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PMID- 25455533
OWN - NLM
STAT- MEDLINE
DCOM- 20150414
LR  - 20150101
IS  - 1556-5653 (Electronic)
IS  - 0015-0282 (Linking)
VI  - 103
IP  - 1
DP  - 2015 Jan
TI  - Long-term results of vaginal construction with the use of Frank dilation and a
      peritoneal graft (Davydov procedure) in patients with Mayer-Rokitansky-Kuster
      syndrome.
PG  - 220-7.e1
LID - 10.1016/j.fertnstert.2014.10.014 [doi]
LID - S0015-0282(14)02264-X [pii]
AB  - OBJECTIVE: To describe long-term outcomes after nonsurgical and surgical
      treatment of vaginal agenesis in a cohort of girls and women with
      Mayer-Rokitansky-Kuster (MRK) syndrome. DESIGN: Retrospective cohort study using 
      a standardized case record form. SETTING: University hospital. PATIENT(S): All
      girls and women with vaginal agenesis due to MRK syndrome, presenting during a
      40-year period (1962-2012). INTERVENTION(S): Frank dilation and surgical
      treatment (with the use of a peritoneal graft, i.e., the Davydov method) for
      vaginal agenesis. MAIN OUTCOME MEASURE(S): Functional vaginal depth and
      complications. RESULT(S): Two hundred fifty-four women with MRK visited the
      department. Urinary tract anomalies were found in 72 patients (31%), and other
      congenital anomalies in 59 (32%) of the patients with available data. One hundred
      sixty women were treated for vaginal agenesis. The mean follow-up time was 90
      months (range 0-560 months). Sixty-eight patients had surgical treatment for
      vaginal agenesis with the use of a peritoneal graft (Davydov method) and reached 
      a functional depth of the vagina of 7.8 cm (range 1-13 cm) Surgical therapy
      preceded by nonsurgical Frank dilation and/or attempted sexual intercourse did
      not result in more functional depth of the neovagina. The formation of
      granulation tissue (23%) and the tendency to obliterate (12%) were the major
      problems when using a peritoneal graft. CONCLUSION(S): Long-term results of both 
      Frank dilation and Davydov neovagina procedure in experienced hands were good.
      The use of a peritoneal graft may be regarded as a good alternative to other
      widely used neovagina techniques using a graft, such as split-thickness skin
      graft or sigmoid neovagina.
CI  - Copyright (c) 2015 American Society for Reproductive Medicine. Published by
      Elsevier Inc. All rights reserved.
FAU - Willemsen, Wim N P
AU  - Willemsen WN
AD  - Department of Obstetrics and Gynecology, Radboud University Medical Center,
      Nijmegen, the Netherlands. Electronic address: wimwi[email protected]
FAU - Kluivers, Kirsten B
AU  - Kluivers KB
AD  - Department of Obstetrics and Gynecology, Radboud University Medical Center,
      Nijmegen, the Netherlands.
LA  - eng
PT  - Journal Article
DEP - 20141115
PL  - United States
TA  - Fertil Steril
JT  - Fertility and sterility
JID - 0372772
RN  - Mullerian aplasia
SB  - IM
MH  - 46, XX Disorders of Sex Development/*diagnosis/*therapy
MH  - Adolescent
MH  - Adult
MH  - Child
MH  - Child, Preschool
MH  - Cohort Studies
MH  - Combined Modality Therapy/methods
MH  - Congenital Abnormalities/*diagnosis/*therapy
MH  - Dilatation/*methods
MH  - Female
MH  - Graft Rejection/etiology/prevention & control
MH  - Humans
MH  - Longitudinal Studies
MH  - Mullerian Ducts/*abnormalities
MH  - Peritoneum/*transplantation
MH  - Reconstructive Surgical Procedures/adverse effects/*methods
MH  - Retrospective Studies
MH  - Treatment Outcome
MH  - Vagina/*surgery
MH  - Young Adult
OTO - NOTNLM
OT  - Davydov
OT  - Frank nonsurgical method
OT  - Mayer-Rokitansky-Kuster
OT  - neovaginoplasty
OT  - peritoneal graft
EDAT- 2014/12/03 06:00
MHDA- 2015/04/15 06:00
CRDT- 2014/12/03 06:00
PHST- 2014/05/07 00:00 [received]
PHST- 2014/10/09 00:00 [revised]
PHST- 2014/10/09 00:00 [accepted]
PHST- 2014/12/03 06:00 [entrez]
PHST- 2014/12/03 06:00 [pubmed]
PHST- 2015/04/15 06:00 [medline]
AID - S0015-0282(14)02264-X [pii]
AID - 10.1016/j.fertnstert.2014.10.014 [doi]
PST - ppublish
SO  - Fertil Steril. 2015 Jan;103(1):220-7.e1. doi: 10.1016/j.fertnstert.2014.10.014.
      Epub 2014 Nov 15.