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Genetic advances of type 2 diabetes in Chinese populations.

Abstract In recent decades, the prevalence of type 2 diabetes in China has increased significantly, underscoring the importance of investigating the etiological mechanisms, including genetic determinants, of the disease in Chinese populations. Numerous loci conferring susceptibility to type 2 diabetes (T2D) have been identified worldwide, with most having been identified in European populations. In terms of ethnic heterogeneity in pathogenesis as well as disease predisposition, it is imperative to explore the specific genetic architecture of T2D in Han Chinese. Replication studies of European-derived susceptibility loci have been performed, validating 11 of 32 loci in Chinese populations. Genetic investigations into heritable traits related to glucose metabolism are expected to provide new insights into the pathogenesis of T2D, and such studies have already inferred some new susceptibility loci. Other than replication studies of European-derived loci, efforts have been made to identify specific susceptibility loci in Chinese populations using methods such as genome-wide association studies. These efforts have identified additional new loci for the disease. Genetic studies can facilitate the prediction of risk for T2D and also promote individualized anti-diabetic treatment. Despite many advances in the field of risk prediction and pharmacogenetics, the pace of clinical application of these findings is rather slow. As a result, more studies into the practical utility of these findings remain necessary.
PMID
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Authors

Mayor MeshTerms

Genome-Wide Association Study

Keywords
Journal Title journal of diabetes
Publication Year Start




PMID- 22781187
OWN - NLM
STAT- MEDLINE
DCOM- 20130201
LR  - 20120817
IS  - 1753-0407 (Electronic)
IS  - 1753-0407 (Linking)
VI  - 4
IP  - 3
DP  - 2012 Sep
TI  - Genetic advances of type 2 diabetes in Chinese populations.
PG  - 213-20
LID - 10.1111/j.1753-0407.2012.00225.x [doi]
AB  - In recent decades, the prevalence of type 2 diabetes in China has increased
      significantly, underscoring the importance of investigating the etiological
      mechanisms, including genetic determinants, of the disease in Chinese
      populations. Numerous loci conferring susceptibility to type 2 diabetes (T2D)
      have been identified worldwide, with most having been identified in European
      populations. In terms of ethnic heterogeneity in pathogenesis as well as disease 
      predisposition, it is imperative to explore the specific genetic architecture of 
      T2D in Han Chinese. Replication studies of European-derived susceptibility loci
      have been performed, validating 11 of 32 loci in Chinese populations. Genetic
      investigations into heritable traits related to glucose metabolism are expected
      to provide new insights into the pathogenesis of T2D, and such studies have
      already inferred some new susceptibility loci. Other than replication studies of 
      European-derived loci, efforts have been made to identify specific susceptibility
      loci in Chinese populations using methods such as genome-wide association
      studies. These efforts have identified additional new loci for the disease.
      Genetic studies can facilitate the prediction of risk for T2D and also promote
      individualized anti-diabetic treatment. Despite many advances in the field of
      risk prediction and pharmacogenetics, the pace of clinical application of these
      findings is rather slow. As a result, more studies into the practical utility of 
      these findings remain necessary.
CI  - (c) 2012 Ruijin Hospital, Shanghai Jiaotong University School of Medicine and
      Wiley Publishing Asia Pty Ltd.
FAU - Yu, Weihui
AU  - Yu W
AD  - Department of Endocrinology and Metabolism, Shanghai Jiao Tong University,
      Shanghai, China.
FAU - Hu, Cheng
AU  - Hu C
FAU - Jia, Weiping
AU  - Jia W
LA  - eng
PT  - Journal Article
PT  - Review
PL  - Australia
TA  - J Diabetes
JT  - Journal of diabetes
JID - 101504326
RN  - 0 (Hypoglycemic Agents)
SB  - IM
MH  - Asian Continental Ancestry Group/*genetics
MH  - China
MH  - Diabetes Mellitus, Type 2/drug therapy/ethnology/*genetics
MH  - European Continental Ancestry Group/genetics
MH  - Genetic Predisposition to Disease/*genetics
MH  - *Genome-Wide Association Study
MH  - Humans
MH  - Hypoglycemic Agents/therapeutic use
MH  - Pharmacogenetics
EDAT- 2012/07/12 06:00
MHDA- 2013/02/05 06:00
CRDT- 2012/07/12 06:00
PHST- 2012/07/12 06:00 [entrez]
PHST- 2012/07/12 06:00 [pubmed]
PHST- 2013/02/05 06:00 [medline]
AID - 10.1111/j.1753-0407.2012.00225.x [doi]
PST - ppublish
SO  - J Diabetes. 2012 Sep;4(3):213-20. doi: 10.1111/j.1753-0407.2012.00225.x.