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%A Karlinski, Michal; Kobayashi, Adam; Czlonkowska, Anna; Mikulik, Robert; Vaclavik, Daniel; Brozman, Miroslav; Svigelj, Viktor; Csiba, Laszlo; Fekete, Klara; K?rv, Janika; Demarin, Vida; Vilionskis, Aleksandras; Jatuzis, Dalius; Krespi, Yakup; Ahmed, Niaz; Wahlgren, Nils
%A Safe Implementation of Treatments in Stroke?Eastern Europe (SITS-EAST) Investigators
%T Role of preexisting disability in patients treated with intravenous thrombolysis for ischemic stroke.
%J Stroke; a journal of cerebral circulation, vol. 45, no. 3, pp. 770-775
%D 03/2014
%V 45
%N 3
%M eng
%B Little is known about the effect of thrombolysis in patients with preexisting disability. Our aim was to evaluate the impact of different levels of prestroke disability on patients' profile and outcome after intravenous thrombolysis.
%K Aged, Aged, 80 and over, Brain Ischemia, Comorbidity, Confidence Intervals, Disability Evaluation, Disabled Persons, Endpoint Determination, Female, Humans, Logistic Models, Male, Middle Aged, Odds Ratio, Preexisting Condition Coverage, Prognosis, Registries, Stroke, Thrombolytic Therapy, Treatment Outcome
%P 770
%L 775
%Y 10.1161/STROKEAHA.113.003744
%W PHY
%G AUTHOR
%R 2014.......45..770K

@Article{Karlinski2014,
author="Karlinski, Michal
and Kobayashi, Adam
and Czlonkowska, Anna
and Mikulik, Robert
and Vaclavik, Daniel
and Brozman, Miroslav
and Svigelj, Viktor
and Csiba, Laszlo
and Fekete, Klara
and K{\~o}rv, Janika
and Demarin, Vida
and Vilionskis, Aleksandras
and Jatuzis, Dalius
and Krespi, Yakup
and Ahmed, Niaz
and Wahlgren, Nils
and {Safe Implementation of Treatments in Stroke--Eastern Europe (SITS-EAST) Investigators}",
title="Role of preexisting disability in patients treated with intravenous thrombolysis for ischemic stroke.",
journal="Stroke; a journal of cerebral circulation",
year="2014",
month="Mar",
day="04",
volume="45",
number="3",
pages="770--775",
keywords="Aged",
keywords="Aged, 80 and over",
keywords="Brain Ischemia",
keywords="Comorbidity",
keywords="Confidence Intervals",
keywords="Disability Evaluation",
keywords="Disabled Persons",
keywords="Endpoint Determination",
keywords="Female",
keywords="Humans",
keywords="Logistic Models",
keywords="Male",
keywords="Middle Aged",
keywords="Odds Ratio",
keywords="Preexisting Condition Coverage",
keywords="Prognosis",
keywords="Registries",
keywords="Stroke",
keywords="Thrombolytic Therapy",
keywords="Treatment Outcome",
abstract="Little is known about the effect of thrombolysis in patients with preexisting disability. Our aim was to evaluate the impact of different levels of prestroke disability on patients' profile and outcome after intravenous thrombolysis.",
issn="1524-4628",
doi="10.1161/STROKEAHA.113.003744",
url="http://www.ncbi.nlm.nih.gov/pubmed/24496395",
language="eng"
}

%0 Journal Article
%T Role of preexisting disability in patients treated with intravenous thrombolysis for ischemic stroke.
%A Karlinski, Michal
%A Kobayashi, Adam
%A Czlonkowska, Anna
%A Mikulik, Robert
%A Vaclavik, Daniel
%A Brozman, Miroslav
%A Svigelj, Viktor
%A Csiba, Laszlo
%A Fekete, Klara
%A K?rv, Janika
%A Demarin, Vida
%A Vilionskis, Aleksandras
%A Jatuzis, Dalius
%A Krespi, Yakup
%A Ahmed, Niaz
%A Wahlgren, Nils
%A Safe Implementation of Treatments in Stroke?Eastern Europe (SITS-EAST) Investigators
%J Stroke; a journal of cerebral circulation
%D 2014
%8 Mar 04
%V 45
%N 3
%@ 1524-4628
%G eng
%F Karlinski2014
%X Little is known about the effect of thrombolysis in patients with preexisting disability. Our aim was to evaluate the impact of different levels of prestroke disability on patients' profile and outcome after intravenous thrombolysis.
%K Aged
%K Aged, 80 and over
%K Brain Ischemia
%K Comorbidity
%K Confidence Intervals
%K Disability Evaluation
%K Disabled Persons
%K Endpoint Determination
%K Female
%K Humans
%K Logistic Models
%K Male
%K Middle Aged
%K Odds Ratio
%K Preexisting Condition Coverage
%K Prognosis
%K Registries
%K Stroke
%K Thrombolytic Therapy
%K Treatment Outcome
%U http://dx.doi.org/10.1161/STROKEAHA.113.003744
%U http://www.ncbi.nlm.nih.gov/pubmed/24496395
%P 770-775

PT Journal
AU Karlinski, M
   Kobayashi, A
   Czlonkowska, A
   Mikulik, R
   Vaclavik, D
   Brozman, M
   Svigelj, V
   Csiba, L
   Fekete, K
   K?rv, J
   Demarin, V
   Vilionskis, A
   Jatuzis, D
   Krespi, Y
   Ahmed, N
   Wahlgren, N
AU Safe Implementation of Treatments in Stroke?Eastern Europe (SITS-EAST) Investigators
TI Role of preexisting disability in patients treated with intravenous thrombolysis for ischemic stroke.
SO Stroke; a journal of cerebral circulation
JI Stroke
PD Mar
PY 2014
BP 770
EP 775
VL 45
IS 3
DI 10.1161/STROKEAHA.113.003744
LA eng
DE Aged; Aged, 80 and over; Brain Ischemia; Comorbidity; Confidence Intervals; Disability Evaluation; Disabled Persons; Endpoint Determination; Female; Humans; Logistic Models; Male; Middle Aged; Odds Ratio; Preexisting Condition Coverage; Prognosis; Registries; Stroke; Thrombolytic Therapy; Treatment Outcome
AB Little is known about the effect of thrombolysis in patients with preexisting disability. Our aim was to evaluate the impact of different levels of prestroke disability on patients' profile and outcome after intravenous thrombolysis.
ER

PMID- 24496395
OWN - NLM
STAT- MEDLINE
DA  - 20140225
DCOM- 20140422
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 45
IP  - 3
DP  - 2014 Mar
TI  - Role of preexisting disability in patients treated with intravenous thrombolysis 
      for ischemic stroke.
PG  - 770-5
LID - 10.1161/STROKEAHA.113.003744 [doi]
AB  - BACKGROUND AND PURPOSE: Little is known about the effect of thrombolysis in
      patients with preexisting disability. Our aim was to evaluate the impact of
      different levels of prestroke disability on patients' profile and outcome after
      intravenous thrombolysis. METHODS: We analyzed the data of all stroke patients
      admitted between October 2003 and December 2011 that were contributed to the Safe
      Implementation of Treatments in Stroke-Eastern Europe (SITS-EAST) registry.
      Patients with no prestroke disability at all (modified Rankin Scale [mRS] score, 
      0) were used as a reference in multivariable logistic regression. RESULTS: Of
      7250 patients, 5995 (82%) had prestroke mRS 0, 791 (11%) had prestroke mRS 1, 293
      (4%) had prestroke mRS 2, and 171 (2%) had prestroke mRS>/=3. Compared with
      patients with mRS 0, all other groups were older, had more comorbidities, and
      more severe neurological deficit on admission. There was no clear association
      between preexisting disability and the risk of symptomatic intracranial
      hemorrhage. Prestroke mRS 1, 2, and >/=3 were associated with increased risk of
      death at 3 months (odds ratio, 1.3, 2.0, and 2.6, respectively) and lower chance 
      of achieving favorable outcome (achieving mRS 0-2 or returning to the prestroke
      mRS; 0.80, 0.41, 0.59, respectively). Patients with mRS>/=3 and 2 had similar
      vascular profile and favorable outcome (34% versus 29%), despite higher mortality
      (48% versus 39%). CONCLUSIONS: Prestroke disability does not seem to
      independently increase the risk of symptomatic intracranial hemorrhage after
      thrombolysis. Despite higher mortality, 1 in 3 previously disabled patients may
      return to his/her prestroke mRS. Therefore, they should not be routinely excluded
      from thrombolytic therapy.
FAU - Karlinski, Michal
AU  - Karlinski M
AD  - From the Second Department of Neurology, Institute of Psychiatry and Neurology,
      Warsaw, Poland (M.K., A.K., A.C.); Interventional Stroke Treatment Centre,
      Institute of Psychiatry and Neurology, Warsaw, Poland (A.K.); Department of
      Experimental and Clinical Pharmacology, Medical University of Warsaw, Poland
      (A.C.); International Clinical Research Center, Neurology Department, St Anne's
      Hospital in Brno, Brno, Czech Republic (R.M., D.V.); Neurology Department,
      University Hospital Nitra, Constantin Philosopher University, Nitra, Slovakia
      (M.B.); Department of Vascular Neurology and Neurological Intensive Care,
      University Medical Centre Ljubljana and Zdravstveni Nasveti, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Hungary (L.C., K.F.); Department of Neurology and Neurosurgery,
      University of Tartu, Estonia (J.K.); Medical Center Aviva, Zagreb, Croatia
      (V.D.); Department of Neurology and Neurosurgery, Vilnius University and
      Republican Vilnius University Hospital, Lithuania (A.V.); Department of Neurology
      and Neurosurgery, Faculty of Medicine, Vilnius University and Vilnius University 
      Hospital Santariskiu Clinics, Lithuania (D.J.); Stroke Rehabilitation and
      Research Center, Memorial Sisli Hospital, Memorial Health Group Stroke Center,
      Istanbul, Turkey (Y.K.); and Department of Neurology, Karolinska University
      Hospital, Solna and Department of Clinical Neuroscience, Karolinska Institute,
      Stockholm, Sweden (N.A., N.W.).
FAU - Kobayashi, Adam
AU  - Kobayashi A
FAU - Czlonkowska, Anna
AU  - Czlonkowska A
FAU - Mikulik, Robert
AU  - Mikulik R
FAU - Vaclavik, Daniel
AU  - Vaclavik D
FAU - Brozman, Miroslav
AU  - Brozman M
FAU - Svigelj, Viktor
AU  - Svigelj V
FAU - Csiba, Laszlo
AU  - Csiba L
FAU - Fekete, Klara
AU  - Fekete K
FAU - Korv, Janika
AU  - Korv J
FAU - Demarin, Vida
AU  - Demarin V
FAU - Vilionskis, Aleksandras
AU  - Vilionskis A
FAU - Jatuzis, Dalius
AU  - Jatuzis D
FAU - Krespi, Yakup
AU  - Krespi Y
FAU - Ahmed, Niaz
AU  - Ahmed N
FAU - Wahlgren, Nils
AU  - Wahlgren N
CN  - Safe Implementation of Treatments in Stroke-Eastern Europe (SITS-EAST)
      Investigators
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20140204
PL  - United States
TA  - Stroke
JT  - Stroke; a journal of cerebral circulation
JID - 0235266
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Ischemia/*drug therapy/mortality
MH  - Comorbidity
MH  - Confidence Intervals
MH  - Disability Evaluation
MH  - *Disabled Persons
MH  - Endpoint Determination
MH  - Female
MH  - Humans
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Odds Ratio
MH  - *Preexisting Condition Coverage
MH  - Prognosis
MH  - Registries
MH  - Stroke/*drug therapy/mortality
MH  - Thrombolytic Therapy/*methods
MH  - Treatment Outcome
OTO - NOTNLM
OT  - comorbidity
OT  - stroke
OT  - thrombolytic therapy
OT  - treatment outcome
IR  - Mikulik R
FIR - Mikulik, Robert
IR  - Czlonkowska A
FIR - Czlonkowska, Anna
IR  - Brozman M
FIR - Brozman, Miroslav
IR  - Csiba L
FIR - Csiba, Laszlo
IR  - Korv J
FIR - Korv, Janika
IR  - Svigelj V
FIR - Svigelj, Viktor
IR  - Demarin V
FIR - Demarin, Vida
IR  - Jatuzis D
FIR - Jatuzis, Dalius
IR  - Vilionskis A
FIR - Vilionskis, Aleksandras
IR  - Krespi Y
FIR - Krespi, Yakup
IR  - Shamalov N
FIR - Shamalov, Nikolay
EDAT- 2014/02/06 06:00
MHDA- 2014/04/23 06:00
CRDT- 2014/02/06 06:00
PHST- 2014/02/04 [aheadofprint]
AID - STROKEAHA.113.003744 [pii]
AID - 10.1161/STROKEAHA.113.003744 [doi]
PST - ppublish
SO  - Stroke. 2014 Mar;45(3):770-5. doi: 10.1161/STROKEAHA.113.003744. Epub 2014 Feb 4.
TY  - JOUR
AU  - Karlinski, Michal
AU  - Kobayashi, Adam
AU  - Czlonkowska, Anna
AU  - Mikulik, Robert
AU  - Vaclavik, Daniel
AU  - Brozman, Miroslav
AU  - Svigelj, Viktor
AU  - Csiba, Laszlo
AU  - Fekete, Klara
AU  - K?rv, Janika
AU  - Demarin, Vida
AU  - Vilionskis, Aleksandras
AU  - Jatuzis, Dalius
AU  - Krespi, Yakup
AU  - Ahmed, Niaz
AU  - Wahlgren, Nils
AU  - Safe Implementation of Treatments in Stroke?Eastern Europe (SITS-EAST) Investigators
PY  - 2014/Mar/04
TI  - Role of preexisting disability in patients treated with intravenous thrombolysis for ischemic stroke.
T2  - Stroke
JO  - Stroke; a journal of cerebral circulation
SP  - 770
EP  - 775
VL  - 45
IS  - 3
KW  - Aged
KW  - Aged, 80 and over
KW  - Brain Ischemia
KW  - Comorbidity
KW  - Confidence Intervals
KW  - Disability Evaluation
KW  - Disabled Persons
KW  - Endpoint Determination
KW  - Female
KW  - Humans
KW  - Logistic Models
KW  - Male
KW  - Middle Aged
KW  - Odds Ratio
KW  - Preexisting Condition Coverage
KW  - Prognosis
KW  - Registries
KW  - Stroke
KW  - Thrombolytic Therapy
KW  - Treatment Outcome
N2  - Little is known about the effect of thrombolysis in patients with preexisting disability. Our aim was to evaluate the impact of different levels of prestroke disability on patients' profile and outcome after intravenous thrombolysis.
SN  - 1524-4628
UR  - http://dx.doi.org/10.1161/STROKEAHA.113.003744
UR  - http://www.ncbi.nlm.nih.gov/pubmed/24496395
ID  - Karlinski2014
ER  - 
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