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%A Gensicke, Henrik; Zinkstok, Sanne M.; Roos, Yvo B.; Seiffge, David J.; Ringleb, Peter; Artto, Ville; Putaala, Jukka; Haapaniemi, Elena; Leys, Didier; Bordet, R?gis; Michel, Patrik; Odier, C?line; Berrouschot, J?rg; Arnold, Marcel; Heldner, Mirjam R.; Zini, Andrea; Bigliardi, Guido; Padjen, Visnja; Peters, Nils; Pezzini, Alessandro; Schindler, Christian; Sarikaya, Hakan; Bonati, Leo H.; Tatlisumak, Turgut; Lyrer, Philippe A.; Nederkoorn, Paul J.; Engelter, Stefan T.
%T IV thrombolysis and renal function.
%J Neurology, vol. 81, no. 20, pp. 1780-1788
%D 11/2013
%V 81
%N 20
%M eng
%B To investigate the association of renal impairment on functional outcome and complications in stroke patients treated with IV thrombolysis (IVT).
%K Aged, Aged, 80 and over, Europe, Female, Glomerular Filtration Rate, Humans, Intracranial Hemorrhages, Magnetic Resonance Imaging, Male, Middle Aged, Regression Analysis, Renal Insufficiency, Retrospective Studies, Severity of Illness Index, Stroke, Thrombolytic Therapy, Tomography, X-Ray Computed
%P 1780
%L 1788
%Y 10.1212/01.wnl.0000435550.83200.9e
%R 2013.......81.1780G

author="Gensicke, Henrik
and Zinkstok, Sanne M.
and Roos, Yvo B.
and Seiffge, David J.
and Ringleb, Peter
and Artto, Ville
and Putaala, Jukka
and Haapaniemi, Elena
and Leys, Didier
and Bordet, R{\'e}gis
and Michel, Patrik
and Odier, C{\'e}line
and Berrouschot, J{\"o}rg
and Arnold, Marcel
and Heldner, Mirjam R.
and Zini, Andrea
and Bigliardi, Guido
and Padjen, Visnja
and Peters, Nils
and Pezzini, Alessandro
and Schindler, Christian
and Sarikaya, Hakan
and Bonati, Leo H.
and Tatlisumak, Turgut
and Lyrer, Philippe A.
and Nederkoorn, Paul J.
and Engelter, Stefan T.",
title="IV thrombolysis and renal function.",
keywords="Aged, 80 and over",
keywords="Glomerular Filtration Rate",
keywords="Intracranial Hemorrhages",
keywords="Magnetic Resonance Imaging",
keywords="Middle Aged",
keywords="Regression Analysis",
keywords="Renal Insufficiency",
keywords="Retrospective Studies",
keywords="Severity of Illness Index",
keywords="Thrombolytic Therapy",
keywords="Tomography, X-Ray Computed",
abstract="To investigate the association of renal impairment on functional outcome and complications in stroke patients treated with IV thrombolysis (IVT).",

%0 Journal Article
%T IV thrombolysis and renal function.
%A Gensicke, Henrik
%A Zinkstok, Sanne M.
%A Roos, Yvo B.
%A Seiffge, David J.
%A Ringleb, Peter
%A Artto, Ville
%A Putaala, Jukka
%A Haapaniemi, Elena
%A Leys, Didier
%A Bordet, R?gis
%A Michel, Patrik
%A Odier, C?line
%A Berrouschot, J?rg
%A Arnold, Marcel
%A Heldner, Mirjam R.
%A Zini, Andrea
%A Bigliardi, Guido
%A Padjen, Visnja
%A Peters, Nils
%A Pezzini, Alessandro
%A Schindler, Christian
%A Sarikaya, Hakan
%A Bonati, Leo H.
%A Tatlisumak, Turgut
%A Lyrer, Philippe A.
%A Nederkoorn, Paul J.
%A Engelter, Stefan T.
%J Neurology
%D 2013
%8 Nov 12
%V 81
%N 20
%@ 1526-632X
%G eng
%F Gensicke2013
%X To investigate the association of renal impairment on functional outcome and complications in stroke patients treated with IV thrombolysis (IVT).
%K Aged
%K Aged, 80 and over
%K Europe
%K Female
%K Glomerular Filtration Rate
%K Humans
%K Intracranial Hemorrhages
%K Magnetic Resonance Imaging
%K Male
%K Middle Aged
%K Regression Analysis
%K Renal Insufficiency
%K Retrospective Studies
%K Severity of Illness Index
%K Stroke
%K Thrombolytic Therapy
%K Tomography, X-Ray Computed
%P 1780-1788

PT Journal
AU Gensicke, H
   Zinkstok, SM
   Roos, YB
   Seiffge, DJ
   Ringleb, P
   Artto, V
   Putaala, J
   Haapaniemi, E
   Leys, D
   Bordet, R
   Michel, P
   Odier, C
   Berrouschot, J
   Arnold, M
   Heldner, MR
   Zini, A
   Bigliardi, G
   Padjen, V
   Peters, N
   Pezzini, A
   Schindler, C
   Sarikaya, H
   Bonati, LH
   Tatlisumak, T
   Lyrer, PA
   Nederkoorn, PJ
   Engelter, ST
TI IV thrombolysis and renal function.
SO Neurology
PD Nov
PY 2013
BP 1780
EP 1788
VL 81
IS 20
DI 10.1212/01.wnl.0000435550.83200.9e
LA eng
DE Aged; Aged, 80 and over; Europe; Female; Glomerular Filtration Rate; Humans; Intracranial Hemorrhages; Magnetic Resonance Imaging; Male; Middle Aged; Regression Analysis; Renal Insufficiency; Retrospective Studies; Severity of Illness Index; Stroke; Thrombolytic Therapy; Tomography, X-Ray Computed
AB To investigate the association of renal impairment on functional outcome and complications in stroke patients treated with IV thrombolysis (IVT).

PMID- 24122182
DA  - 20131112
DCOM- 20131230
IS  - 1526-632X (Electronic)
IS  - 0028-3878 (Linking)
VI  - 81
IP  - 20
DP  - 2013 Nov 12
TI  - IV thrombolysis and renal function.
PG  - 1780-8
LID - 10.1212/01.wnl.0000435550.83200.9e [doi]
AB  - OBJECTIVE: To investigate the association of renal impairment on functional
      outcome and complications in stroke patients treated with IV thrombolysis (IVT). 
      METHODS: In this observational study, we compared the estimated glomerular
      filtration rate (GFR) with poor 3-month outcome (modified Rankin Scale scores
      3-6), death, and symptomatic intracranial hemorrhage (sICH) based on the criteria
      of the European Cooperative Acute Stroke Study II trial. Unadjusted and adjusted 
      odds ratios (ORs) with 95% confidence intervals (CIs) were calculated. Patients
      without IVT treatment served as a comparison group. RESULTS: Among 4,780
      IVT-treated patients, 1,217 (25.5%) had a low GFR (<60 mL/min/1.73 m(2)). A GFR
      decrease by 10 mL/min/1.73 m(2) increased the risk of poor outcome (OR [95% CI]):
      (ORunadjusted 1.20 [1.17-1.24]; ORadjusted 1.05 [1.01-1.09]), death (ORunadjusted
      1.33 [1.28-1.38]; ORadjusted 1.18 [1.11-1.249]), and sICH (ORunadjusted 1.15
      [1.01-1.22]; ORadjusted 1.11 [1.04-1.20]). Low GFR was independently associated
      with poor 3-month outcome (ORadjusted 1.32 [1.10-1.58]), death (ORadjusted 1.73
      [1.39-2.14]), and sICH (ORadjusted 1.64 [1.21-2.23]) compared with normal GFR
      (60-120 mL/min/1.73 m(2)). Low GFR (ORadjusted 1.64 [1.21-2.23]) and stroke
      severity (ORadjusted 1.05 [1.03-1.07]) independently determined sICH. Compared
      with patients who did not receive IVT, treatment with IVT in patients with low
      GFR was associated with poor outcome (ORadjusted 1.79 [1.41-2.25]), and with
      favorable outcome in those with normal GFR (ORadjusted 0.77 [0.63-0.94]).
      CONCLUSION: Renal function significantly modified outcome and complication rates 
      in IVT-treated stroke patients. Lower GFR might be a better risk indicator for
      sICH than age. A decrease of GFR by 10 mL/min/1.73 m(2) seems to have a similar
      impact on the risk of death or sICH as a 1-point-higher NIH Stroke Scale score
      measuring stroke severity.
FAU - Gensicke, Henrik
AU  - Gensicke H
AD  - From the Departments of Neurology (H.G., D.J.S., N.P., L.H.B., P.A.L., S.T.E.),
      University Hospital Basel, Switzerland; Academic Medical Center (S.M.Z., Y.B.R., 
      P.J.N.), University of Amsterdam, the Netherlands; University of Heidelberg
      (P.R.), Germany; Helsinki University Central Hospital (V.A., J.P., E.H., T.T.),
      Finland; University Lille North de France (D.L., R.B.), UDSL (EA1046), France;
      Centre Hospitalier Universitaire Vaudois and University of Lausanne (P.M., C.O.),
      Switzerland; Municipal Hospital Altenburg (J.B.), Germany; University Hospital
      Bern (M.A., M.R.H., H.S.), Switzerland; AUSL Modena (A.Z., G.B.), Italy; Clinical
      Center (V.P.), School of Medicine, University of Belgrade, Serbia; University
      Hospital Brescia (A.P.), Italy; Swiss Tropical and Public Health Institute
      (C.S.), University of Basel, Switzerland; University Hospital Zurich (H.S.),
FAU - Zinkstok, Sanne M
AU  - Zinkstok SM
FAU - Roos, Yvo B
AU  - Roos YB
FAU - Seiffge, David J
AU  - Seiffge DJ
FAU - Ringleb, Peter
AU  - Ringleb P
FAU - Artto, Ville
AU  - Artto V
FAU - Putaala, Jukka
AU  - Putaala J
FAU - Haapaniemi, Elena
AU  - Haapaniemi E
FAU - Leys, Didier
AU  - Leys D
FAU - Bordet, Regis
AU  - Bordet R
FAU - Michel, Patrik
AU  - Michel P
FAU - Odier, Celine
AU  - Odier C
FAU - Berrouschot, Jorg
AU  - Berrouschot J
FAU - Arnold, Marcel
AU  - Arnold M
FAU - Heldner, Mirjam R
AU  - Heldner MR
FAU - Zini, Andrea
AU  - Zini A
FAU - Bigliardi, Guido
AU  - Bigliardi G
FAU - Padjen, Visnja
AU  - Padjen V
FAU - Peters, Nils
AU  - Peters N
FAU - Pezzini, Alessandro
AU  - Pezzini A
FAU - Schindler, Christian
AU  - Schindler C
FAU - Sarikaya, Hakan
AU  - Sarikaya H
FAU - Bonati, Leo H
AU  - Bonati LH
FAU - Tatlisumak, Turgut
AU  - Tatlisumak T
FAU - Lyrer, Philippe A
AU  - Lyrer PA
FAU - Nederkoorn, Paul J
AU  - Nederkoorn PJ
FAU - Engelter, Stefan T
AU  - Engelter ST
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131011
PL  - United States
TA  - Neurology
JT  - Neurology
JID - 0401060
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Europe
MH  - Female
MH  - Glomerular Filtration Rate/drug effects
MH  - Humans
MH  - Intracranial Hemorrhages/chemically induced
MH  - Magnetic Resonance Imaging
MH  - Male
MH  - Middle Aged
MH  - Regression Analysis
MH  - Renal Insufficiency/*chemically induced
MH  - Retrospective Studies
MH  - Severity of Illness Index
MH  - Stroke/drug therapy
MH  - Thrombolytic Therapy/*adverse effects
MH  - Tomography, X-Ray Computed
EDAT- 2013/10/15 06:00
MHDA- 2014/01/01 06:00
CRDT- 2013/10/15 06:00
PHST- 2013/10/11 [aheadofprint]
AID - 01.wnl.0000435550.83200.9e [pii]
AID - 10.1212/01.wnl.0000435550.83200.9e [doi]
PST - ppublish
SO  - Neurology. 2013 Nov 12;81(20):1780-8. doi: 10.1212/01.wnl.0000435550.83200.9e.
      Epub 2013 Oct 11.
AU  - Gensicke, Henrik
AU  - Zinkstok, Sanne M.
AU  - Roos, Yvo B.
AU  - Seiffge, David J.
AU  - Ringleb, Peter
AU  - Artto, Ville
AU  - Putaala, Jukka
AU  - Haapaniemi, Elena
AU  - Leys, Didier
AU  - Bordet, R?gis
AU  - Michel, Patrik
AU  - Odier, C?line
AU  - Berrouschot, J?rg
AU  - Arnold, Marcel
AU  - Heldner, Mirjam R.
AU  - Zini, Andrea
AU  - Bigliardi, Guido
AU  - Padjen, Visnja
AU  - Peters, Nils
AU  - Pezzini, Alessandro
AU  - Schindler, Christian
AU  - Sarikaya, Hakan
AU  - Bonati, Leo H.
AU  - Tatlisumak, Turgut
AU  - Lyrer, Philippe A.
AU  - Nederkoorn, Paul J.
AU  - Engelter, Stefan T.
PY  - 2013/Nov/12
TI  - IV thrombolysis and renal function.
JO  - Neurology
SP  - 1780
EP  - 1788
VL  - 81
IS  - 20
KW  - Aged
KW  - Aged, 80 and over
KW  - Europe
KW  - Female
KW  - Glomerular Filtration Rate
KW  - Humans
KW  - Intracranial Hemorrhages
KW  - Magnetic Resonance Imaging
KW  - Male
KW  - Middle Aged
KW  - Regression Analysis
KW  - Renal Insufficiency
KW  - Retrospective Studies
KW  - Severity of Illness Index
KW  - Stroke
KW  - Thrombolytic Therapy
KW  - Tomography, X-Ray Computed
N2  - To investigate the association of renal impairment on functional outcome and complications in stroke patients treated with IV thrombolysis (IVT).
SN  - 1526-632X
UR  -
UR  -
ID  - Gensicke2013
ER  - 
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