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Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome.

Abstract Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome.
PMID
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Authors

Mayor MeshTerms
Keywords

Anti-La;

Anti-Ro;

Anti-salivary gland protein 1 (SP1)

Rheumatoid arthritis;

Sjogren's syndrome;

Journal Title clinical immunology (orlando, fla.)
Publication Year Start
%A Shen, Long; Kapsogeorgou, Efstathia K.; Yu, Meixing; Suresh, Lakshmanan; Malyavantham, Kishore; Tzioufas, Anthanasios G.; Ambrus, Julian L.
%T Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome.
%J Clinical immunology (Orlando, Fla.), vol. 155, no. 1, pp. 42-46
%D 11/2014
%V 155
%N 1
%M eng
%B Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome.
%K Adult, Aged, Aged, 80 and over, Arthritis, Rheumatoid, Autoantibodies, Case-Control Studies, Enzyme-Linked Immunosorbent Assay, Female, Gene Expression Regulation, Humans, Male, Middle Aged, Salivary Proteins and Peptides, Sjogren's Syndrome, Young Adult
%P 42
%L 46
%Y 10.1016/j.clim.2014.08.009
%W PHY
%G AUTHOR
%R 2014......155...42S

@Article{Shen2014,
author="Shen, Long
and Kapsogeorgou, Efstathia K.
and Yu, Meixing
and Suresh, Lakshmanan
and Malyavantham, Kishore
and Tzioufas, Anthanasios G.
and Ambrus, Julian L.",
title="Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome.",
journal="Clinical immunology (Orlando, Fla.)",
year="2014",
month="Nov",
day="30",
volume="155",
number="1",
pages="42--46",
keywords="Adult",
keywords="Aged",
keywords="Aged, 80 and over",
keywords="Arthritis, Rheumatoid",
keywords="Autoantibodies",
keywords="Case-Control Studies",
keywords="Enzyme-Linked Immunosorbent Assay",
keywords="Female",
keywords="Gene Expression Regulation",
keywords="Humans",
keywords="Male",
keywords="Middle Aged",
keywords="Salivary Proteins and Peptides",
keywords="Sjogren's Syndrome",
keywords="Young Adult",
abstract="Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52\% of SS patients while anti-Ro/anti-La was present in 63\% of patients. 19\% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50\% had antibodies anti-SP1 while 40\% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome.",
issn="1521-7035",
doi="10.1016/j.clim.2014.08.009",
url="http://www.ncbi.nlm.nih.gov/pubmed/25178982",
language="eng"
}

%0 Journal Article
%T Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome.
%A Shen, Long
%A Kapsogeorgou, Efstathia K.
%A Yu, Meixing
%A Suresh, Lakshmanan
%A Malyavantham, Kishore
%A Tzioufas, Anthanasios G.
%A Ambrus, Julian L.
%J Clinical immunology (Orlando, Fla.)
%D 2014
%8 Nov 30
%V 155
%N 1
%@ 1521-7035
%G eng
%F Shen2014
%X Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome.
%K Adult
%K Aged
%K Aged, 80 and over
%K Arthritis, Rheumatoid
%K Autoantibodies
%K Case-Control Studies
%K Enzyme-Linked Immunosorbent Assay
%K Female
%K Gene Expression Regulation
%K Humans
%K Male
%K Middle Aged
%K Salivary Proteins and Peptides
%K Sjogren's Syndrome
%K Young Adult
%U http://dx.doi.org/10.1016/j.clim.2014.08.009
%U http://www.ncbi.nlm.nih.gov/pubmed/25178982
%P 42-46

PT Journal
AU Shen, L
   Kapsogeorgou, EK
   Yu, M
   Suresh, L
   Malyavantham, K
   Tzioufas, AG
   Ambrus, JL
TI Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome.
SO Clinical immunology (Orlando, Fla.)
JI Clin. Immunol.
PD Nov
PY 2014
BP 42
EP 46
VL 155
IS 1
DI 10.1016/j.clim.2014.08.009
LA eng
DE Adult; Aged; Aged, 80 and over; Arthritis, Rheumatoid; Autoantibodies; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Gene Expression Regulation; Humans; Male; Middle Aged; Salivary Proteins and Peptides; Sjogren's Syndrome; Young Adult
AB Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome.
ER

PMID- 25178982
OWN - NLM
STAT- MEDLINE
DA  - 20141202
DCOM- 20150126
IS  - 1521-7035 (Electronic)
IS  - 1521-6616 (Linking)
VI  - 155
IP  - 1
DP  - 2014 Nov
TI  - Evaluation of salivary gland protein 1 antibodies in patients with primary and
      secondary Sjogren's syndrome.
PG  - 42-6
LID - 10.1016/j.clim.2014.08.009 [doi]
LID - S1521-6616(14)00200-9 [pii]
AB  - Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and
      anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently 
      been identified in patients with SS. The current work involved a cross sectional 
      study to determine whether anti-SP1 antibodies were identified in particular
      subgroups of patients with SS. The results of this study revealed that anti-SP1
      antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La
      was present in 63% of patients. 19% of patients had anti-SP1 without
      anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and
      anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while
      40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in 
      both primary and secondary SS and rarely in normal controls. Future studies are
      needed to determine the roles and timing of expression of anti-SP1 antibodies in 
      Sjogren's syndrome.
CI  - Copyright (c) 2014 Elsevier Inc. All rights reserved.
FAU - Shen, Long
AU  - Shen L
AD  - Division of Allergy, Immunology and Rheumatology, Department of Medicine, School 
      of Medicine and Biomedical Sciences, State University of New York at Buffalo,
      Buffalo, NY 14203, USA.
FAU - Kapsogeorgou, Efstathia K
AU  - Kapsogeorgou EK
AD  - Department of Pathophysiology, National University of Athens, Athens, Greece.
FAU - Yu, Meixing
AU  - Yu M
AD  - Division of Allergy, Immunology and Rheumatology, Department of Medicine, School 
      of Medicine and Biomedical Sciences, State University of New York at Buffalo,
      Buffalo, NY 14203, USA.
FAU - Suresh, Lakshmanan
AU  - Suresh L
AD  - IMMCO Diagnostics Inc., Buffalo, NY 14228, USA.
FAU - Malyavantham, Kishore
AU  - Malyavantham K
AD  - IMMCO Diagnostics Inc., Buffalo, NY 14228, USA.
FAU - Tzioufas, Anthanasios G
AU  - Tzioufas AG
AD  - Department of Pathophysiology, National University of Athens, Athens, Greece.
FAU - Ambrus, Julian L Jr
AU  - Ambrus JL Jr
AD  - Division of Allergy, Immunology and Rheumatology, Department of Medicine, School 
      of Medicine and Biomedical Sciences, State University of New York at Buffalo,
      Buffalo, NY 14203, USA. Electronic address: [email protected]
LA  - eng
PT  - Journal Article
DEP - 20140830
PL  - United States
TA  - Clin Immunol
JT  - Clinical immunology (Orlando, Fla.)
JID - 100883537
RN  - 0 (Autoantibodies)
RN  - 0 (Salivary Proteins and Peptides)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Arthritis, Rheumatoid/immunology
MH  - Autoantibodies
MH  - Case-Control Studies
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Gene Expression Regulation/immunology
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Salivary Proteins and Peptides/*immunology
MH  - Sjogren's Syndrome/*immunology/metabolism
MH  - Young Adult
OTO - NOTNLM
OT  - Anti-La;
OT  - Anti-Ro;
OT  - Anti-salivary gland protein 1 (SP1)
OT  - Rheumatoid arthritis;
OT  - Sjogren's syndrome;
EDAT- 2014/09/03 06:00
MHDA- 2015/01/27 06:00
CRDT- 2014/09/03 06:00
PHST- 2014/07/09 [received]
PHST- 2014/08/22 [revised]
PHST- 2014/08/23 [accepted]
PHST- 2014/08/30 [aheadofprint]
AID - S1521-6616(14)00200-9 [pii]
AID - 10.1016/j.clim.2014.08.009 [doi]
PST - ppublish
SO  - Clin Immunol. 2014 Nov;155(1):42-6. doi: 10.1016/j.clim.2014.08.009. Epub 2014
      Aug 30.
TY  - JOUR
AU  - Shen, Long
AU  - Kapsogeorgou, Efstathia K.
AU  - Yu, Meixing
AU  - Suresh, Lakshmanan
AU  - Malyavantham, Kishore
AU  - Tzioufas, Anthanasios G.
AU  - Ambrus, Julian L.
PY  - 2014/Nov/30
TI  - Evaluation of salivary gland protein 1 antibodies in patients with primary and secondary Sjogren's syndrome.
T2  - Clin. Immunol.
JO  - Clinical immunology (Orlando, Fla.)
SP  - 42
EP  - 46
VL  - 155
IS  - 1
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Arthritis, Rheumatoid
KW  - Autoantibodies
KW  - Case-Control Studies
KW  - Enzyme-Linked Immunosorbent Assay
KW  - Female
KW  - Gene Expression Regulation
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Salivary Proteins and Peptides
KW  - Sjogren's Syndrome
KW  - Young Adult
N2  - Sjogren's syndrome (SS) has been associated with the expression of anti-Ro and anti-La antibodies. Anti-salivary gland protein 1 (SP1) antibodies have recently been identified in patients with SS. The current work involved a cross sectional study to determine whether anti-SP1 antibodies were identified in particular subgroups of patients with SS. The results of this study revealed that anti-SP1 antibodies were present in the sera of 52% of SS patients while anti-Ro/anti-La was present in 63% of patients. 19% of patients had anti-SP1 without anti-Ro/anti-La. Patients with SS and lymphoma expressed anti-Ro, anti-La and anti-SP1 together. In SS associated with RA, 50% had antibodies anti-SP1 while 40% had anti-Ro/anti-La. In conclusion, anti-SP1 antibodies are commonly seen in both primary and secondary SS and rarely in normal controls. Future studies are needed to determine the roles and timing of expression of anti-SP1 antibodies in Sjogren's syndrome.
SN  - 1521-7035
UR  - http://dx.doi.org/10.1016/j.clim.2014.08.009
UR  - http://www.ncbi.nlm.nih.gov/pubmed/25178982
ID  - Shen2014
ER  - 
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