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PMID- 19362778
OWN - NLM
STAT- MEDLINE
DCOM- 20090921
LR  - 20151119
IS  - 1879-355X (Electronic)
IS  - 0360-3016 (Linking)
VI  - 75
IP  - 2
DP  - 2009 Oct 1
TI  - C-reactive protein levels and radiation-induced mucositis in patients with
      head-and-neck cancer.
PG  - 393-8
LID - 10.1016/j.ijrobp.2008.11.012 [doi]
AB  - PURPOSE: To evaluate the relationship between C-reactive protein (CRP) levels or 
      the erythrocyte sedimentation rate (ESR) and the grade of acute radiation-induced
      mucositis in patients with head-and-neck cancer. METHODS AND MATERIALS: This
      study was performed in 40 patients who received intensity-modulated radiation
      therapy as a radical treatment of primary laryngo-pharyngeal cancer. Serum CRP
      level and ESR were initially checked on the day of radiotherapy simulation and
      were measured every week during the irradiation schedule and two times biweekly
      after radiotherapy. Mucosal reactions were evaluated by radiation oncologists on 
      days of blood sampling. RESULTS: The distribution of the most severe mucositis
      was Grade I mucositis in 10% of the patients, Grade II in 60% of the patients and
      Grade III in 30% of the patients. Statistical analysis indicated a significant
      rise in the CRP level (p < 0.001) according to radiation fraction number and
      grade of mucositis. A change of the mean CRP level was correlated with
      progression of mean grade of mucositis according to fraction number. The ESR did 
      not show any statistically significant relationship with radiotherapy fraction
      number and grade of acute mucositis. CONCLUSIONS: There was a significant
      correlation between the presence of acute mucositis and CRP level in this study. 
      The CRP level could be conveniently determined along with evaluation of mucosal
      reactions during or after radiotherapy to provide further information on
      radiation-induced mucositis.
FAU - Ki, Yongkan
AU  - Ki Y
AD  - Department of Radiation Oncology, Pusan National University School of Medicine,
      Busan, Korea.
FAU - Kim, Wontaek
AU  - Kim W
FAU - Nam, Jiho
AU  - Nam J
FAU - Kim, Donghyun
AU  - Kim D
FAU - Park, Dahl
AU  - Park D
FAU - Kim, Dongwon
AU  - Kim D
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20090411
PL  - United States
TA  - Int J Radiat Oncol Biol Phys
JT  - International journal of radiation oncology, biology, physics
JID - 7603616
RN  - 0 (Biomarkers)
RN  - 9007-41-4 (C-Reactive Protein)
SB  - IM
MH  - Acute Disease
MH  - Aged
MH  - Biomarkers/blood
MH  - Blood Sedimentation
MH  - C-Reactive Protein/*analysis
MH  - Carcinoma, Squamous Cell/radiotherapy
MH  - Female
MH  - Head and Neck Neoplasms/radiotherapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Mucosa/radiation effects
MH  - Mucositis/*blood/pathology
MH  - Radiation Injuries/*blood/pathology
MH  - Radiotherapy, Intensity-Modulated/*adverse effects/methods
EDAT- 2009/04/14 09:00
MHDA- 2009/09/22 06:00
CRDT- 2009/04/14 09:00
PHST- 2008/08/29 00:00 [received]
PHST- 2008/10/27 00:00 [revised]
PHST- 2008/11/05 00:00 [accepted]
PHST- 2009/04/14 09:00 [entrez]
PHST- 2009/04/14 09:00 [pubmed]
PHST- 2009/09/22 06:00 [medline]
AID - S0360-3016(08)03724-3 [pii]
AID - 10.1016/j.ijrobp.2008.11.012 [doi]
PST - ppublish
SO  - Int J Radiat Oncol Biol Phys. 2009 Oct 1;75(2):393-8. doi:
      10.1016/j.ijrobp.2008.11.012. Epub 2009 Apr 11.