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Cadmium in urothelial carcinoma of the bladder.

Abstract The aim of this study was to examine the relationship between cadmium (Cd) and bladder cancer (urothelial carcinoma of the bladder). Cadmium concentrations in two 36-sample series of bladder cancer tissue and blood, from patients with the neoplasm, were matched with those of the control group. The amount of heavy metal in every tissue sample was determined using atomic absorption spectrometry. This was correlated with tumour stage. While the median cadmium concentration levels reached statistically lower values in the bladder cancer tissue, as compared with the non-cancer one (11.695 ng/g and 56.32 ng/g respectively, p < 0.001), the median Cd levels in the blood of the patients with this carcinoma showed no statistical difference when compared to those of the control group (8.237 μg/l and 7.556 μg/l respectively, p = 0.121). The median levels of cadmium in the bladder tissue, depending on the stage of the tumour, compared with the tissue without the neoplasm, observed the same relationship for both non-muscle invasive and muscle-invasive tumours (p < 0.002 and p < 0.02 respectively). This study has shown that patients with urothelial carcinoma of the bladder had lower tissue cadmium levels than people without tumour while no difference in the Cd blood levels between the two groups of patients under investigation was found.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title polish journal of pathology : official journal of the polish society of pathologists
Publication Year Start




PMID- 25119010
OWN - NLM
STAT- MEDLINE
DCOM- 20140923
LR  - 20140814
IS  - 1233-9687 (Print)
IS  - 1233-9687 (Linking)
VI  - 65
IP  - 1
DP  - 2014 Mar
TI  - Cadmium in urothelial carcinoma of the bladder.
PG  - 55-9
AB  - The aim of this study was to examine the relationship between cadmium (Cd) and
      bladder cancer (urothelial carcinoma of the bladder). Cadmium concentrations in
      two 36-sample series of bladder cancer tissue and blood, from patients with the
      neoplasm, were matched with those of the control group. The amount of heavy metal
      in every tissue sample was determined using atomic absorption spectrometry. This 
      was correlated with tumour stage. While the median cadmium concentration levels
      reached statistically lower values in the bladder cancer tissue, as compared with
      the non-cancer one (11.695 ng/g and 56.32 ng/g respectively, p &lt; 0.001), the
      median Cd levels in the blood of the patients with this carcinoma showed no
      statistical difference when compared to those of the control group (8.237 mug/l
      and 7.556 mug/l respectively, p = 0.121). The median levels of cadmium in the
      bladder tissue, depending on the stage of the tumour, compared with the tissue
      without the neoplasm, observed the same relationship for both non-muscle invasive
      and muscle-invasive tumours (p &lt; 0.002 and p &lt; 0.02 respectively). This study has
      shown that patients with urothelial carcinoma of the bladder had lower tissue
      cadmium levels than people without tumour while no difference in the Cd blood
      levels between the two groups of patients under investigation was found.
FAU - Golabek, Tomasz
AU  - Golabek T
AD  - Tomasz Golabek Department of Urology Collegium Medicum of the Jagiellonian
      University Kracow, Poland e-mail: [email protected]
FAU - Darewicz, Barbara
AU  - Darewicz B
FAU - Kudelski, Jacek
AU  - Kudelski J
FAU - Socha, Katarzyna
AU  - Socha K
FAU - Markiewicz-Zukowska, Renata
AU  - Markiewicz-Zukowska R
FAU - Chlosta, Piotr
AU  - Chlosta P
FAU - Okon, Krzysztof
AU  - Okon K
FAU - Borawska, Maria
AU  - Borawska M
LA  - eng
PT  - Journal Article
PL  - Poland
TA  - Pol J Pathol
JT  - Polish journal of pathology : official journal of the Polish Society of
      Pathologists
JID - 9437432
RN  - 00BH33GNGH (Cadmium)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Cadmium/*metabolism
MH  - Carcinoma, Transitional Cell/*metabolism/*pathology
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Staging
MH  - Urinary Bladder Neoplasms/*metabolism/*pathology
MH  - Urothelium/metabolism/pathology
EDAT- 2014/08/15 06:00
MHDA- 2014/09/24 06:00
CRDT- 2014/08/15 06:00
PHST- 2014/08/15 06:00 [entrez]
PHST- 2014/08/15 06:00 [pubmed]
PHST- 2014/09/24 06:00 [medline]
AID - 22728 [pii]
PST - ppublish
SO  - Pol J Pathol. 2014 Mar;65(1):55-9.