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Investigation of novel autoantibodies in Sjogren's syndrome utilizing Sera from the Sjogren's international collaborative clinical alliance cohort.

Abstract Sjogren's syndrome (SS) is a chronic autoimmune disease mainly affecting salivary and lacrimal glands. Current diagnostic criteria for SS utilize anti-Ro and anti-La as serological markers. Animal models for SS have identified novel autoantibodies, anti-salivary gland protein 1 (SP1), anti-carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP). These novel antibodies are seen in the animals at an earlier stage of SS than anti-Ro and anti-La. The current studies were designed to evaluate these novel autoantibodies in the sera of well-characterized patients with dry eyes and dry mouth and lip biopsies from the Sjogren's International Collaborative Clinical Alliance (SICCA) to determine if they indeed identify SS with less severe disease than patients expressing anti-Ro and anti-La.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title bmc ophthalmology
Publication Year Start




PMID- 25881294
OWN - NLM
STAT- MEDLINE
DA  - 20150417
DCOM- 20160120
LR  - 20161019
IS  - 1471-2415 (Electronic)
IS  - 1471-2415 (Linking)
VI  - 15
DP  - 2015 Apr 10
TI  - Investigation of novel autoantibodies in Sjogren's syndrome utilizing Sera from
      the Sjogren's international collaborative clinical alliance cohort.
PG  - 38
LID - 10.1186/s12886-015-0023-1 [doi]
AB  - BACKGROUND: Sjogren's syndrome (SS) is a chronic autoimmune disease mainly
      affecting salivary and lacrimal glands. Current diagnostic criteria for SS
      utilize anti-Ro and anti-La as serological markers. Animal models for SS have
      identified novel autoantibodies, anti-salivary gland protein 1 (SP1),
      anti-carbonic anhydrase 6 (CA6) and parotid secretory protein (PSP). These novel 
      antibodies are seen in the animals at an earlier stage of SS than anti-Ro and
      anti-La. The current studies were designed to evaluate these novel autoantibodies
      in the sera of well-characterized patients with dry eyes and dry mouth and lip
      biopsies from the Sjogren's International Collaborative Clinical Alliance (SICCA)
      to determine if they indeed identify SS with less severe disease than patients
      expressing anti-Ro and anti-La. METHODS: Sera were obtained from SICCA registry
      in patients for whom lymphocytic foci per 4 mm(2) on the lip biopsies was either 
      0 (F = 0), <1 (F <1) or > 3 (F >3). ELISA assays were utilized to evaluate these 
      sera for anti-Ro, anti-La, anti-SP1, anti-CA6, and anti-PSP. RESULTS: In patients
      with dry eyes and dry mouth but F = 0, increased expression of anti- CA6 was
      noted compared to the F <1 group (p = .032) or the F > 3 group (p = .006).
      Neither anti-PSP nor anti-SP1 reached statistical significance because of the
      small numbers in the F0 group, although there was a trend for their expression to
      be higher in the F0 group. On the other hand, the expression of anti-Ro was
      significantly reduced in the F0 group compared to the F <1 (p = .0021) and F > 3 
      (p = .0003) groups. The reduced expression of anti-La in the F0 group compared to
      the F <1 and F > 3 groups did not quite reach statistical significance.
      CONCLUSIONS: Anti-Ro and anti-La identify patients with SS and more severe
      disease than anti-SP1, anti-CA6, and anti-PSP. More studies are needed to
      identify the timing in the course of SS when these different autoantibodies are
      expressed and/or whether they are expressed in patients with different clinical
      manifestations.
FAU - Suresh, Lakshmanan
AU  - Suresh L
AD  - Immco Diagnostics, Buffalo, NY, USA. [email protected]
AD  - Department of Oral Diagnostic Sciences, SUNY at Buffalo School of Dental
      Medicine, 3435 Main Street, Buffalo, NY, 14214, USA. [email protected]
FAU - Malyavantham, Kishore
AU  - Malyavantham K
AD  - Immco Diagnostics, Buffalo, NY, USA. [email protected]
FAU - Shen, Long
AU  - Shen L
AD  - Department of Medicine, SUNY at Buffalo School of Medicine, Buffalo, NY, USA.
      [email protected]
FAU - Ambrus, Julian L Jr
AU  - Ambrus JL Jr
AD  - Department of Medicine, SUNY at Buffalo School of Medicine, Buffalo, NY, USA.
      [email protected]
AD  - Division of Allergy, Immunology and Rheumatology, SUNY at Buffalo School of
      Medicine, Room C281, Buffalo General Hospital, 100 High Street, Buffalo, NY,
      14203, USA. [email protected]
LA  - eng
GR  - R21 DE019721/DE/NIDCR NIH HHS/United States
GR  - HHSN26S201300057C/PHS HHS/United States
GR  - 1R01DE021697-01A/DE/NIDCR NIH HHS/United States
GR  - 1R01DE022971-01/DE/NIDCR NIH HHS/United States
GR  - R01 DE022971/DE/NIDCR NIH HHS/United States
GR  - R21-DE19721-01A1/DE/NIDCR NIH HHS/United States
GR  - R01 DE021697/DE/NIDCR NIH HHS/United States
PT  - Journal Article
PT  - Research Support, N.I.H., Extramural
DEP - 20150410
PL  - England
TA  - BMC Ophthalmol
JT  - BMC ophthalmology
JID - 100967802
RN  - 0 (Autoantibodies)
RN  - 0 (Biomarkers)
SB  - IM
MH  - Animals
MH  - Autoantibodies/*blood
MH  - Biomarkers/*blood
MH  - Disease Models, Animal
MH  - Enzyme-Linked Immunosorbent Assay
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Lacrimal Apparatus/*pathology
MH  - Male
MH  - Mice
MH  - Mice, Transgenic
MH  - Middle Aged
MH  - Sjogren's Syndrome/*blood/pathology
PMC - PMC4397858
OID - NLM: PMC4397858
EDAT- 2015/04/17 06:00
MHDA- 2016/01/21 06:00
CRDT- 2015/04/17 06:00
PHST- 2014/07/28 [received]
PHST- 2015/03/23 [accepted]
AID - 10.1186/s12886-015-0023-1 [doi]
AID - 10.1186/s12886-015-0023-1 [pii]
PST - epublish
SO  - BMC Ophthalmol. 2015 Apr 10;15:38. doi: 10.1186/s12886-015-0023-1.

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