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Comparative effectiveness of standard care with IV thrombolysis versus without IV thrombolysis for mild ischemic stroke.

Abstract One third of patients presenting with initially mild strokes have unfavorable outcomes, and the efficacy of intravenous thrombolysis (IVT) in this population has not been proven. This study aimed to evaluate the comparative effectiveness of standard care with IVT versus without IVT in mild stroke patients.
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Keywords
Journal Title journal of the american heart association
Publication Year Start
%A Choi, Jay Chol; Jang, Min Uk; Kang, Kyusik; Park, Jong-Moo; Ko, Youngchai; Lee, Soo-Joo; Cha, Jae-Kwan; Kim, Dae-Hyun; Park, Sang Soon; Park, Tai Hwan; Lee, Kyung Bok; Lee, Jun; Kim, Joon-Tae; Cho, Ki-Hyun; Yu, Kyung-Ho; Oh, Mi-Sun; Lee, Byung-Chul; Cho, Yong-Jin; Kim, Dong-Eog; Lee, Ji Sung; Lee, Juneyoung; Gorelick, Philip B.; Bae, Hee-Joon
%T Comparative effectiveness of standard care with IV thrombolysis versus without IV thrombolysis for mild ischemic stroke.
%J Journal of the American Heart Association, vol. 4, no. 1, p. e001306
%D 01/2015
%V 4
%N 1
%M eng
%B One third of patients presenting with initially mild strokes have unfavorable outcomes, and the efficacy of intravenous thrombolysis (IVT) in this population has not been proven. This study aimed to evaluate the comparative effectiveness of standard care with IVT versus without IVT in mild stroke patients.
%K Aged, Brain Ischemia, Databases, Factual, Female, Fibrinolytic Agents, Follow-Up Studies, Humans, Infusions, Intravenous, Logistic Models, Male, Middle Aged, Multivariate Analysis, Odds Ratio, Registries, Retrospective Studies, Risk Assessment, Severity of Illness Index, Stroke, Survival Rate, Thrombolytic Therapy, Time Factors, Treatment Outcome
%P e001306
%Y 10.1161/JAHA.114.000596
%W PHY
%G AUTHOR
%R 2015........4....0C

@Article{Choi2015,
author="Choi, Jay Chol
and Jang, Min Uk
and Kang, Kyusik
and Park, Jong-Moo
and Ko, Youngchai
and Lee, Soo-Joo
and Cha, Jae-Kwan
and Kim, Dae-Hyun
and Park, Sang Soon
and Park, Tai Hwan
and Lee, Kyung Bok
and Lee, Jun
and Kim, Joon-Tae
and Cho, Ki-Hyun
and Yu, Kyung-Ho
and Oh, Mi-Sun
and Lee, Byung-Chul
and Cho, Yong-Jin
and Kim, Dong-Eog
and Lee, Ji Sung
and Lee, Juneyoung
and Gorelick, Philip B.
and Bae, Hee-Joon",
title="Comparative effectiveness of standard care with IV thrombolysis versus without IV thrombolysis for mild ischemic stroke.",
journal="Journal of the American Heart Association",
year="2015",
month="Jan",
day="27",
volume="4",
number="1",
pages="e001306",
keywords="Aged",
keywords="Brain Ischemia",
keywords="Databases, Factual",
keywords="Female",
keywords="Fibrinolytic Agents",
keywords="Follow-Up Studies",
keywords="Humans",
keywords="Infusions, Intravenous",
keywords="Logistic Models",
keywords="Male",
keywords="Middle Aged",
keywords="Multivariate Analysis",
keywords="Odds Ratio",
keywords="Registries",
keywords="Retrospective Studies",
keywords="Risk Assessment",
keywords="Severity of Illness Index",
keywords="Stroke",
keywords="Survival Rate",
keywords="Thrombolytic Therapy",
keywords="Time Factors",
keywords="Treatment Outcome",
abstract="One third of patients presenting with initially mild strokes have unfavorable outcomes, and the efficacy of intravenous thrombolysis (IVT) in this population has not been proven. This study aimed to evaluate the comparative effectiveness of standard care with IVT versus without IVT in mild stroke patients.",
issn="2047-9980",
doi="10.1161/JAHA.114.000596",
url="http://www.ncbi.nlm.nih.gov/pubmed/25628404",
language="eng"
}

%0 Journal Article
%T Comparative effectiveness of standard care with IV thrombolysis versus without IV thrombolysis for mild ischemic stroke.
%A Choi, Jay Chol
%A Jang, Min Uk
%A Kang, Kyusik
%A Park, Jong-Moo
%A Ko, Youngchai
%A Lee, Soo-Joo
%A Cha, Jae-Kwan
%A Kim, Dae-Hyun
%A Park, Sang Soon
%A Park, Tai Hwan
%A Lee, Kyung Bok
%A Lee, Jun
%A Kim, Joon-Tae
%A Cho, Ki-Hyun
%A Yu, Kyung-Ho
%A Oh, Mi-Sun
%A Lee, Byung-Chul
%A Cho, Yong-Jin
%A Kim, Dong-Eog
%A Lee, Ji Sung
%A Lee, Juneyoung
%A Gorelick, Philip B.
%A Bae, Hee-Joon
%J Journal of the American Heart Association
%D 2015
%8 Jan 27
%V 4
%N 1
%@ 2047-9980
%G eng
%F Choi2015
%X One third of patients presenting with initially mild strokes have unfavorable outcomes, and the efficacy of intravenous thrombolysis (IVT) in this population has not been proven. This study aimed to evaluate the comparative effectiveness of standard care with IVT versus without IVT in mild stroke patients.
%K Aged
%K Brain Ischemia
%K Databases, Factual
%K Female
%K Fibrinolytic Agents
%K Follow-Up Studies
%K Humans
%K Infusions, Intravenous
%K Logistic Models
%K Male
%K Middle Aged
%K Multivariate Analysis
%K Odds Ratio
%K Registries
%K Retrospective Studies
%K Risk Assessment
%K Severity of Illness Index
%K Stroke
%K Survival Rate
%K Thrombolytic Therapy
%K Time Factors
%K Treatment Outcome
%U http://dx.doi.org/10.1161/JAHA.114.000596
%U http://www.ncbi.nlm.nih.gov/pubmed/25628404
%P e001306

PT Journal
AU Choi, JC
   Jang, MU
   Kang, K
   Park, J
   Ko, Y
   Lee, S
   Cha, J
   Kim, D
   Park, SS
   Park, TH
   Lee, KB
   Lee, J
   Kim, J
   Cho, K
   Yu, K
   Oh, M
   Lee, B
   Cho, Y
   Kim, D
   Lee, JS
   Lee, J
   Gorelick, PB
   Bae, H
TI Comparative effectiveness of standard care with IV thrombolysis versus without IV thrombolysis for mild ischemic stroke.
SO Journal of the American Heart Association
JI J Am Heart Assoc
PD Jan
PY 2015
BP e001306
VL 4
IS 1
DI 10.1161/JAHA.114.000596
LA eng
DE Aged; Brain Ischemia; Databases, Factual; Female; Fibrinolytic Agents; Follow-Up Studies; Humans; Infusions, Intravenous; Logistic Models; Male; Middle Aged; Multivariate Analysis; Odds Ratio; Registries; Retrospective Studies; Risk Assessment; Severity of Illness Index; Stroke; Survival Rate; Thrombolytic Therapy; Time Factors; Treatment Outcome
AB One third of patients presenting with initially mild strokes have unfavorable outcomes, and the efficacy of intravenous thrombolysis (IVT) in this population has not been proven. This study aimed to evaluate the comparative effectiveness of standard care with IVT versus without IVT in mild stroke patients.
ER

PMID- 25628404
OWN - NLM
STAT- MEDLINE
DA  - 20150128
DCOM- 20160418
LR  - 20150228
IS  - 2047-9980 (Electronic)
IS  - 2047-9980 (Linking)
VI  - 4
IP  - 1
DP  - 2015 Jan
TI  - Comparative effectiveness of standard care with IV thrombolysis versus without IV
      thrombolysis for mild ischemic stroke.
PG  - e001306
LID - 10.1161/JAHA.114.000596 [doi]
LID - e000596 [pii]
AB  - BACKGROUND: One third of patients presenting with initially mild strokes have
      unfavorable outcomes, and the efficacy of intravenous thrombolysis (IVT) in this 
      population has not been proven. This study aimed to evaluate the comparative
      effectiveness of standard care with IVT versus without IVT in mild stroke
      patients. METHODS AND RESULTS: Using a multicenter stroke registry database, we
      identified patients with acute ischemic stroke who presented within 4.5 hours of 
      symptom onset and had initial National Institutes of Health Stroke Scale scores
      </=5. Multivariable logistic analysis and propensity score matching were used to 
      adjust for baseline imbalances between the patients who did and did not receive
      IVT. Adjusted odds ratios and 95% CIs of IVT were estimated for 3-month modified 
      Rankin Scale scores of 0 to 1 and symptomatic. Of 13 117 patients with stroke who
      were hospitalized between April 2008 and May 2012, 1386 met the eligibility
      criteria, and 194 (14.0%) were treated with IVT. For a modified Rankin Scale of 0
      to 1 at 3 months, the adjusted odds ratios were 1.96 (95% CI, 1.28 to 3.00;
      P=0.002) by multivariable logistic analysis and 1.68 (1.10 to 2.56; P=0.02) by
      propensity score matching analysis, respectively. There was a statistically
      nonsignificant excess of symptomatic hemorrhagic transformation (odds ratios=3.76
      [0.95 to 16.42; P=0.06] and 4.81 [0.84 to 49.34; P=0.09]), respectively.
      CONCLUSIONS: In this observational registry-based study, standard care with IVT
      is more effective than not receiving IVT in mildischemic stroke patients, and
      there is a statistically nonsignificant risk of symptomatic hemorrhagic
      transformation.
FAU - Choi, Jay Chol
AU  - Choi JC
FAU - Jang, Min Uk
AU  - Jang MU
FAU - Kang, Kyusik
AU  - Kang K
FAU - Park, Jong-Moo
AU  - Park JM
FAU - Ko, Youngchai
AU  - Ko Y
FAU - Lee, Soo-Joo
AU  - Lee SJ
FAU - Cha, Jae-Kwan
AU  - Cha JK
FAU - Kim, Dae-Hyun
AU  - Kim DH
FAU - Park, Sang Soon
AU  - Park SS
FAU - Park, Tai Hwan
AU  - Park TH
FAU - Lee, Kyung Bok
AU  - Lee KB
FAU - Lee, Jun
AU  - Lee J
FAU - Kim, Joon-Tae
AU  - Kim JT
FAU - Cho, Ki-Hyun
AU  - Cho KH
FAU - Yu, Kyung-Ho
AU  - Yu KH
FAU - Oh, Mi-Sun
AU  - Oh MS
FAU - Lee, Byung-Chul
AU  - Lee BC
FAU - Cho, Yong-Jin
AU  - Cho YJ
FAU - Kim, Dong-Eog
AU  - Kim DE
FAU - Lee, Ji Sung
AU  - Lee JS
FAU - Lee, Juneyoung
AU  - Lee J
FAU - Gorelick, Philip B
AU  - Gorelick PB
FAU - Bae, Hee-Joon
AU  - Bae HJ
LA  - eng
SI  - ClinicalTrials.gov/NCT02072226
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20150127
PL  - England
TA  - J Am Heart Assoc
JT  - Journal of the American Heart Association
JID - 101580524
RN  - 0 (Fibrinolytic Agents)
SB  - IM
MH  - Aged
MH  - Brain Ischemia/complications/*drug therapy/mortality
MH  - Databases, Factual
MH  - Female
MH  - Fibrinolytic Agents/*administration & dosage
MH  - Follow-Up Studies
MH  - Humans
MH  - Infusions, Intravenous
MH  - Logistic Models
MH  - Male
MH  - Middle Aged
MH  - Multivariate Analysis
MH  - Odds Ratio
MH  - *Registries
MH  - Retrospective Studies
MH  - Risk Assessment
MH  - Severity of Illness Index
MH  - Stroke/*drug therapy/etiology/mortality
MH  - Survival Rate
MH  - Thrombolytic Therapy/*methods
MH  - Time Factors
MH  - Treatment Outcome
PMC - PMC4330057
OID - NLM: PMC4330057
EDAT- 2015/01/30 06:00
MHDA- 2016/04/19 06:00
CRDT- 2015/01/29 06:00
AID - jah3849 [pii]
AID - 10.1161/JAHA.114.000596 [doi]
PST - epublish
SO  - J Am Heart Assoc. 2015 Jan 27;4(1):e001306. doi: 10.1161/JAHA.114.000596.
TY  - JOUR
AU  - Choi, Jay Chol
AU  - Jang, Min Uk
AU  - Kang, Kyusik
AU  - Park, Jong-Moo
AU  - Ko, Youngchai
AU  - Lee, Soo-Joo
AU  - Cha, Jae-Kwan
AU  - Kim, Dae-Hyun
AU  - Park, Sang Soon
AU  - Park, Tai Hwan
AU  - Lee, Kyung Bok
AU  - Lee, Jun
AU  - Kim, Joon-Tae
AU  - Cho, Ki-Hyun
AU  - Yu, Kyung-Ho
AU  - Oh, Mi-Sun
AU  - Lee, Byung-Chul
AU  - Cho, Yong-Jin
AU  - Kim, Dong-Eog
AU  - Lee, Ji Sung
AU  - Lee, Juneyoung
AU  - Gorelick, Philip B.
AU  - Bae, Hee-Joon
PY  - 2015/Jan/27
TI  - Comparative effectiveness of standard care with IV thrombolysis versus without IV thrombolysis for mild ischemic stroke.
T2  - J Am Heart Assoc
JO  - Journal of the American Heart Association
SP  - e001306
VL  - 4
IS  - 1
KW  - Aged
KW  - Brain Ischemia
KW  - Databases, Factual
KW  - Female
KW  - Fibrinolytic Agents
KW  - Follow-Up Studies
KW  - Humans
KW  - Infusions, Intravenous
KW  - Logistic Models
KW  - Male
KW  - Middle Aged
KW  - Multivariate Analysis
KW  - Odds Ratio
KW  - Registries
KW  - Retrospective Studies
KW  - Risk Assessment
KW  - Severity of Illness Index
KW  - Stroke
KW  - Survival Rate
KW  - Thrombolytic Therapy
KW  - Time Factors
KW  - Treatment Outcome
N2  - One third of patients presenting with initially mild strokes have unfavorable outcomes, and the efficacy of intravenous thrombolysis (IVT) in this population has not been proven. This study aimed to evaluate the comparative effectiveness of standard care with IVT versus without IVT in mild stroke patients.
SN  - 2047-9980
UR  - http://dx.doi.org/10.1161/JAHA.114.000596
UR  - http://www.ncbi.nlm.nih.gov/pubmed/25628404
ID  - Choi2015
ER  - 
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