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PMID- 19841102
OWN - NLM
STAT- MEDLINE
DCOM- 20100226
LR  - 20131121
IS  - 1465-3621 (Electronic)
IS  - 0368-2811 (Linking)
VI  - 40
IP  - 2
DP  - 2010 Feb
TI  - A two-step intensity-modulated radiation therapy method for nasopharyngeal
      cancer: the Kinki University experience.
PG  - 130-8
LID - 10.1093/jjco/hyp136 [doi]
AB  - OBJECTIVE: The aim of this study was to analyze the clinical results of our
      adaptive radiation therapy scheme of a two-step intensity-modulated radiotherapy 
      (IMRT) method for nasopharyngeal cancer (NPC) at Kinki University Hospital.
      METHODS: Between 2000 and 2007, 35 patients with Stage I-IVB NPC treated by IMRT 
      were included. For all patients, treatment-planning computed tomography was done 
      twice before and during IMRT to a total dose of 60-70 Gy/28-35 fractions (median 
      68 Gy). Chemotherapy (cisplatin 80 mg/m(2)/3 weeks x 1-3 courses) was given
      concurrently with IMRT for 31 patients. RESULTS: The 3- and 5-year overall
      survival rates for the 31 patients treated with concurrent chemotherapy were 88% 
      and 83%, respectively. The 3- and 5-year loco-regional control rates for the 31
      patients were 93% and 87%, respectively. Planning target volume delineation for
      the primary site or involved nodes was insufficient for three early cases,
      resulting in marginal recurrence in the three patients (9%). Except for one
      patient with early death, xerostomia scores at 1-2 years were: Grade 0, 11; Grade
      1, 17; Grade 2, 5; Grade 3, 1. CONCLUSIONS: Excellent overall survival and
      loco-regional control rates were obtained by a two-step IMRT method with
      concurrent chemotherapy for NPC, although marginal recurrence was noted in some
      early cases.
FAU - Nishimura, Yasumasa
AU  - Nishimura Y
AD  - Department of Radiation Oncology, Kinki University School of Medicine, Osaka,
      Japan. [email protected]
FAU - Shibata, Toru
AU  - Shibata T
FAU - Nakamatsu, Kiyoshi
AU  - Nakamatsu K
FAU - Kanamori, Shuichi
AU  - Kanamori S
FAU - Koike, Ryuta
AU  - Koike R
FAU - Okubo, Mitsuru
AU  - Okubo M
FAU - Nishikawa, Tatsuyuki
AU  - Nishikawa T
FAU - Tachibana, Izumi
AU  - Tachibana I
FAU - Tamura, Masaya
AU  - Tamura M
FAU - Okumura, Masahiko
AU  - Okumura M
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20091019
PL  - England
TA  - Jpn J Clin Oncol
JT  - Japanese journal of clinical oncology
JID - 0313225
RN  - 0 (Antineoplastic Agents)
RN  - Q20Q21Q62J (Cisplatin)
SB  - IM
MH  - Adolescent
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Antineoplastic Agents/therapeutic use
MH  - Cisplatin/therapeutic use
MH  - Combined Modality Therapy
MH  - Female
MH  - Humans
MH  - Japan
MH  - Male
MH  - Middle Aged
MH  - Nasopharyngeal Neoplasms/drug therapy/mortality/*radiotherapy
MH  - Neoplasm Staging
MH  - Radiotherapy Dosage
MH  - *Radiotherapy, Intensity-Modulated
MH  - Retrospective Studies
MH  - Young Adult
EDAT- 2009/10/21 06:00
MHDA- 2010/02/27 06:00
CRDT- 2009/10/21 06:00
PHST- 2009/10/21 06:00 [entrez]
PHST- 2009/10/21 06:00 [pubmed]
PHST- 2010/02/27 06:00 [medline]
AID - hyp136 [pii]
AID - 10.1093/jjco/hyp136 [doi]
PST - ppublish
SO  - Jpn J Clin Oncol. 2010 Feb;40(2):130-8. doi: 10.1093/jjco/hyp136. Epub 2009 Oct
      19.