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Transcatheter aortic valve implantation combined with elective coronary artery stenting: a simultaneous approach?.

Abstract Many patients referred for transcatheter aortic valve implantation (TAVI) also require percutaneous coronary intervention (PCI). The aim of the study was to identify whether combined treatment of patients with aortic stenosis and coronary artery disease (CAD) with TAVI and PCI has comparable results to treatment of patients with no CAD or with CAD with non-significant lesions who receive only TAVI.
PMID
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Authors

Mayor MeshTerms
Keywords

Aortic valve stenosis

Coronary artery disease

Percutaneous coronary intervention

Transcatheter aortic valve implantation

Journal Title european journal of cardio-thoracic surgery : official journal of the european association for cardio-thoracic surgery
Publication Year Start
%A Penkalla, Adam; Pasic, Miralem; Drews, Thorsten; Buz, Semih; Dreysse, Stephan; Kukucka, Marian; Mladenow, Alexander; Hetzer, Roland; Unbehaun, Axel
%T Transcatheter aortic valve implantation combined with elective coronary artery stenting: a simultaneous approach?.
%J European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery, vol. 47, no. 6, pp. 1083-1089
%D 06/2015
%V 47
%N 6
%M eng
%B Many patients referred for transcatheter aortic valve implantation (TAVI) also require percutaneous coronary intervention (PCI). The aim of the study was to identify whether combined treatment of patients with aortic stenosis and coronary artery disease (CAD) with TAVI and PCI has comparable results to treatment of patients with no CAD or with CAD with non-significant lesions who receive only TAVI.
%K Aged, Aged, 80 and over, Aortic Valve Stenosis, Coronary Artery Disease, Coronary Vessels, Female, Humans, Kaplan-Meier Estimate, Male, Percutaneous Coronary Intervention, Retrospective Studies, Stents, Transcatheter Aortic Valve Replacement
%P 1083
%L 1089
%Y 10.1093/ejcts/ezu339
%W PHY
%G AUTHOR
%R 2015.......47.1083P

@Article{Penkalla2015,
author="Penkalla, Adam
and Pasic, Miralem
and Drews, Thorsten
and Buz, Semih
and Dreysse, Stephan
and Kukucka, Marian
and Mladenow, Alexander
and Hetzer, Roland
and Unbehaun, Axel",
title="Transcatheter aortic valve implantation combined with elective coronary artery stenting: a simultaneous approach{\textdagger}.",
journal="European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery",
year="2015",
month="Jun",
day="12",
volume="47",
number="6",
pages="1083--1089",
keywords="Aged",
keywords="Aged, 80 and over",
keywords="Aortic Valve Stenosis",
keywords="Coronary Artery Disease",
keywords="Coronary Vessels",
keywords="Female",
keywords="Humans",
keywords="Kaplan-Meier Estimate",
keywords="Male",
keywords="Percutaneous Coronary Intervention",
keywords="Retrospective Studies",
keywords="Stents",
keywords="Transcatheter Aortic Valve Replacement",
abstract="Many patients referred for transcatheter aortic valve implantation (TAVI) also require percutaneous coronary intervention (PCI). The aim of the study was to identify whether combined treatment of patients with aortic stenosis and coronary artery disease (CAD) with TAVI and PCI has comparable results to treatment of patients with no CAD or with CAD with non-significant lesions who receive only TAVI.",
issn="1873-734X",
doi="10.1093/ejcts/ezu339",
url="http://www.ncbi.nlm.nih.gov/pubmed/25217500",
language="eng"
}

%0 Journal Article
%T Transcatheter aortic valve implantation combined with elective coronary artery stenting: a simultaneous approach?.
%A Penkalla, Adam
%A Pasic, Miralem
%A Drews, Thorsten
%A Buz, Semih
%A Dreysse, Stephan
%A Kukucka, Marian
%A Mladenow, Alexander
%A Hetzer, Roland
%A Unbehaun, Axel
%J European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
%D 2015
%8 Jun 12
%V 47
%N 6
%@ 1873-734X
%G eng
%F Penkalla2015
%X Many patients referred for transcatheter aortic valve implantation (TAVI) also require percutaneous coronary intervention (PCI). The aim of the study was to identify whether combined treatment of patients with aortic stenosis and coronary artery disease (CAD) with TAVI and PCI has comparable results to treatment of patients with no CAD or with CAD with non-significant lesions who receive only TAVI.
%K Aged
%K Aged, 80 and over
%K Aortic Valve Stenosis
%K Coronary Artery Disease
%K Coronary Vessels
%K Female
%K Humans
%K Kaplan-Meier Estimate
%K Male
%K Percutaneous Coronary Intervention
%K Retrospective Studies
%K Stents
%K Transcatheter Aortic Valve Replacement
%U http://dx.doi.org/10.1093/ejcts/ezu339
%U http://www.ncbi.nlm.nih.gov/pubmed/25217500
%P 1083-1089

PT Journal
AU Penkalla, A
   Pasic, M
   Drews, T
   Buz, S
   Dreysse, S
   Kukucka, M
   Mladenow, A
   Hetzer, R
   Unbehaun, A
TI Transcatheter aortic valve implantation combined with elective coronary artery stenting: a simultaneous approach?.
SO European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
JI Eur J Cardiothorac Surg
PD Jun
PY 2015
BP 1083
EP 1089
VL 47
IS 6
DI 10.1093/ejcts/ezu339
LA eng
DE Aged; Aged, 80 and over; Aortic Valve Stenosis; Coronary Artery Disease; Coronary Vessels; Female; Humans; Kaplan-Meier Estimate; Male; Percutaneous Coronary Intervention; Retrospective Studies; Stents; Transcatheter Aortic Valve Replacement
AB Many patients referred for transcatheter aortic valve implantation (TAVI) also require percutaneous coronary intervention (PCI). The aim of the study was to identify whether combined treatment of patients with aortic stenosis and coronary artery disease (CAD) with TAVI and PCI has comparable results to treatment of patients with no CAD or with CAD with non-significant lesions who receive only TAVI.
ER

PMID- 25217500
OWN - NLM
STAT- MEDLINE
DA  - 20150520
DCOM- 20160303
IS  - 1873-734X (Electronic)
IS  - 1010-7940 (Linking)
VI  - 47
IP  - 6
DP  - 2015 Jun
TI  - Transcatheter aortic valve implantation combined with elective coronary artery
      stenting: a simultaneous approachdagger.
PG  - 1083-9
LID - 10.1093/ejcts/ezu339 [doi]
AB  - OBJECTIVES: Many patients referred for transcatheter aortic valve implantation
      (TAVI) also require percutaneous coronary intervention (PCI). The aim of the
      study was to identify whether combined treatment of patients with aortic stenosis
      and coronary artery disease (CAD) with TAVI and PCI has comparable results to
      treatment of patients with no CAD or with CAD with non-significant lesions who
      receive only TAVI. METHODS: Between April 2008 and August 2013, 730 consecutive
      patients underwent transapical TAVI at our institution. In our study population
      of 593 patients, 285 (48.1%) had no CAD and received TAVI only (Group I); 232
      (39.1%) presented with CAD but no highly significant coronary artery lesion(s)
      and also received TAVI only (Group II), and 76 (12.8%) had CAD and highly
      significant coronary lesion(s) and underwent combined, single-staged TAVI and PCI
      (Group III). Three transapical TAVI patients who received PCI because of
      iatrogenic coronary artery obstruction during TAVI and 134 transapical TAVI
      patients with previous CABG were excluded from this study. RESULTS: Group II
      showed a calculated mean SYNTAX score of 5.7 +/- 7.4. However, Group III showed a
      statistically significantly higher mean SYNTAX score of 8.0 +/- 5.7 than Group II
      (P < 0.001) before the combined procedure. Combined TAVI and PCI reduced the mean
      SYNTAX score significantly from 8.0 +/- 5.7 to 3.0 +/- 4.9 (P < 0.001) in those
      patients presenting with severe aortic stenosis and highly significant CAD (Group
      III). The thirty-day all-cause mortality rate was 5.3, 3.9 and 2.6% for Group I, 
      II and III, respectively (P = 0.609). Patients with highly significant CAD
      undergoing TAVI and PCI had similar survival up to 3 years as patients without
      CAD undergoing TAVI only. Radiation time and amount of contrast agent were higher
      during combined treatment in Group III (P < 0.05). However, no difference in
      acute kidney injury post-procedurally was observed. CONCLUSIONS: Single-stage
      combined treatment of severe aortic stenosis and highly relevant coronary lesions
      is a safe and feasible procedure. Early survival and survival up to 3 years are
      comparable to that observed in patients presenting without CAD who received TAVI 
      only. PCI effectively reduces the complexity of coronary lesions. Although more
      contrast agent is applied during the combined treatment, the rate of acute kidney
      injury was not higher.
CI  - (c) The Author 2014. Published by Oxford University Press on behalf of the
      European Association for Cardio-Thoracic Surgery. All rights reserved.
FAU - Penkalla, Adam
AU  - Penkalla A
AD  - Deutsches Herzzentrum Berlin, Berlin, Germany.
FAU - Pasic, Miralem
AU  - Pasic M
AD  - Deutsches Herzzentrum Berlin, Berlin, Germany [email protected]
FAU - Drews, Thorsten
AU  - Drews T
AD  - Deutsches Herzzentrum Berlin, Berlin, Germany.
FAU - Buz, Semih
AU  - Buz S
AD  - Deutsches Herzzentrum Berlin, Berlin, Germany.
FAU - Dreysse, Stephan
AU  - Dreysse S
AD  - Deutsches Herzzentrum Berlin, Berlin, Germany.
FAU - Kukucka, Marian
AU  - Kukucka M
AD  - Deutsches Herzzentrum Berlin, Berlin, Germany.
FAU - Mladenow, Alexander
AU  - Mladenow A
AD  - Deutsches Herzzentrum Berlin, Berlin, Germany.
FAU - Hetzer, Roland
AU  - Hetzer R
AD  - Deutsches Herzzentrum Berlin, Berlin, Germany.
FAU - Unbehaun, Axel
AU  - Unbehaun A
AD  - Deutsches Herzzentrum Berlin, Berlin, Germany.
LA  - eng
PT  - Journal Article
DEP - 20140912
PL  - Germany
TA  - Eur J Cardiothorac Surg
JT  - European journal of cardio-thoracic surgery : official journal of the European
      Association for Cardio-thoracic Surgery
JID - 8804069
SB  - IM
MH  - Aged
MH  - Aged, 80 and over
MH  - Aortic Valve Stenosis/surgery
MH  - Coronary Artery Disease/surgery
MH  - Coronary Vessels/*surgery
MH  - Female
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Percutaneous Coronary Intervention/adverse effects/*methods/mortality
MH  - Retrospective Studies
MH  - Stents
MH  - Transcatheter Aortic Valve Replacement/adverse effects/*methods/mortality
OTO - NOTNLM
OT  - Aortic valve stenosis
OT  - Coronary artery disease
OT  - Percutaneous coronary intervention
OT  - Transcatheter aortic valve implantation
EDAT- 2014/09/14 06:00
MHDA- 2016/03/05 06:00
CRDT- 2014/09/14 06:00
PHST- 2013/12/16 [received]
PHST- 2014/08/01 [accepted]
PHST- 2014/09/12 [aheadofprint]
AID - ezu339 [pii]
AID - 10.1093/ejcts/ezu339 [doi]
PST - ppublish
SO  - Eur J Cardiothorac Surg. 2015 Jun;47(6):1083-9. doi: 10.1093/ejcts/ezu339. Epub
      2014 Sep 12.
TY  - JOUR
AU  - Penkalla, Adam
AU  - Pasic, Miralem
AU  - Drews, Thorsten
AU  - Buz, Semih
AU  - Dreysse, Stephan
AU  - Kukucka, Marian
AU  - Mladenow, Alexander
AU  - Hetzer, Roland
AU  - Unbehaun, Axel
PY  - 2015/Jun/12
TI  - Transcatheter aortic valve implantation combined with elective coronary artery stenting: a simultaneous approach?.
T2  - Eur J Cardiothorac Surg
JO  - European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
SP  - 1083
EP  - 1089
VL  - 47
IS  - 6
KW  - Aged
KW  - Aged, 80 and over
KW  - Aortic Valve Stenosis
KW  - Coronary Artery Disease
KW  - Coronary Vessels
KW  - Female
KW  - Humans
KW  - Kaplan-Meier Estimate
KW  - Male
KW  - Percutaneous Coronary Intervention
KW  - Retrospective Studies
KW  - Stents
KW  - Transcatheter Aortic Valve Replacement
N2  - Many patients referred for transcatheter aortic valve implantation (TAVI) also require percutaneous coronary intervention (PCI). The aim of the study was to identify whether combined treatment of patients with aortic stenosis and coronary artery disease (CAD) with TAVI and PCI has comparable results to treatment of patients with no CAD or with CAD with non-significant lesions who receive only TAVI.
SN  - 1873-734X
UR  - http://dx.doi.org/10.1093/ejcts/ezu339
UR  - http://www.ncbi.nlm.nih.gov/pubmed/25217500
ID  - Penkalla2015
ER  - 
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