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Copper, zinc, and Cu/Zn ratio in transitional cell carcinoma of the bladder.

Abstract Many epidemiological and experimental studies report a strong role of chemical carcinogens in the etiology of bladder cancer. However, involvement of trace elements in the tumorigenesis of transitional cell carcinoma of the bladder has been poorly investigated. The aim of this study was to examine the relationship between zinc, copper and bladder cancer.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title urologia internationalis
Publication Year Start




PMID- 23006800
OWN - NLM
STAT- MEDLINE
DCOM- 20130425
LR  - 20131121
IS  - 1423-0399 (Electronic)
IS  - 0042-1138 (Linking)
VI  - 89
IP  - 3
DP  - 2012
TI  - Copper, zinc, and Cu/Zn ratio in transitional cell carcinoma of the bladder.
PG  - 342-7
LID - 10.1159/000341976 [doi]
AB  - INTRODUCTION: Many epidemiological and experimental studies report a strong role 
      of chemical carcinogens in the etiology of bladder cancer. However, involvement
      of trace elements in the tumorigenesis of transitional cell carcinoma of the
      bladder has been poorly investigated. The aim of this study was to examine the
      relationship between zinc, copper and bladder cancer. MATERIALS AND METHODS: Zinc
      and copper concentration and Cu/Zn ratio in two 36-sample series of bladder
      cancer tissue and sera from patients with this neoplasm were matched with those
      of the control group. The amount of trace elements in every tissue sample was
      determined using atomic absorption spectrometry. This was correlated with tumor
      stage. RESULTS: While the copper concentrations reached statistically higher
      values in the bladder cancer tissue, the zinc levels in the sera and bladder
      tissue of the patients with this carcinoma were substantially lower as compared
      to those of the control group. The serum Cu/Zn ratio was significantly higher in 
      the bladder cancer group and this increase was greater in the patients with
      muscle-invasive neoplasm. CONCLUSIONS: The results obtained suggest a
      relationship between trace elements and the bladder cancer.
CI  - Copyright (c) 2012 S. Karger AG, Basel.
FAU - Golabek, Tomasz
AU  - Golabek T
AD  - Department of Urology, Medical University of Bialystok, Bialystok, Poland.
      [email protected]
FAU - Darewicz, Barbara
AU  - Darewicz B
FAU - Borawska, Maria
AU  - Borawska M
FAU - Socha, Katarzyna
AU  - Socha K
FAU - Markiewicz, Renata
AU  - Markiewicz R
FAU - Kudelski, Jacek
AU  - Kudelski J
LA  - eng
PT  - Journal Article
DEP - 20120919
PL  - Switzerland
TA  - Urol Int
JT  - Urologia internationalis
JID - 0417373
RN  - 0 (Trace Elements)
RN  - 789U1901C5 (Copper)
RN  - J41CSQ7QDS (Zinc)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Carcinoma, Transitional Cell/*blood
MH  - Copper/*blood
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Spectrophotometry, Atomic/methods
MH  - Trace Elements
MH  - Urinary Bladder Neoplasms/*blood
MH  - Zinc/*blood
EDAT- 2012/09/26 06:00
MHDA- 2013/04/26 06:00
CRDT- 2012/09/26 06:00
PHST- 2012/03/30 00:00 [received]
PHST- 2012/07/18 00:00 [accepted]
PHST- 2012/09/26 06:00 [entrez]
PHST- 2012/09/26 06:00 [pubmed]
PHST- 2013/04/26 06:00 [medline]
AID - 000341976 [pii]
AID - 10.1159/000341976 [doi]
PST - ppublish
SO  - Urol Int. 2012;89(3):342-7. doi: 10.1159/000341976. Epub 2012 Sep 19.