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The effect of a supersaturated calcium phosphate mouth rinse on the development of oral mucositis in head and neck cancer patients treated with (chemo)radiation: a single-center, randomized, prospective study of a calcium phosphate mouth rinse + standard of care versus standard of care.

Abstract Mucosal damage is an important and debilitating side effect when treating head and neck cancer patients with (chemo-)radiation. The aim of this randomized clinical trial was to investigate whether the addition of a neutral, supersaturated, calcium phosphate (CP) mouth rinse benefits the severity and duration of acute mucositis in head and neck cancer patients treated with (chemo)radiation.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title supportive care in cancer : official journal of the multinational association of supportive care in cancer
Publication Year Start




PMID- 23686379
OWN - NLM
STAT- MEDLINE
DA  - 20130909
DCOM- 20140407
LR  - 20130909
IS  - 1433-7339 (Electronic)
IS  - 0941-4355 (Linking)
VI  - 21
IP  - 10
DP  - 2013 Oct
TI  - The effect of a supersaturated calcium phosphate mouth rinse on the development
      of oral mucositis in head and neck cancer patients treated with (chemo)radiation:
      a single-center, randomized, prospective study of a calcium phosphate mouth rinse
      + standard of care versus standard of care.
PG  - 2663-70
LID - 10.1007/s00520-013-1829-0 [doi]
AB  - OBJECTIVES: Mucosal damage is an important and debilitating side effect when
      treating head and neck cancer patients with (chemo-)radiation. The aim of this
      randomized clinical trial was to investigate whether the addition of a neutral,
      supersaturated, calcium phosphate (CP) mouth rinse benefits the severity and
      duration of acute mucositis in head and neck cancer patients treated with
      (chemo)radiation. MATERIALS AND METHODS: A total of 60 patients with malignant
      neoplasms of the head and neck receiving (chemo)radiation were included in this
      study. Fifty-eight patients were randomized into two treatment arms: a control
      group receiving standard of care (n = 31) and a study group receiving standard of
      care + daily CP mouth rinses (n = 27) starting on the first day of
      (chemo-)radiation. Oral mucositis and dysphagia were assessed twice a week using 
      the National Cancer Institute common toxicity criteria scale version 3, oral pain
      was scored with a visual analogue scale. RESULTS: No significant difference in
      grade III mucositis (59 vs. 71 %; p = 0.25) and dysphagia (33 vs. 42 %, p = 0.39)
      was observed between the study group compared to the control group. Also no
      significant difference in time until development of peak mucositis (28.6 vs. 28.7
      days; p = 0.48), duration of peak mucositis (22.7 vs. 24.6 days; p = 0.31),
      recuperation of peak dysphagia (20.5 vs 24.2 days; p = 0.13) and occurrence of
      severe pain (56 vs. 52 %, p = 0.5). CONCLUSION: In this randomized study, the
      addition of CP mouth rinse to standard of care did not improve the frequency,
      duration or severity of the most common acute toxicities during and early after
      (chemo)radiation. There is currently no evidence supporting its standard use in
      daily practice.
FAU - Lambrecht, Maarten
AU  - Lambrecht M
AD  - Department of Radiation-Oncology, University Hospitals Leuven, Campus
      Gasthuisberg, Leuven, Belgium.
FAU - Mercier, Carole
AU  - Mercier C
FAU - Geussens, Yasmyne
AU  - Geussens Y
FAU - Nuyts, Sandra
AU  - Nuyts S
LA  - ENG
PT  - Journal Article
PT  - Randomized Controlled Trial
DEP - 20130518
PL  - Germany
TA  - Support Care Cancer
JT  - Supportive care in cancer : official journal of the Multinational Association of 
      Supportive Care in Cancer
JID - 9302957
RN  - 0 (Calcium Phosphates)
RN  - 0 (Mouthwashes)
RN  - 97Z1WI3NDX (calcium phosphate)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Calcium Phosphates/*administration & dosage
MH  - Chemoradiotherapy/adverse effects
MH  - Female
MH  - Head and Neck Neoplasms/*drug therapy/*radiotherapy
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Mouth Mucosa/drug effects/radiation effects
MH  - Mouthwashes/administration & dosage
MH  - Pain/drug therapy
MH  - Pain Measurement
MH  - Prospective Studies
MH  - Radiation Injuries/drug therapy/etiology
MH  - Standard of Care
MH  - Stomatitis/chemically induced/*drug therapy
EDAT- 2013/05/21 06:00
MHDA- 2014/04/08 06:00
CRDT- 2013/05/21 06:00
PHST- 2012/12/11 [received]
PHST- 2013/04/21 [accepted]
AID - 10.1007/s00520-013-1829-0 [doi]
PST - ppublish
SO  - Support Care Cancer. 2013 Oct;21(10):2663-70. doi: 10.1007/s00520-013-1829-0.
      Epub 2013 May 18.

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