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Colonization of an acid resistant Kingella denitrificans in the stomach may contribute to gastric dysbiosis by Helicobacter pylori.

Abstract In the stomach of a gastric ulcer patient who had been administered an anti-acid, a gram-negative and urease-negative bacillus similar in size to Helicobacter pylori was infected together with H. pylori. According to biochemical test and 16S rRNA gene analysis, the urease-negative bacterium was identified as Kingella denitrificans, a human nasopharyngeal commensal. In contrast to the standard strain of K. denitrificans, the isolate showed catalase activity, did not produce acid from glucose, and exhibited acid tolerance. Acid tolerance of H. pylori was increased by cocultivation with the K. denitrificans isolate, but not with other isolates of K. denitrificans. Disruption of physiological and immunological niche by dysbiotic colonization of bacterium may provide pathological attributes to human stomach. Collectively, a careful administration of anti-acids to the elderly, especially those with atrophic gastritis, is necessary to avoid repression of the gastric barrier to bacteria.
PMID
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Authors

Mayor MeshTerms
Keywords

Anti-acid administration

Dysbiosis

Gastric barrier to bacteria

Helicobacter pylori

Kingella denitrificans

Journal Title journal of infection and chemotherapy : official journal of the japan society of chemotherapy
Publication Year Start




PMID- 24462438
OWN - NLM
STAT- MEDLINE
DCOM- 20141231
LR  - 20140328
IS  - 1437-7780 (Electronic)
IS  - 1341-321X (Linking)
VI  - 20
IP  - 3
DP  - 2014 Mar
TI  - Colonization of an acid resistant Kingella denitrificans in the stomach may
      contribute to gastric dysbiosis by Helicobacter pylori.
PG  - 169-74
LID - 10.1016/j.jiac.2013.09.007 [doi]
LID - S1341-321X(13)00036-6 [pii]
AB  - In the stomach of a gastric ulcer patient who had been administered an anti-acid,
      a gram-negative and urease-negative bacillus similar in size to Helicobacter
      pylori was infected together with H. pylori. According to biochemical test and
      16S rRNA gene analysis, the urease-negative bacterium was identified as Kingella 
      denitrificans, a human nasopharyngeal commensal. In contrast to the standard
      strain of K. denitrificans, the isolate showed catalase activity, did not produce
      acid from glucose, and exhibited acid tolerance. Acid tolerance of H. pylori was 
      increased by cocultivation with the K. denitrificans isolate, but not with other 
      isolates of K. denitrificans. Disruption of physiological and immunological niche
      by dysbiotic colonization of bacterium may provide pathological attributes to
      human stomach. Collectively, a careful administration of anti-acids to the
      elderly, especially those with atrophic gastritis, is necessary to avoid
      repression of the gastric barrier to bacteria.
CI  - Copyright (c) 2013 Japanese Society of Chemotherapy and The Japanese Association 
      for Infectious Diseases. Published by Elsevier Ltd. All rights reserved.
FAU - Okamoto, Takeshi
AU  - Okamoto T
AD  - Yamaguchi University, Graduate School of Medicine, Minamikogushi 1-1-1, Ube,
      Yamaguchi 755-8505, Japan.
FAU - Hayashi, Yasuhiro
AU  - Hayashi Y
AD  - Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo,
      Hokkaido 060-0815, Japan.
FAU - Mizuno, Hidekazu
AU  - Mizuno H
AD  - Clinical Laboratory, Yamaguchi University Hospital, Minamikogushi 1-1-1, Ube,
      Yamaguchi 755-8505, Japan.
FAU - Yanai, Hideo
AU  - Yanai H
AD  - Department of Clinical Research, National Hospital Organization Kanmon Medical
      Center, 1-1 Sotoura, Chofu, Shimonoseki, Yamaguchi 752-8510, Japan.
FAU - Nishikawa, Jun
AU  - Nishikawa J
AD  - Yamaguchi University, Graduate School of Medicine, Minamikogushi 1-1-1, Ube,
      Yamaguchi 755-8505, Japan.
FAU - Nakazawa, Teruko
AU  - Nakazawa T
AD  - Yamaguchi University, Graduate School of Medicine, Minamikogushi 1-1-1, Ube,
      Yamaguchi 755-8505, Japan.
FAU - Iizasa, Hisashi
AU  - Iizasa H
AD  - Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo,
      Hokkaido 060-0815, Japan.
FAU - Jinushi, Masahisa
AU  - Jinushi M
AD  - Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo,
      Hokkaido 060-0815, Japan.
FAU - Sakaida, Isao
AU  - Sakaida I
AD  - Yamaguchi University, Graduate School of Medicine, Minamikogushi 1-1-1, Ube,
      Yamaguchi 755-8505, Japan.
FAU - Yoshiyama, Hironori
AU  - Yoshiyama H
AD  - Institute for Genetic Medicine, Hokkaido University, N15 W7, Kita-ku, Sapporo,
      Hokkaido 060-0815, Japan. Electronic address: [email protected]
LA  - eng
PT  - Case Reports
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20131211
PL  - Netherlands
TA  - J Infect Chemother
JT  - Journal of infection and chemotherapy : official journal of the Japan Society of 
      Chemotherapy
JID - 9608375
RN  - 0 (Anti-Ulcer Agents)
RN  - 884KT10YB7 (Ranitidine)
SB  - IM
MH  - Aged
MH  - Anti-Ulcer Agents/adverse effects/therapeutic use
MH  - Biopsy
MH  - Carrier State/diagnosis/*microbiology
MH  - Gastric Mucosa/cytology/microbiology/pathology
MH  - Helicobacter Infections/diagnosis/microbiology
MH  - Helicobacter pylori
MH  - Humans
MH  - Hydrogen-Ion Concentration
MH  - Kingella/*isolation & purification/physiology
MH  - Male
MH  - Microbial Viability
MH  - Neisseriaceae Infections/diagnosis/*microbiology
MH  - Ranitidine/adverse effects/therapeutic use
MH  - Stomach Ulcer/drug therapy/*microbiology
OTO - NOTNLM
OT  - Anti-acid administration
OT  - Dysbiosis
OT  - Gastric barrier to bacteria
OT  - Helicobacter pylori
OT  - Kingella denitrificans
EDAT- 2014/01/28 06:00
MHDA- 2015/01/01 06:00
CRDT- 2014/01/28 06:00
PHST- 2013/06/19 00:00 [received]
PHST- 2013/09/04 00:00 [revised]
PHST- 2013/09/16 00:00 [accepted]
PHST- 2014/01/28 06:00 [entrez]
PHST- 2014/01/28 06:00 [pubmed]
PHST- 2015/01/01 06:00 [medline]
AID - S1341-321X(13)00036-6 [pii]
AID - 10.1016/j.jiac.2013.09.007 [doi]
PST - ppublish
SO  - J Infect Chemother. 2014 Mar;20(3):169-74. doi: 10.1016/j.jiac.2013.09.007. Epub 
      2013 Dec 11.