PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Improvement in toxicity in high risk prostate cancer patients treated with image-guided intensity-modulated radiotherapy compared to 3D conformal radiotherapy without daily image guidance.

Abstract Image-guided radiotherapy (IGRT) facilitates the delivery of a very precise radiation dose. In this study we compare the toxicity and biochemical progression-free survival between patients treated with daily image-guided intensity-modulated radiotherapy (IG-IMRT) and 3D conformal radiotherapy (3DCRT) without daily image guidance for high risk prostate cancer (PCa).
PMID
Related Publications

Involved-site image-guided intensity modulated versus 3D conformal radiation therapy in early stage supradiaphragmatic Hodgkin lymphoma.

Image-guided intensity-modulated radiotherapy of prostate cancer: Analysis of interfractional errors and acute toxicity.

Improved clinical outcomes with high-dose image guided radiotherapy compared with non-IGRT for the treatment of clinically localized prostate cancer.

Combination of dose escalation with technological advances (intensity-modulated and image-guided radiotherapy) is not associated with increased morbidity for patients with prostate cancer.

Acute toxicity after image-guided intensity modulated radiation therapy compared to 3D conformal radiation therapy in prostate cancer patients.

Authors

Mayor MeshTerms

Imaging, Three-Dimensional

Keywords
Journal Title radiation oncology (london, england)
Publication Year Start




 
PMID- 24495815
OWN - NLM
STAT- MEDLINE
DA  - 20140213
DCOM- 20141009
LR  - 20150515
IS  - 1748-717X (Electronic)
IS  - 1748-717X (Linking)
VI  - 9
DP  - 2014 Feb 04
TI  - Improvement in toxicity in high risk prostate cancer patients treated with
      image-guided intensity-modulated radiotherapy compared to 3D conformal
      radiotherapy without daily image guidance.
PG  - 44
LID - 10.1186/1748-717X-9-44 [doi]
AB  - BACKGROUND: Image-guided radiotherapy (IGRT) facilitates the delivery of a very
      precise radiation dose. In this study we compare the toxicity and biochemical
      progression-free survival between patients treated with daily image-guided
      intensity-modulated radiotherapy (IG-IMRT) and 3D conformal radiotherapy (3DCRT) 
      without daily image guidance for high risk prostate cancer (PCa). METHODS: A
      total of 503 high risk PCa patients treated with radiotherapy (RT) and endocrine 
      treatment between 2000 and 2010 were retrospectively reviewed. 115 patients were 
      treated with 3DCRT, and 388 patients were treated with IG-IMRT. 3DCRT patients
      were treated to 76 Gy and without daily image guidance and with 1-2 cm PTV
      margins. IG-IMRT patients were treated to 78 Gy based on daily image guidance of 
      fiducial markers, and the PTV margins were 5-7 mm. Furthermore, the dose-volume
      constraints to both the rectum and bladder were changed with the introduction of 
      IG-IMRT. RESULTS: The 2-year actuarial likelihood of developing grade > = 2 GI
      toxicity following RT was 57.3% in 3DCRT patients and 5.8% in IG-IMRT patients (p
      < 0.001). For GU toxicity the numbers were 41.8% and 29.7%, respectively (p =
      0.011). On multivariate analysis, 3DCRT was associated with a significantly
      increased risk of developing grade > = 2 GI toxicity compared to IG-IMRT (p <
      0.001, HR = 11.59 [CI: 6.67-20.14]). 3DCRT was also associated with an increased 
      risk of developing GU toxicity compared to IG-IMRT.The 3-year actuarial
      biochemical progression-free survival probability was 86.0% for 3DCRT and 90.3%
      for IG-IMRT (p = 0.386). On multivariate analysis there was no difference in
      biochemical progression-free survival between 3DCRT and IG-IMRT. CONCLUSION: The 
      difference in toxicity can be attributed to the combination of the IMRT technique
      with reduced dose to organs-at-risk, daily image guidance and margin reduction.
FAU - Sveistrup, Joen
AU  - Sveistrup J
AD  - Department of Radiation Oncology, Section 3994, Rigshospitalet, Blegdamsvej 9,
      Copenhagen 2100, Denmark. [email protected]
FAU - af Rosenschold, Per Munck
AU  - af Rosenschold PM
FAU - Deasy, Joseph O
AU  - Deasy JO
FAU - Oh, Jung Hun
AU  - Oh JH
FAU - Pommer, Tobias
AU  - Pommer T
FAU - Petersen, Peter Meidahl
AU  - Petersen PM
FAU - Engelholm, Svend Aage
AU  - Engelholm SA
LA  - eng
PT  - Comparative Study
PT  - Evaluation Studies
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140204
PL  - England
TA  - Radiat Oncol
JT  - Radiation oncology (London, England)
JID - 101265111
SB  - IM
MH  - Aged
MH  - Disease-Free Survival
MH  - Fiducial Markers
MH  - Humans
MH  - *Imaging, Three-Dimensional/methods
MH  - Male
MH  - Middle Aged
MH  - Organs at Risk
MH  - Prostatic Neoplasms/epidemiology/*radiotherapy
MH  - Radiation Injuries/epidemiology/*etiology
MH  - Radiotherapy Planning, Computer-Assisted/instrumentation/methods
MH  - Radiotherapy, Conformal/*adverse effects/instrumentation/methods
MH  - Radiotherapy, Image-Guided/*adverse effects/instrumentation/methods
MH  - Radiotherapy, Intensity-Modulated/*adverse effects/instrumentation/methods
MH  - Retrospective Studies
MH  - Risk Factors
PMC - PMC3922544
OID - NLM: PMC3922544
EDAT- 2014/02/06 06:00
MHDA- 2014/10/10 06:00
CRDT- 2014/02/06 06:00
PHST- 2013/10/07 [received]
PHST- 2014/01/29 [accepted]
AID - 1748-717X-9-44 [pii]
AID - 10.1186/1748-717X-9-44 [doi]
PST - epublish
SO  - Radiat Oncol. 2014 Feb 4;9:44. doi: 10.1186/1748-717X-9-44.