PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Positional differences of axon growth rates between sensory neurons encoded by Runx3.

Abstract The formation of functional connectivity in the nervous system is governed by axon guidance that instructs nerve growth and branching during development, implying a similarity between neuronal subtypes in terms of nerve extension. We demonstrate the molecular mechanism of another layer of complexity in vertebrates by defining a transcriptional program underlying growth differences between positionally different neurons. The rate of axon extension of the early subset of embryonic dorsal root ganglion sensory neurons is encoded in neurons at different axial levels. This code is determined by a segmental pattern of axial levels of Runx family transcription factor Runx3. Runx3 in turn determines transcription levels of genes encoding cytoskeletal proteins involved in axon extension, including Rock1 and Rock2 which have ongoing activities determining axon growth in early sensory neurons and blocking Rock activity reverses axon extension deficits of Runx3(-/-) neurons. Thus, Runx3 acts to regulate positional differences in axon extension properties apparently without affecting nerve guidance and branching, a principle that could be relevant to other parts of the nervous system.
PMID
Related Publications

Sox11 regulates survival and axonal growth of embryonic sensory neurons.

Runx transcription factors in neuronal development.

Runx3 is essential for the target-specific axon pathfinding of trkc-expressing dorsal root ganglion neurons.

Dynamic regulation of the expression of neurotrophin receptors by Runx3.

Graded activity of transcription factor Runx3 specifies the laminar termination pattern of sensory axons in the developing spinal cord.

Authors

Mayor MeshTerms

Gene Expression Regulation

Keywords
Journal Title the embo journal
Publication Year Start




PMID- 22903063
OWN - NLM
STAT- MEDLINE
DCOM- 20121203
LR  - 20150223
IS  - 1460-2075 (Electronic)
IS  - 0261-4189 (Linking)
VI  - 31
IP  - 18
DP  - 2012 Sep 12
TI  - Positional differences of axon growth rates between sensory neurons encoded by
      Runx3.
PG  - 3718-29
LID - 10.1038/emboj.2012.228 [doi]
AB  - The formation of functional connectivity in the nervous system is governed by
      axon guidance that instructs nerve growth and branching during development,
      implying a similarity between neuronal subtypes in terms of nerve extension. We
      demonstrate the molecular mechanism of another layer of complexity in vertebrates
      by defining a transcriptional program underlying growth differences between
      positionally different neurons. The rate of axon extension of the early subset of
      embryonic dorsal root ganglion sensory neurons is encoded in neurons at different
      axial levels. This code is determined by a segmental pattern of axial levels of
      Runx family transcription factor Runx3. Runx3 in turn determines transcription
      levels of genes encoding cytoskeletal proteins involved in axon extension,
      including Rock1 and Rock2 which have ongoing activities determining axon growth
      in early sensory neurons and blocking Rock activity reverses axon extension
      deficits of Runx3(-/-) neurons. Thus, Runx3 acts to regulate positional
      differences in axon extension properties apparently without affecting nerve
      guidance and branching, a principle that could be relevant to other parts of the 
      nervous system.
FAU - Lallemend, Francois
AU  - Lallemend F
AD  - Division of Molecular Neurobiology, Department of Medical Biochemistry and
      Biophysics, Karolinska Institute, Stockholm, Sweden. [email protected]
FAU - Sterzenbach, Ulrich
AU  - Sterzenbach U
FAU - Hadjab-Lallemend, Saida
AU  - Hadjab-Lallemend S
FAU - Aquino, Jorge B
AU  - Aquino JB
FAU - Castelo-Branco, Goncalo
AU  - Castelo-Branco G
FAU - Sinha, Indranil
AU  - Sinha I
FAU - Villaescusa, J Carlos
AU  - Villaescusa JC
FAU - Levanon, Ditsa
AU  - Levanon D
FAU - Wang, Yiqiao
AU  - Wang Y
FAU - Franck, Marina C M
AU  - Franck MC
FAU - Kharchenko, Olga
AU  - Kharchenko O
FAU - Adameyko, Igor
AU  - Adameyko I
FAU - Linnarsson, Sten
AU  - Linnarsson S
FAU - Groner, Yoram
AU  - Groner Y
FAU - Turner, Eric
AU  - Turner E
FAU - Ernfors, Patrik
AU  - Ernfors P
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20120817
PL  - England
TA  - EMBO J
JT  - The EMBO journal
JID - 8208664
RN  - 0 (Core Binding Factor Alpha 3 Subunit)
RN  - 0 (Runx3 protein, mouse)
RN  - 63231-63-0 (RNA)
SB  - IM
MH  - Animals
MH  - Axons/metabolism/*physiology
MH  - Cell Proliferation
MH  - Chick Embryo
MH  - Core Binding Factor Alpha 3 Subunit/*metabolism
MH  - Ganglia, Spinal/embryology
MH  - *Gene Expression Regulation
MH  - Mice
MH  - Mice, Transgenic
MH  - Models, Genetic
MH  - Nervous System/embryology
MH  - Neurons/metabolism
MH  - RNA/metabolism
MH  - Sensory Receptor Cells/*physiology
MH  - Time Factors
PMC - PMC3442276
EDAT- 2012/08/21 06:00
MHDA- 2012/12/10 06:00
CRDT- 2012/08/21 06:00
PHST- 2012/03/22 00:00 [received]
PHST- 2012/07/20 00:00 [accepted]
PHST- 2012/08/21 06:00 [entrez]
PHST- 2012/08/21 06:00 [pubmed]
PHST- 2012/12/10 06:00 [medline]
AID - emboj2012228 [pii]
AID - 10.1038/emboj.2012.228 [doi]
PST - ppublish
SO  - EMBO J. 2012 Sep 12;31(18):3718-29. doi: 10.1038/emboj.2012.228. Epub 2012 Aug
      17.