PubTransformer

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PMID- 24021593
OWN - NLM
STAT- MEDLINE
DA  - 20131202
DCOM- 20140728
LR  - 20151119
IS  - 1619-3997 (Electronic)
IS  - 0300-5577 (Linking)
VI  - 42
IP  - 1
DP  - 2014 Jan
TI  - Fetal volume at 11-14 gestational weeks: reference ranges and association with
      first trimester biochemical and biophysical markers.
PG  - 107-12
LID - 10.1515/jpm-2013-0158 [doi]
LID - /j/jpme.2014.42.issue-1/jpm-2013-0158/jpm-2013-0158.xml [pii]
AB  - AIMS: To establish reference ranges for fetal volume (FV) measured by
      three-dimensional ultrasound (3D-US) at 11-14 weeks of gestation and to examine
      the possible association of FV with maternal/pregnancy characteristics and
      biochemical parameters. METHODS: Prospective observational study on 240 fetuses
      at 11-14 weeks. FV was measured by 3D-US using Virtual Organ Computer-Aided
      Analysis. Pearson correlation coefficient (cc) and regression analysis were used.
      RESULTS: FV increased exponentially with crown rump length and was unrelated to
      maternal weight (cc=-0.137, P=0.071), age (cc=0.009, P=0.899), parity (0.76),
      smoking status (t-test, P=0.149) and mode of conception (t-test, P=0.8). Z-scores
      (z) of FV was not associated with z-mean uterine artery pulsatility index
      (cc=-0.026, P=0.733), log10 multiples of the median (MoM) free beta human
      chorionic gonadotrophin (cc=0.002, P=0.982), delta value (d) of nuchal
      translucency (cc=0.072, P=0.331) and d-fetal heart rate (cc=0.009, P=0.902), z-FV
      was significantly positively correlated with log10 MoM pregnancy associated
      plasma protein-A (PAPP-A; regression coefficient=1.420976, R2=0.0957, P<0.0001). 
      CONCLUSIONS: FV is strongly related to PAPP-A even after adjustment for crown
      rump length with a mechanism unrelated to placental perfusion. FV is independent 
      of the vast majority of first trimester parameters; hence, it is a promising
      marker of early fetal growth.
FAU - Papastefanou, Ioannis
AU  - Papastefanou I
FAU - Kappou, Dimitra
AU  - Kappou D
FAU - Souka, Athena P
AU  - Souka AP
FAU - Chrelias, Charalambos
AU  - Chrelias C
FAU - Siristatidis, Charalambos
AU  - Siristatidis C
FAU - Pilalis, Athanasios
AU  - Pilalis A
FAU - Kassanos, Demetrios
AU  - Kassanos D
LA  - eng
PT  - Journal Article
PT  - Observational Study
PL  - Germany
TA  - J Perinat Med
JT  - Journal of perinatal medicine
JID - 0361031
RN  - 0 (Biomarkers)
RN  - 0 (Chorionic Gonadotropin, beta Subunit, Human)
RN  - EC 3.4.24.- (Pregnancy-Associated Plasma Protein-A)
RN  - EC 3.4.24.79 (PAPPA1 protein, human)
SB  - IM
MH  - Adult
MH  - Biomarkers/blood
MH  - Chorionic Gonadotropin, beta Subunit, Human/blood
MH  - Cross-Sectional Studies
MH  - Female
MH  - Fetal Development/*physiology
MH  - Gestational Age
MH  - Heart Rate, Fetal
MH  - Humans
MH  - Image Interpretation, Computer-Assisted
MH  - Imaging, Three-Dimensional
MH  - Nuchal Translucency Measurement
MH  - Pregnancy
MH  - Pregnancy Trimester, First/blood/*physiology
MH  - Pregnancy-Associated Plasma Protein-A/metabolism
MH  - Prospective Studies
MH  - Pulsatile Flow
MH  - Reference Values
MH  - Regression Analysis
MH  - *Ultrasonography, Prenatal/methods
MH  - Uterine Artery/physiology
EDAT- 2013/09/12 06:00
MHDA- 2014/07/30 06:00
CRDT- 2013/09/12 06:00
PHST- 2013/06/30 [received]
PHST- 2013/08/15 [accepted]
AID - 10.1515/jpm-2013-0158 [doi]
AID - /j/jpme.ahead-of-print/jpm-2013-0158/jpm-2013-0158.xml [pii]
PST - ppublish
SO  - J Perinat Med. 2014 Jan;42(1):107-12. doi: 10.1515/jpm-2013-0158.

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