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Impact of maternal diabetes on epigenetic modifications leading to diseases in the offspring.

Abstract Gestational diabetes, occurring during the hyperglycemic period of pregnancy in maternal life, is a pathologic state that increases the incidence of complications in both mother and fetus. Offspring thus exposed to an adverse fetal and early postnatal environment may manifest increased susceptibility to a number of chronic diseases later in life. Compelling evidence for the role of epigenetic transmission in these complications has come from comparison of siblings born before and after the development of maternal diabetes, exposure to this intrauterine diabetic environment being shown to cause alterations in fetal growth patterns which predispose these infants to developing overweight and obesity later in life. Diabetes of the offspring is also mainly the consequence of exposure to the diabetic intrauterine environment, in addition to genetic susceptibility. Since obesity and diabetes are known to increase the risk of cardiovascular disease, cardiovascular sequelae in the offspring of diabetic mothers are virtually inevitable. Research data also suggest that exposure to a diabetic intrauterine environment during pregnancy is associated with an increase in dyslipidemia, subclinical vascular inflammation, and endothelial dysfunction processes in the offspring, all of which are linked with development of cardiovascular disease later in life. The main underlying mechanisms involve persistent hyperglycemia hyperinsulinemia and leptin resistance.
PMID
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Authors

Mayor MeshTerms

Epigenesis, Genetic

Prenatal Exposure Delayed Effects

Keywords
Journal Title experimental diabetes research
Publication Year Start




PMID- 23227034
OWN - NLM
STAT- MEDLINE
DA  - 20121211
DCOM- 20130514
LR  - 20150219
IS  - 1687-5303 (Electronic)
IS  - 1687-5214 (Linking)
VI  - 2012
DP  - 2012
TI  - Impact of maternal diabetes on epigenetic modifications leading to diseases in
      the offspring.
PG  - 538474
LID - 10.1155/2012/538474 [doi]
AB  - Gestational diabetes, occurring during the hyperglycemic period of pregnancy in
      maternal life, is a pathologic state that increases the incidence of
      complications in both mother and fetus. Offspring thus exposed to an adverse
      fetal and early postnatal environment may manifest increased susceptibility to a 
      number of chronic diseases later in life. Compelling evidence for the role of
      epigenetic transmission in these complications has come from comparison of
      siblings born before and after the development of maternal diabetes, exposure to 
      this intrauterine diabetic environment being shown to cause alterations in fetal 
      growth patterns which predispose these infants to developing overweight and
      obesity later in life. Diabetes of the offspring is also mainly the consequence
      of exposure to the diabetic intrauterine environment, in addition to genetic
      susceptibility. Since obesity and diabetes are known to increase the risk of
      cardiovascular disease, cardiovascular sequelae in the offspring of diabetic
      mothers are virtually inevitable. Research data also suggest that exposure to a
      diabetic intrauterine environment during pregnancy is associated with an increase
      in dyslipidemia, subclinical vascular inflammation, and endothelial dysfunction
      processes in the offspring, all of which are linked with development of
      cardiovascular disease later in life. The main underlying mechanisms involve
      persistent hyperglycemia hyperinsulinemia and leptin resistance.
FAU - Vrachnis, Nikolaos
AU  - Vrachnis N
AD  - 2nd Department of Obstetrics and Gynecology, Aretaieion Hospital, University of
      Athens Medical School, 11528 Athens, Greece. [email protected]
FAU - Antonakopoulos, Nikolaos
AU  - Antonakopoulos N
FAU - Iliodromiti, Zoe
AU  - Iliodromiti Z
FAU - Dafopoulos, Konstantinos
AU  - Dafopoulos K
FAU - Siristatidis, Charalambos
AU  - Siristatidis C
FAU - Pappa, Kalliopi I
AU  - Pappa KI
FAU - Deligeoroglou, Efthymios
AU  - Deligeoroglou E
FAU - Vitoratos, Nicolaos
AU  - Vitoratos N
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20121122
PL  - United States
TA  - Exp Diabetes Res
JT  - Experimental diabetes research
JID - 101274844
RN  - 0 (Blood Glucose)
SB  - IM
MH  - Animals
MH  - Blood Glucose/metabolism
MH  - Cardiovascular Diseases/blood/*genetics/physiopathology
MH  - Chronic Disease
MH  - Diabetes Mellitus, Type 2/blood/*genetics/physiopathology
MH  - Diabetes, Gestational/blood/*genetics/physiopathology
MH  - *Epigenesis, Genetic
MH  - Female
MH  - Fetus/metabolism
MH  - Genetic Predisposition to Disease
MH  - Humans
MH  - Obesity/blood/*genetics
MH  - Phenotype
MH  - Pregnancy
MH  - *Prenatal Exposure Delayed Effects
MH  - Risk Factors
PMC - PMC3512252
OID - NLM: PMC3512252
EDAT- 2012/12/12 06:00
MHDA- 2013/05/15 06:00
CRDT- 2012/12/11 06:00
PHST- 2012/09/18 [received]
PHST- 2012/10/26 [accepted]
PHST- 2012/11/22 [epublish]
AID - 10.1155/2012/538474 [doi]
PST - ppublish
SO  - Exp Diabetes Res. 2012;2012:538474. doi: 10.1155/2012/538474. Epub 2012 Nov 22.

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