PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Joint effects of known type 2 diabetes susceptibility loci in genome-wide association study of Singapore Chinese: the Singapore Chinese health study.

Abstract Genome-wide association studies (GWAS) have identified genetic factors in type 2 diabetes (T2D), mostly among individuals of European ancestry. We tested whether previously identified T2D-associated single nucleotide polymorphisms (SNPs) replicate and whether SNPs in regions near known T2D SNPs were associated with T2D within the Singapore Chinese Health Study.
PMID
Related Publications

Cross-sectional and longitudinal replication analyses of genome-wide association loci of type 2 diabetes in Han Chinese.

Use of net reclassification improvement (NRI) method confirms the utility of combined genetic risk score to predict type 2 diabetes.

Genetic variants on chromosome 6p21.1 and 6p22.3 are associated with type 2 diabetes risk: a case-control study in Han Chinese.

Polymorphisms identified through genome-wide association studies and their associations with type 2 diabetes in Chinese, Malays, and Asian-Indians in Singapore.

Identification of new genetic risk variants for type 2 diabetes.

Authors

Mayor MeshTerms

Genetic Predisposition to Disease

Genome-Wide Association Study

Keywords
Journal Title plos one
Publication Year Start




PMID- 24520337
OWN - NLM
STAT- MEDLINE
DA  - 20140212
DCOM- 20141013
LR  - 20150515
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 9
IP  - 2
DP  - 2014
TI  - Joint effects of known type 2 diabetes susceptibility loci in genome-wide
      association study of Singapore Chinese: the Singapore Chinese health study.
PG  - e87762
LID - 10.1371/journal.pone.0087762 [doi]
AB  - BACKGROUND: Genome-wide association studies (GWAS) have identified genetic
      factors in type 2 diabetes (T2D), mostly among individuals of European ancestry. 
      We tested whether previously identified T2D-associated single nucleotide
      polymorphisms (SNPs) replicate and whether SNPs in regions near known T2D SNPs
      were associated with T2D within the Singapore Chinese Health Study. METHODS: 2338
      cases and 2339 T2D controls from the Singapore Chinese Health Study were
      genotyped for 507,509 SNPs. Imputation extended the genotyped SNPs to 7,514,461
      with high estimated certainty (r(2)>0.8). Replication of known index SNP
      associations in T2D was attempted. Risk scores were computed as the sum of index 
      risk alleles. SNPs in regions +/- 100 kb around each index were tested for
      associations with T2D in conditional fine-mapping analysis. RESULTS: Of 69 index 
      SNPs, 20 were genotyped directly and genotypes at 35 others were well imputed.
      Among the 55 SNPs with data, disease associations were replicated (at p<0.05) for
      15 SNPs, while 32 more were directionally consistent with previous reports. Risk 
      score was a significant predictor with a 2.03 fold higher risk CI (1.69-2.44) of 
      T2D comparing the highest to lowest quintile of risk allele burden (p = 5.72 x
      10(-14)). Two improved SNPs around index rs10923931 and 5 new candidate SNPs
      around indices rs10965250 and rs1111875 passed simple Bonferroni corrections for 
      significance in conditional analysis. Nonetheless, only a small fraction (2.3% on
      the disease liability scale) of T2D burden in Singapore is explained by these
      SNPs. CONCLUSIONS: While diabetes risk in Singapore Chinese involves genetic
      variants, most disease risk remains unexplained. Further genetic work is ongoing 
      in the Singapore Chinese population to identify unique common variants not
      already seen in earlier studies. However rapid increases in T2D risk have
      occurred in recent decades in this population, indicating that dynamic
      environmental influences and possibly gene by environment interactions complicate
      the genetic architecture of this disease.
FAU - Chen, Zhanghua
AU  - Chen Z
AD  - Department of Preventive Medicine, University of Southern California, Los
      Angeles, California, United States of America.
FAU - Pereira, Mark A
AU  - Pereira MA
AD  - Division of Epidemiology and Community Health, University of Minnesota,
      Minneapolis, Minnesota, United States of America.
FAU - Seielstad, Mark
AU  - Seielstad M
AD  - Department of Laboratory Medicine, Department of Epidemiology and Biostatistics, 
      and California Institute for Quantitative Biosciences (QB3), University of
      California San Francisco, San Francisco, California, United States of America.
FAU - Koh, Woon-Puay
AU  - Koh WP
AD  - Duke-National University of Singapore Graduate Medical School, Singapore ; Saw
      Swee Hock School of Public Health, National University of Singapore, Singapore.
FAU - Tai, E Shyong
AU  - Tai ES
AD  - Duke-National University of Singapore Graduate Medical School, Singapore ; Saw
      Swee Hock School of Public Health, National University of Singapore, Singapore.
FAU - Teo, Yik-Ying
AU  - Teo YY
AD  - Saw Swee Hock School of Public Health, National University of Singapore,
      Singapore.
FAU - Liu, Jianjun
AU  - Liu J
AD  - Saw Swee Hock School of Public Health, National University of Singapore,
      Singapore ; Human Genetics, Genome Institute of Singapore, ASTAR, Singapore.
FAU - Hsu, Chris
AU  - Hsu C
AD  - Department of Preventive Medicine, University of Southern California, Los
      Angeles, California, United States of America.
FAU - Wang, Renwei
AU  - Wang R
AD  - Department of Epidemiology, University of Pittsburgh Cancer Institute,
      Pittsburgh, Pennsylvania, United States of America.
FAU - Odegaard, Andrew O
AU  - Odegaard AO
AD  - Division of Epidemiology and Community Health, University of Minnesota,
      Minneapolis, Minnesota, United States of America.
FAU - Thyagarajan, Bharat
AU  - Thyagarajan B
AD  - Division of Epidemiology and Community Health, University of Minnesota,
      Minneapolis, Minnesota, United States of America.
FAU - Koratkar, Revati
AU  - Koratkar R
AD  - Division of Epidemiology and Community Health, University of Minnesota,
      Minneapolis, Minnesota, United States of America.
FAU - Yuan, Jian-Min
AU  - Yuan JM
AD  - Department of Epidemiology, University of Pittsburgh Cancer Institute,
      Pittsburgh, Pennsylvania, United States of America.
FAU - Gross, Myron D
AU  - Gross MD
AD  - Division of Epidemiology and Community Health, University of Minnesota,
      Minneapolis, Minnesota, United States of America.
FAU - Stram, Daniel O
AU  - Stram DO
AD  - Department of Preventive Medicine, University of Southern California, Los
      Angeles, California, United States of America.
LA  - eng
GR  - R01 CA144034/CA/NCI NIH HHS/United States
GR  - R01 CA55069/CA/NCI NIH HHS/United States
GR  - R01 CA80205/CA/NCI NIH HHS/United States
GR  - R01 DK080720/DK/NIDDK NIH HHS/United States
GR  - R35 CA53890/CA/NCI NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
PT  - Research Support, Non-U.S. Gov't
DEP - 20140210
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
SB  - IM
MH  - Aged
MH  - Asian Continental Ancestry Group/*genetics
MH  - Case-Control Studies
MH  - Diabetes Mellitus, Type 2/*genetics
MH  - Female
MH  - Genetic Loci/*genetics
MH  - *Genetic Predisposition to Disease
MH  - *Genome-Wide Association Study
MH  - Health
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Polymorphism, Single Nucleotide
MH  - Singapore
PMC - PMC3919750
OID - NLM: PMC3919750
EDAT- 2014/02/13 06:00
MHDA- 2014/10/14 06:00
CRDT- 2014/02/13 06:00
PHST- 2014 [ecollection]
PHST- 2013/09/24 [received]
PHST- 2013/12/30 [accepted]
PHST- 2014/02/10 [epublish]
AID - 10.1371/journal.pone.0087762 [doi]
AID - PONE-D-13-39220 [pii]
PST - epublish
SO  - PLoS One. 2014 Feb 10;9(2):e87762. doi: 10.1371/journal.pone.0087762. eCollection
      2014.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>