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Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a meta-analysis.

Abstract Conventional tests are not always helpful in making a diagnosis of tuberculous pleurisy. Many studies have investigated the usefulness of adenosine deaminase (ADA) in pleural fluid for the early diagnosis of tuberculous pleurisy. We conducted a meta-analysis to determine the accuracy of ADA measurements in the diagnosis of tuberculous pleurisy.
PMID
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Authors

Mayor MeshTerms

Mycobacterium tuberculosis

Keywords
Journal Title respiratory medicine
Publication Year Start




PMID- 18222681
OWN - NLM
STAT- MEDLINE
DCOM- 20080811
LR  - 20151119
IS  - 0954-6111 (Print)
IS  - 0954-6111 (Linking)
VI  - 102
IP  - 5
DP  - 2008 May
TI  - Diagnostic accuracy of adenosine deaminase in tuberculous pleurisy: a
      meta-analysis.
PG  - 744-54
LID - 10.1016/j.rmed.2007.12.007 [doi]
AB  - BACKGROUND: Conventional tests are not always helpful in making a diagnosis of
      tuberculous pleurisy. Many studies have investigated the usefulness of adenosine 
      deaminase (ADA) in pleural fluid for the early diagnosis of tuberculous pleurisy.
      We conducted a meta-analysis to determine the accuracy of ADA measurements in the
      diagnosis of tuberculous pleurisy. METHODS: After a systematic review of English 
      language studies, sensitivity, specificity, and other measures of accuracy of ADA
      concentration in the diagnosis of pleural effusion were pooled using random
      effects models. Summary receiver operating characteristic curves were used to
      summarize overall test performance. RESULTS: Sixty-three studies met our
      inclusion criteria. The summary estimates for ADA in the diagnosis of tuberculous
      pleurisy in the studies included were sensitivity 0.92 (95% confidence interval
      0.90-0.93), specificity 0.90 (95% confidence interval 0.89-0.91), positive
      likelihood ratio 9.03 (95% confidence interval 7.19-11.35), negative likelihood
      ratio 0.10 (95% confidence interval 0.07-0.14), and diagnostic odds ratio 110.08 
      (95% confidence interval 69.96-173.20). CONCLUSIONS: ADA determination is a
      relative sensitive and specific test for the diagnosis of tuberculous pleurisy.
      Measurement of ADA in pleural effusion is thus likely to be a useful diagnostic
      tool for tuberculous pleurisy. The results of ADA assays should be interpreted in
      parallel with clinical findings and the results of conventional tests.
FAU - Liang, Qiu-Li
AU  - Liang QL
AD  - Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical
      University, Nanning, 530021 Guangxi, People's Republic of China.
FAU - Shi, Huan-Zhong
AU  - Shi HZ
FAU - Wang, Ke
AU  - Wang K
FAU - Qin, Shou-Ming
AU  - Qin SM
FAU - Qin, Xue-Jun
AU  - Qin XJ
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PT  - Research Support, Non-U.S. Gov't
PT  - Review
DEP - 20080128
PL  - England
TA  - Respir Med
JT  - Respiratory medicine
JID - 8908438
RN  - 0 (Biomarkers)
RN  - EC 3.5.4.4 (Adenosine Deaminase)
SB  - IM
MH  - Adenosine Deaminase/*analysis
MH  - Biomarkers/analysis
MH  - Clinical Enzyme Tests
MH  - Humans
MH  - *Mycobacterium tuberculosis
MH  - Odds Ratio
MH  - Pleural Effusion/*enzymology
MH  - ROC Curve
MH  - Sensitivity and Specificity
MH  - Tuberculosis, Pleural/*diagnosis
RF  - 118
EDAT- 2008/01/29 09:00
MHDA- 2008/08/12 09:00
CRDT- 2008/01/29 09:00
PHST- 2007/03/20 00:00 [received]
PHST- 2007/11/16 00:00 [revised]
PHST- 2007/12/13 00:00 [accepted]
PHST- 2008/01/29 09:00 [pubmed]
PHST- 2008/08/12 09:00 [medline]
PHST- 2008/01/29 09:00 [entrez]
AID - S0954-6111(07)00506-9 [pii]
AID - 10.1016/j.rmed.2007.12.007 [doi]
PST - ppublish
SO  - Respir Med. 2008 May;102(5):744-54. doi: 10.1016/j.rmed.2007.12.007. Epub 2008
      Jan 28.