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Transcatheter aortic valve implantation in patients with and without concomitant coronary artery disease: comparison of characteristics and early outcome in the German multicenter TAVI registry.

Abstract To examine the prevalence and impact of concomitant coronary artery disease (CAD) on short-term outcome after transcatheter aortic valve implantation (TAVI).
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title clinical research in cardiology : official journal of the german cardiac society
Publication Year Start
%A Abdel-Wahab, Mohamed; Zahn, Ralf; Horack, Martin; Gerckens, Ulrich; Schuler, Gerhard; Sievert, Horst; Naber, Christoph; Voehringer, Matthias; Sch?fer, Ulrich; Senges, Jochen; Richardt, Gert
%T Transcatheter aortic valve implantation in patients with and without concomitant coronary artery disease: comparison of characteristics and early outcome in the German multicenter TAVI registry.
%J Clinical research in cardiology : official journal of the German Cardiac Society, vol. 101, no. 12, pp. 973-981
%D 12/2012
%V 101
%N 12
%M eng
%B To examine the prevalence and impact of concomitant coronary artery disease (CAD) on short-term outcome after transcatheter aortic valve implantation (TAVI).
%K Age Factors, Aged, Aged, 80 and over, Aortic Valve Stenosis, Cardiac Catheterization, Coronary Artery Disease, Female, Germany, Heart Valve Prosthesis Implantation, Hospital Mortality, Humans, Male, Prevalence, Prospective Studies, Quality of Life, Registries, Risk Factors, Sex Factors, Time Factors, Treatment Outcome
%P 973
%L 981
%Y 10.1007/s00392-012-0486-5
%W PHY
%G AUTHOR
%R 2012......101..973A

@Article{Abdel-Wahab2012,
author="Abdel-Wahab, Mohamed
and Zahn, Ralf
and Horack, Martin
and Gerckens, Ulrich
and Schuler, Gerhard
and Sievert, Horst
and Naber, Christoph
and Voehringer, Matthias
and Sch{\"a}fer, Ulrich
and Senges, Jochen
and Richardt, Gert",
title="Transcatheter aortic valve implantation in patients with and without concomitant coronary artery disease: comparison of characteristics and early outcome in the German multicenter TAVI registry.",
journal="Clinical research in cardiology : official journal of the German Cardiac Society",
year="2012",
month="Dec",
day="07",
volume="101",
number="12",
pages="973--981",
keywords="Age Factors",
keywords="Aged",
keywords="Aged, 80 and over",
keywords="Aortic Valve Stenosis",
keywords="Cardiac Catheterization",
keywords="Coronary Artery Disease",
keywords="Female",
keywords="Germany",
keywords="Heart Valve Prosthesis Implantation",
keywords="Hospital Mortality",
keywords="Humans",
keywords="Male",
keywords="Prevalence",
keywords="Prospective Studies",
keywords="Quality of Life",
keywords="Registries",
keywords="Risk Factors",
keywords="Sex Factors",
keywords="Time Factors",
keywords="Treatment Outcome",
abstract="To examine the prevalence and impact of concomitant coronary artery disease (CAD) on short-term outcome after transcatheter aortic valve implantation (TAVI).",
issn="1861-0692",
doi="10.1007/s00392-012-0486-5",
url="http://www.ncbi.nlm.nih.gov/pubmed/22772776",
language="eng"
}

%0 Journal Article
%T Transcatheter aortic valve implantation in patients with and without concomitant coronary artery disease: comparison of characteristics and early outcome in the German multicenter TAVI registry.
%A Abdel-Wahab, Mohamed
%A Zahn, Ralf
%A Horack, Martin
%A Gerckens, Ulrich
%A Schuler, Gerhard
%A Sievert, Horst
%A Naber, Christoph
%A Voehringer, Matthias
%A Sch?fer, Ulrich
%A Senges, Jochen
%A Richardt, Gert
%J Clinical research in cardiology : official journal of the German Cardiac Society
%D 2012
%8 Dec 07
%V 101
%N 12
%@ 1861-0692
%G eng
%F Abdel-Wahab2012
%X To examine the prevalence and impact of concomitant coronary artery disease (CAD) on short-term outcome after transcatheter aortic valve implantation (TAVI).
%K Age Factors
%K Aged
%K Aged, 80 and over
%K Aortic Valve Stenosis
%K Cardiac Catheterization
%K Coronary Artery Disease
%K Female
%K Germany
%K Heart Valve Prosthesis Implantation
%K Hospital Mortality
%K Humans
%K Male
%K Prevalence
%K Prospective Studies
%K Quality of Life
%K Registries
%K Risk Factors
%K Sex Factors
%K Time Factors
%K Treatment Outcome
%U http://dx.doi.org/10.1007/s00392-012-0486-5
%U http://www.ncbi.nlm.nih.gov/pubmed/22772776
%P 973-981

PT Journal
AU Abdel-Wahab, M
   Zahn, R
   Horack, M
   Gerckens, U
   Schuler, G
   Sievert, H
   Naber, C
   Voehringer, M
   Sch?fer, U
   Senges, J
   Richardt, G
TI Transcatheter aortic valve implantation in patients with and without concomitant coronary artery disease: comparison of characteristics and early outcome in the German multicenter TAVI registry.
SO Clinical research in cardiology : official journal of the German Cardiac Society
JI Clin Res Cardiol
PD Dec
PY 2012
BP 973
EP 981
VL 101
IS 12
DI 10.1007/s00392-012-0486-5
LA eng
DE Age Factors; Aged; Aged, 80 and over; Aortic Valve Stenosis; Cardiac Catheterization; Coronary Artery Disease; Female; Germany; Heart Valve Prosthesis Implantation; Hospital Mortality; Humans; Male; Prevalence; Prospective Studies; Quality of Life; Registries; Risk Factors; Sex Factors; Time Factors; Treatment Outcome
AB To examine the prevalence and impact of concomitant coronary artery disease (CAD) on short-term outcome after transcatheter aortic valve implantation (TAVI).
ER

PMID- 22772776
OWN - NLM
STAT- MEDLINE
DA  - 20121119
DCOM- 20130501
IS  - 1861-0692 (Electronic)
IS  - 1861-0684 (Linking)
VI  - 101
IP  - 12
DP  - 2012 Dec
TI  - Transcatheter aortic valve implantation in patients with and without concomitant 
      coronary artery disease: comparison of characteristics and early outcome in the
      German multicenter TAVI registry.
PG  - 973-81
LID - 10.1007/s00392-012-0486-5 [doi]
AB  - OBJECTIVE: To examine the prevalence and impact of concomitant coronary artery
      disease (CAD) on short-term outcome after transcatheter aortic valve implantation
      (TAVI). BACKGROUND: The prevalence of CAD in patients undergoing surgical aortic 
      valve replacement is estimated at 30-50 % and its presence increases procedural
      risk. The prevalence and impact of CAD on outcome after TAVI are not well
      defined. METHODS: We analyzed 1,382 patients enrolled in the German TAVI
      registry; the majority (81 %) received the Medtronic CoreValve. The presence of
      coronary lesions with >/=50 % stenosis on pre-TAVI angiography defined the
      existence of concomitant CAD. RESULTS: 859 patients (62.2 %) had concomitant CAD,
      of which 534 (62.3 %) had multi-vessel and 83 (9.7 %) left main disease. Patients
      with CAD were younger (81.5 +/- 6.1 vs. 82.1 +/- 6.3 years, p < 0.05), more
      commonly males (49.4 vs. 30.0 %, p < 0.0001) and diabetics (36.9 vs. 31.2 %, p < 
      0.05), and had a worse Canadian Cardiovascular Society angina class at baseline
      compared to patients with no CAD. During TAVI patients with CAD more often
      required additional coronary intervention and had longer procedures, but
      procedural success rates were similar (97.1 vs. 97.7 %). Crude in-hospital
      mortality was higher in patients with CAD (10.0 vs. 5.5 %, OR 1.90, 95 % CI
      1.23-2.93), but this was not significant after adjustment for confounders
      (adjusted OR 1.41, 95 % CI 0.85-2.33). Both groups had significant improvement in
      30-day symptoms and quality of life. CONCLUSION: The prevalence of CAD in
      contemporary TAVI patients is high. Its presence characterizes a high-risk
      population and is associated with increased crude short-term mortality, largely
      explained by co-morbidities, but does not limit functional improvement after
      TAVI.
FAU - Abdel-Wahab, Mohamed
AU  - Abdel-Wahab M
AD  - Heart Center, Segeberger Kliniken GmbH, Academic Teaching Hospital of the
      Universities of Kiel and Hamburg, Am Kurpark 1, 23795, Bad Segeberg, Germany.
      [email protected]
FAU - Zahn, Ralf
AU  - Zahn R
FAU - Horack, Martin
AU  - Horack M
FAU - Gerckens, Ulrich
AU  - Gerckens U
FAU - Schuler, Gerhard
AU  - Schuler G
FAU - Sievert, Horst
AU  - Sievert H
FAU - Naber, Christoph
AU  - Naber C
FAU - Voehringer, Matthias
AU  - Voehringer M
FAU - Schafer, Ulrich
AU  - Schafer U
FAU - Senges, Jochen
AU  - Senges J
FAU - Richardt, Gert
AU  - Richardt G
LA  - eng
PT  - Journal Article
PT  - Multicenter Study
DEP - 20120707
PL  - Germany
TA  - Clin Res Cardiol
JT  - Clinical research in cardiology : official journal of the German Cardiac Society
JID - 101264123
SB  - IM
MH  - Age Factors
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/*surgery
MH  - Cardiac Catheterization/*methods
MH  - Coronary Artery Disease/complications/*physiopathology
MH  - Female
MH  - Germany
MH  - Heart Valve Prosthesis Implantation/*methods
MH  - Hospital Mortality
MH  - Humans
MH  - Male
MH  - Prevalence
MH  - Prospective Studies
MH  - Quality of Life
MH  - Registries
MH  - Risk Factors
MH  - Sex Factors
MH  - Time Factors
MH  - Treatment Outcome
EDAT- 2012/07/10 06:00
MHDA- 2013/05/02 06:00
CRDT- 2012/07/10 06:00
PHST- 2012/03/03 [received]
PHST- 2012/06/08 [accepted]
PHST- 2012/07/07 [aheadofprint]
AID - 10.1007/s00392-012-0486-5 [doi]
PST - ppublish
SO  - Clin Res Cardiol. 2012 Dec;101(12):973-81. doi: 10.1007/s00392-012-0486-5. Epub
      2012 Jul 7.
TY  - JOUR
AU  - Abdel-Wahab, Mohamed
AU  - Zahn, Ralf
AU  - Horack, Martin
AU  - Gerckens, Ulrich
AU  - Schuler, Gerhard
AU  - Sievert, Horst
AU  - Naber, Christoph
AU  - Voehringer, Matthias
AU  - Sch?fer, Ulrich
AU  - Senges, Jochen
AU  - Richardt, Gert
PY  - 2012/Dec/07
TI  - Transcatheter aortic valve implantation in patients with and without concomitant coronary artery disease: comparison of characteristics and early outcome in the German multicenter TAVI registry.
T2  - Clin Res Cardiol
JO  - Clinical research in cardiology : official journal of the German Cardiac Society
SP  - 973
EP  - 981
VL  - 101
IS  - 12
KW  - Age Factors
KW  - Aged
KW  - Aged, 80 and over
KW  - Aortic Valve Stenosis
KW  - Cardiac Catheterization
KW  - Coronary Artery Disease
KW  - Female
KW  - Germany
KW  - Heart Valve Prosthesis Implantation
KW  - Hospital Mortality
KW  - Humans
KW  - Male
KW  - Prevalence
KW  - Prospective Studies
KW  - Quality of Life
KW  - Registries
KW  - Risk Factors
KW  - Sex Factors
KW  - Time Factors
KW  - Treatment Outcome
N2  - To examine the prevalence and impact of concomitant coronary artery disease (CAD) on short-term outcome after transcatheter aortic valve implantation (TAVI).
SN  - 1861-0692
UR  - http://dx.doi.org/10.1007/s00392-012-0486-5
UR  - http://www.ncbi.nlm.nih.gov/pubmed/22772776
ID  - Abdel-Wahab2012
ER  - 
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