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Combined detections of interleukin 27, interferon-γ, and adenosine deaminase in pleural effusion for diagnosis of tuberculous pleurisy.

Abstract Previous studies reported interleukin-27 (IL-27), interferon-γ (IFN-γ), or adenosine deaminase (ADA) alone plays a helpful role in diagnosing tuberculous pleural effusion (TPE). The present study aims at comparing the diagnostic accuracy of pleural IL-27, IFN-γ, and ADA, and investigate the diagnostic accuracy of the combination of IL-27, IFN-γ, or/and ADA for differentiating TPE from pleural effusions with the other etiologies.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title chinese medical journal
Publication Year Start




PMID- 24033939
OWN - NLM
STAT- MEDLINE
DA  - 20130916
DCOM- 20140407
LR  - 20130916
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 126
IP  - 17
DP  - 2013
TI  - Combined detections of interleukin 27, interferon-gamma, and adenosine deaminase 
      in pleural effusion for diagnosis of tuberculous pleurisy.
PG  - 3215-21
AB  - BACKGROUND: Previous studies reported interleukin-27 (IL-27), interferon-gamma
      (IFN-gamma), or adenosine deaminase (ADA) alone plays a helpful role in
      diagnosing tuberculous pleural effusion (TPE). The present study aims at
      comparing the diagnostic accuracy of pleural IL-27, IFN-gamma, and ADA, and
      investigate the diagnostic accuracy of the combination of IL-27, IFN-gamma,
      or/and ADA for differentiating TPE from pleural effusions with the other
      etiologies. METHODS: The concentrations of IL-27, IFN-gamma and ADA were
      simultaneously determined in pleural fluids and sera from 40 patients with TPE;
      26 with malignant pleural effusion, seven with infectious pleural effusion, and
      eight with transudative pleural effusion by enzyme linked immunosorbent assay and
      colorimetric method. The corresponding biochemical indexs were also
      simultaneously determined. RESULTS: The concentrations of pleural IL-27 and
      IFN-gamma in the tuberculous group were significantly higher than those in the
      malignant, infectious, and transudative groups. The concentrations of ADA in TPE 
      were significantly higher than those in MPE or transudative effusions, while much
      lower than those in infectious effusions. Among these three biomarkers, IL-27 was
      the most effective for TPE diagnosis, with the cut off value of 900.8 ng/L. IL-27
      had a high sensitivity of 95% and specificity of 97.6% for differential diagnosis
      of TPE from non-TPEs. Combinations of IL-27, IFN-gamma and ADA measurements
      further increased the sensitivity or specificity up to 100%. CONCLUSIONS:
      Compared to non-TPEs, IL-27, IFN-gamma and ADA all simultaneously increased in
      TPE; and among these three rapid detection methods, IL-27 appeared to be the best
      for distinguishing tuberculous from non-TPEs, especially from MPE. Combinations
      of the three markers (IL-27, IFN-gamma and ADA) yielded the highest sensitivity
      and specificity. These findings suggest that the applications of a new biomarker,
      IL-27, alone or with IFN-gamma and ADA, may contribute to more efficient
      diagnosis strategies in the management of tuberculous pleurisy.
FAU - Wu, Yan-Bin
AU  - Wu YB
AD  - Institute of Respiratory Diseases, First Affiliated Hospital, Guangxi Medical
      University, Nanning, Guangxi 530021, China.
FAU - Ye, Zhi-Jian
AU  - Ye ZJ
FAU - Qin, Sou-Ming
AU  - Qin SM
FAU - Wu, Cong
AU  - Wu C
FAU - Chen, Yi-Qiang
AU  - Chen YQ
FAU - Shi, Huan-Zhong
AU  - Shi HZ
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Interleukin-27)
RN  - 82115-62-6 (Interferon-gamma)
RN  - EC 3.5.4.4 (Adenosine Deaminase)
SB  - IM
MH  - Adenosine Deaminase/blood/*metabolism
MH  - Aged
MH  - Female
MH  - Humans
MH  - Interferon-gamma/blood/*metabolism
MH  - Interleukin-27/blood/*metabolism
MH  - Male
MH  - Middle Aged
MH  - Pleural Effusion/blood/*metabolism
MH  - Tuberculosis, Pleural/blood/*diagnosis/*metabolism
EDAT- 2013/09/17 06:00
MHDA- 2014/04/08 06:00
CRDT- 2013/09/17 06:00
PST - ppublish
SO  - Chin Med J (Engl). 2013;126(17):3215-21.