  - Endometriosis/complications
MH  - Fallopian Tube Diseases/complications
MH  - Female
MH  - Humans
MH  - Infertility/diagnosis/*etiology/immunology
MH  - Male
MH  - Maternal Age
MH  - Pregnancy
EDAT- 2007/06/15 09:00
MHDA- 2007/10/13 09:00
CRDT- 2007/06/15 09:00
PHST- 2007/06/11 [aheadofprint]
AID - dem117 [pii]
AID - 10.1093/humrep/dem117 [doi]
PST - ppublish
SO  - Hum Reprod. 2007 Aug;22(8):2084-7. Epub 2007 Jun 11.

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