PubTransformer

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PMID- 26093795
OWN - NLM
STAT- MEDLINE
DCOM- 20160419
LR  - 20160815
IS  - 1873-2682 (Electronic)
IS  - 1011-1344 (Linking)
VI  - 149
DP  - 2015 Aug
TI  - Size of the exposed body surface area, skin erythema and body mass index predict 
      skin production of vitamin D.
PG  - 224-9
LID - 10.1016/j.jphotobiol.2015.06.008 [doi]
LID - S1011-1344(15)00197-9 [pii]
AB  - BACKGROUND: Cholecalciferol (vitamin D3), produced in the skin by UVB irradiation
      (290-315nm) of 7-dehydrocholesterol, is metabolized in the liver into
      25-hydroxyvitamin D [25(OH)D] which is a major circulating metabolite. AIM: To
      examine changes in serum concentrations of cholecalciferol and its metabolites
      after UVB exposure of different skin areas. METHODS: 21 healthy Caucasians (skin 
      type II and III, aged 23-47years) were exposed to broadband UVB (290-320nm) and
      randomized to either exposure to one minimal erythema dose given as a single
      dose, or a suberythemic dose given for 3 subsequent days. The following areas
      were exposed: face and back of hands, upper half of the body and the whole body, 
      respectively. Serum cholecalciferol and 25(OH)D were measured immediately before 
      start and 24h after the 1st and last exposure, respectively. RESULTS: Subjects
      with whole body exposure had an average S-cholecalciferol increase per dose unit 
      of 0.18ngml(-1)mJ(-1)cm(2), 0.95 CI: (0.16, 0.20), upper body treatment
      0.13ngml(-1)mJ(-1)cm(2), 0.95 CI: (0.10, 0.15) and face and hands exposure
      0.013ngml(-1)mJ(-1)cm(2), 0.95 CI: (-0.012, 0.037). The increase in
      cholecalciferol correlated positively to the UVB dose and skin erythema and
      negatively to body mass index (BMI) when controlling for other factors. Exposure 
      of face and hands induces smaller cholecalciferol production in comparison with
      exposure of larger skin areas. CONCLUSION: Size of the exposed skin area, UVB
      dose, skin erythema and BMI were the major determinants for serum levels of skin 
      synthesized cholecalciferol. Exposure of hands and face induces smaller
      cholecalciferol production in comparison with exposure of larger skin areas.
CI  - Copyright (c) 2015 Elsevier B.V. All rights reserved.
FAU - Osmancevic, Amra
AU  - Osmancevic A
AD  - Dept of Dermatology, Sahlgrenska University Hospital at Sahlgrenska Academy,
      University of Gothenburg, Sweden. Electronic address:
      [email protected]
FAU - Gillstedt, Martin
AU  - Gillstedt M
AD  - Dept of Dermatology, Sahlgrenska University Hospital at Sahlgrenska Academy,
      University of Gothenburg, Sweden.
FAU - Landin-Wilhelmsen, Kerstin
AU  - Landin-Wilhelmsen K
AD  - Institution of Medicine, Sahlgrenska University Hospital at Sahlgrenska Academy, 
      University of Gothenburg, Sweden.
FAU - Wennberg Larko, Ann-Marie
AU  - Wennberg Larko AM
AD  - Dept of Dermatology, Sahlgrenska University Hospital at Sahlgrenska Academy,
      University of Gothenburg, Sweden.
FAU - Larko, Olle
AU  - Larko O
AD  - Dept of Dermatology, Sahlgrenska University Hospital at Sahlgrenska Academy,
      University of Gothenburg, Sweden.
FAU - Holick, Michael F
AU  - Holick MF
AD  - Boston University School of Medicine, Boston, MA 02118, United States.
FAU - Krogstad, Anne-Lene
AU  - Krogstad AL
AD  - Dept of Dermatology, Sahlgrenska University Hospital at Sahlgrenska Academy,
      University of Gothenburg, Sweden; Dept of Dermatology, RH University Hospital,
      Norway.
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150612
PL  - Switzerland
TA  - J Photochem Photobiol B
JT  - Journal of photochemistry and photobiology. B, Biology
JID - 8804966
RN  - 1406-16-2 (Vitamin D)
RN  - 1C6V77QF41 (Cholecalciferol)
RN  - 64719-49-9 (25-hydroxyvitamin D)
SB  - IM
MH  - Adult
MH  - *Body Mass Index
MH  - *Body Surface Area
MH  - Cholecalciferol/*biosynthesis/blood
MH  - Dose-Response Relationship, Radiation
MH  - Erythema/blood/*metabolism
MH  - Female
MH  - Humans
MH  - Male
MH  - Middle Aged
MH  - Random Allocation
MH  - Seasons
MH  - Skin/*metabolism/radiation effects
MH  - *Ultraviolet Rays
MH  - Vitamin D/*analogs & derivatives/biosynthesis/blood
MH  - Young Adult
OTO - NOTNLM
OT  - Cholecalciferol
OT  - Skin erythema
OT  - Skin surface
OT  - UVB-dose
OT  - Vitamin D synthesis
OT  - Vitamin D(3)
EDAT- 2015/06/22 06:00
MHDA- 2016/04/20 06:00
CRDT- 2015/06/22 06:00
PHST- 2015/05/15 00:00 [received]
PHST- 2015/06/09 00:00 [revised]
PHST- 2015/06/11 00:00 [accepted]
PHST- 2015/06/22 06:00 [entrez]
PHST- 2015/06/22 06:00 [pubmed]
PHST- 2016/04/20 06:00 [medline]
AID - S1011-1344(15)00197-9 [pii]
AID - 10.1016/j.jphotobiol.2015.06.008 [doi]
PST - ppublish
SO  - J Photochem Photobiol B. 2015 Aug;149:224-9. doi:
      10.1016/j.jphotobiol.2015.06.008. Epub 2015 Jun 12.