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Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke.

Abstract A recent meta-analysis investigating the association between statins and early outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) indicated that prestroke statin treatment was associated with increased risk of 90-day mortality and symptomatic intracranial hemorrhage. We investigated the potential association of statin pretreatment with early outcomes in a large, international registry of AIS patients treated with IVT.
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Authors

Mayor MeshTerms

Outcome Assessment (Health Care)

Registries

Keywords

blood pressure

intracranial hemorrhages

risk factors

statins

stroke

Journal Title stroke; a journal of cerebral circulation
Publication Year Start
%A Tsivgoulis, Georgios; Kadlecov?, Pavla; Kobayashi, Adam; Czlonkowska, Anna; Brozman, Miroslav; ?vigelj, Viktor; Csiba, Laszlo; K?rv, Janika; Demarin, Vida; Vilionskis, Aleksandras; Jatuzis, Dalius; Katsanos, Aristeidis H.; Rudolf, Jobst; Krespi, Yakup; Mikulik, Robert
%T Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke.
%J Stroke; a journal of cerebral circulation, vol. 46, no. 9, pp. 2681-2684
%D 09/2015
%V 46
%N 9
%M eng
%B A recent meta-analysis investigating the association between statins and early outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) indicated that prestroke statin treatment was associated with increased risk of 90-day mortality and symptomatic intracranial hemorrhage. We investigated the potential association of statin pretreatment with early outcomes in a large, international registry of AIS patients treated with IVT.
%K Administration, Intravenous, Aged, Aged, 80 and over, Brain Ischemia, Europe, Female, Follow-Up Studies, Humans, Hydroxymethylglutaryl-CoA Reductase Inhibitors, Intracranial Hemorrhages, Male, Middle Aged, Mortality, Outcome Assessment (Health Care), Registries, Severity of Illness Index, Stroke, Thrombolytic Therapy
%P 2681
%L 2684
%Y 10.1161/STROKEAHA.115.010244
%W PHY
%G AUTHOR
%R 2015.......46.2681T

@Article{Tsivgoulis2015,
author="Tsivgoulis, Georgios
and Kadlecov{\'a}, Pavla
and Kobayashi, Adam
and Czlonkowska, Anna
and Brozman, Miroslav
and {\vS}vigelj, Viktor
and Csiba, Laszlo
and K{\~o}rv, Janika
and Demarin, Vida
and Vilionskis, Aleksandras
and Jatuzis, Dalius
and Katsanos, Aristeidis H.
and Rudolf, Jobst
and Krespi, Yakup
and Mikulik, Robert",
title="Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke.",
journal="Stroke; a journal of cerebral circulation",
year="2015",
month="Sep",
day="14",
volume="46",
number="9",
pages="2681--2684",
keywords="Administration, Intravenous",
keywords="Aged",
keywords="Aged, 80 and over",
keywords="Brain Ischemia",
keywords="Europe",
keywords="Female",
keywords="Follow-Up Studies",
keywords="Humans",
keywords="Hydroxymethylglutaryl-CoA Reductase Inhibitors",
keywords="Intracranial Hemorrhages",
keywords="Male",
keywords="Middle Aged",
keywords="Mortality",
keywords="Outcome Assessment (Health Care)",
keywords="Registries",
keywords="Severity of Illness Index",
keywords="Stroke",
keywords="Thrombolytic Therapy",
abstract="A recent meta-analysis investigating the association between statins and early outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) indicated that prestroke statin treatment was associated with increased risk of 90-day mortality and symptomatic intracranial hemorrhage. We investigated the potential association of statin pretreatment with early outcomes in a large, international registry of AIS patients treated with IVT.",
issn="1524-4628",
doi="10.1161/STROKEAHA.115.010244",
url="http://www.ncbi.nlm.nih.gov/pubmed/26173726",
language="eng"
}

%0 Journal Article
%T Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke.
%A Tsivgoulis, Georgios
%A Kadlecov?, Pavla
%A Kobayashi, Adam
%A Czlonkowska, Anna
%A Brozman, Miroslav
%A ?vigelj, Viktor
%A Csiba, Laszlo
%A K?rv, Janika
%A Demarin, Vida
%A Vilionskis, Aleksandras
%A Jatuzis, Dalius
%A Katsanos, Aristeidis H.
%A Rudolf, Jobst
%A Krespi, Yakup
%A Mikulik, Robert
%J Stroke; a journal of cerebral circulation
%D 2015
%8 Sep 14
%V 46
%N 9
%@ 1524-4628
%G eng
%F Tsivgoulis2015
%X A recent meta-analysis investigating the association between statins and early outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) indicated that prestroke statin treatment was associated with increased risk of 90-day mortality and symptomatic intracranial hemorrhage. We investigated the potential association of statin pretreatment with early outcomes in a large, international registry of AIS patients treated with IVT.
%K Administration, Intravenous
%K Aged
%K Aged, 80 and over
%K Brain Ischemia
%K Europe
%K Female
%K Follow-Up Studies
%K Humans
%K Hydroxymethylglutaryl-CoA Reductase Inhibitors
%K Intracranial Hemorrhages
%K Male
%K Middle Aged
%K Mortality
%K Outcome Assessment (Health Care)
%K Registries
%K Severity of Illness Index
%K Stroke
%K Thrombolytic Therapy
%U http://dx.doi.org/10.1161/STROKEAHA.115.010244
%U http://www.ncbi.nlm.nih.gov/pubmed/26173726
%P 2681-2684

PT Journal
AU Tsivgoulis, G
   Kadlecov?, P
   Kobayashi, A
   Czlonkowska, A
   Brozman, M
   ?vigelj, V
   Csiba, L
   K?rv, J
   Demarin, V
   Vilionskis, A
   Jatuzis, D
   Katsanos, AH
   Rudolf, J
   Krespi, Y
   Mikulik, R
TI Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke.
SO Stroke; a journal of cerebral circulation
JI Stroke
PD Sep
PY 2015
BP 2681
EP 2684
VL 46
IS 9
DI 10.1161/STROKEAHA.115.010244
LA eng
DE Administration, Intravenous; Aged; Aged, 80 and over; Brain Ischemia; Europe; Female; Follow-Up Studies; Humans; Hydroxymethylglutaryl-CoA Reductase Inhibitors; Intracranial Hemorrhages; Male; Middle Aged; Mortality; Outcome Assessment (Health Care); Registries; Severity of Illness Index; Stroke; Thrombolytic Therapy
AB A recent meta-analysis investigating the association between statins and early outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) indicated that prestroke statin treatment was associated with increased risk of 90-day mortality and symptomatic intracranial hemorrhage. We investigated the potential association of statin pretreatment with early outcomes in a large, international registry of AIS patients treated with IVT.
ER

PMID- 26173726
OWN - NLM
STAT- MEDLINE
DA  - 20150825
DCOM- 20151203
IS  - 1524-4628 (Electronic)
IS  - 0039-2499 (Linking)
VI  - 46
IP  - 9
DP  - 2015 Sep
TI  - Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic
      Stroke.
PG  - 2681-4
LID - 10.1161/STROKEAHA.115.010244 [doi]
AB  - BACKGROUND AND PURPOSE: A recent meta-analysis investigating the association
      between statins and early outcomes in acute ischemic stroke (AIS) patients
      treated with intravenous thrombolysis (IVT) indicated that prestroke statin
      treatment was associated with increased risk of 90-day mortality and symptomatic 
      intracranial hemorrhage. We investigated the potential association of statin
      pretreatment with early outcomes in a large, international registry of AIS
      patients treated with IVT. METHODS: We analyzed prospectively collected data from
      the Safe Implementation of Treatments in Stroke-East registry (SITS-EAST)
      registry on consecutive AIS patients treated with IVT during an 8-year period.
      Early clinical recovery within 24 hours was defined as reduction in baseline
      National Institutes of Health Stroke Scale score of >/=10 points. Favorable
      functional outcome at 3 months was defined as modified Rankin Scale scores of 0
      to 1. Symptomatic intracranial hemorrhage was diagnosed using National Institute 
      of Neurological Disorders and Stroke, European-Australasian Acute Stroke Study-II
      and SITS definitions. RESULTS: A total of 1660 AIS patients treated with IVT
      fulfilled our inclusion criteria. Patients with statin pretreatment (23%) had
      higher baseline stroke severity compared with cases who had not received any
      statin at symptom onset. After adjusting for potential confounders, statin
      pretreatment was not associated with a higher likelihood of symptomatic
      intracranial hemorrhage defined by any of the 3 definitions. Statin pretreatment 
      was not related to 3-month all-cause mortality (odds ratio, 0.92; 95% confidence 
      interval, 0.57-1.49; P=0.741) or 3-month favorable functional outcome (odds
      ratio, 0.81; 95% confidence interval, 0.52-1.27; P=0.364). Statin pretreatment
      was independently associated with a higher odds of early clinical recovery (odds 
      ratio, 1.91; 95% confidence interval, 1.25-2.92; P=0.003). CONCLUSIONS: Statin
      pretreatment seems not to be associated with adverse outcomes in AIS patients
      treated with IVT. The effect of statin pretreatment on early functional outcomes 
      in thrombolysed AIS patients deserves further investigation.
CI  - (c) 2015 American Heart Association, Inc.
FAU - Tsivgoulis, Georgios
AU  - Tsivgoulis G
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
      tsivgoulisgiorg@yahoo.gr.
FAU - Kadlecova, Pavla
AU  - Kadlecova P
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Kobayashi, Adam
AU  - Kobayashi A
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Czlonkowska, Anna
AU  - Czlonkowska A
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Brozman, Miroslav
AU  - Brozman M
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Svigelj, Viktor
AU  - Svigelj V
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Csiba, Laszlo
AU  - Csiba L
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Korv, Janika
AU  - Korv J
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Demarin, Vida
AU  - Demarin V
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Vilionskis, Aleksandras
AU  - Vilionskis A
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Jatuzis, Dalius
AU  - Jatuzis D
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Katsanos, Aristeidis H
AU  - Katsanos AH
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Rudolf, Jobst
AU  - Rudolf J
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Krespi, Yakup
AU  - Krespi Y
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
FAU - Mikulik, Robert
AU  - Mikulik R
AD  - From the Second Department of Neurology, "Attikon" Hospital, University of
      Athens, School of Medicine, Athens, Greece (G.T., A.H.K.); Department of
      Neurology, International Clinical Research Center, St. Anne's Hospital, Brno,
      Czech Republic (G.T., P.K., R.M.); Second Department of Neurology, Institute of
      Psychiatry and Neurology, Warsaw, Poland (A.K., A.C.); Department of Experimental
      and Clinical Pharmacology, Medical University of Warsaw, Warsaw, Poland (A.C.);
      Neurology Department, University Hospital Nitra, Nitra, Slovakia (M.B.);
      Department of Vascular Neurology and Neurological Intensive Care, University
      Medical Center Ljubljana and Zdravstveni Nasveti, Ljubljana, Slovenia (V.S.);
      Department of Neurology, Medical and Health Science Center, University of
      Debrecen, Debrecen, Hungary (L.C.); Department of Neurology and Neurosurgery,
      University of Tartu, Tartu, Estonia (J.K.); Department of Neurology, Sestre
      Milosrdnice University Hospital Centre, Zagreb, Croatia (V.D.); Department of
      Neurology and Neurosurgery, Vilnius University and Republican Vilnius University 
      Hospital, Vilnius, Lithuania (A.V.); Department of Neurology and Neurosurgery,
      Vilnius University and Vilnius University Hospital Santariskiu Clinics, Vilnius, 
      Lithuania (D.J.); Department of Neurology, "Papageorgiou Hospital", Thessaloniki,
      Greece (J.R.); and Neurology Department and Stroke Center, Istanbul Science
      University and Florence Nightingale Hospital, Istanbul, Turkey (Y.K.).
LA  - eng
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20150714
PL  - United States
TA  - Stroke
JT  - Stroke; a journal of cerebral circulation
JID - 0235266
RN  - 0 (Hydroxymethylglutaryl-CoA Reductase Inhibitors)
SB  - IM
MH  - Administration, Intravenous
MH  - Aged
MH  - Aged, 80 and over
MH  - Brain Ischemia/*drug therapy
MH  - Europe
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Hydroxymethylglutaryl-CoA Reductase Inhibitors/*administration & dosage/*adverse 
      effects
MH  - Intracranial Hemorrhages/*chemically induced
MH  - Male
MH  - Middle Aged
MH  - Mortality
MH  - *Outcome Assessment (Health Care)
MH  - *Registries
MH  - Severity of Illness Index
MH  - Stroke/*drug therapy
MH  - Thrombolytic Therapy/*methods
OTO - NOTNLM
OT  - blood pressure
OT  - intracranial hemorrhages
OT  - risk factors
OT  - statins
OT  - stroke
EDAT- 2015/07/16 06:00
MHDA- 2015/12/15 06:00
CRDT- 2015/07/16 06:00
PHST- 2015/06/01 [received]
PHST- 2015/06/10 [accepted]
PHST- 2015/07/14 [aheadofprint]
AID - STROKEAHA.115.010244 [pii]
AID - 10.1161/STROKEAHA.115.010244 [doi]
PST - ppublish
SO  - Stroke. 2015 Sep;46(9):2681-4. doi: 10.1161/STROKEAHA.115.010244. Epub 2015 Jul
      14.
TY  - JOUR
AU  - Tsivgoulis, Georgios
AU  - Kadlecov?, Pavla
AU  - Kobayashi, Adam
AU  - Czlonkowska, Anna
AU  - Brozman, Miroslav
AU  - ?vigelj, Viktor
AU  - Csiba, Laszlo
AU  - K?rv, Janika
AU  - Demarin, Vida
AU  - Vilionskis, Aleksandras
AU  - Jatuzis, Dalius
AU  - Katsanos, Aristeidis H.
AU  - Rudolf, Jobst
AU  - Krespi, Yakup
AU  - Mikulik, Robert
PY  - 2015/Sep/14
TI  - Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke.
T2  - Stroke
JO  - Stroke; a journal of cerebral circulation
SP  - 2681
EP  - 2684
VL  - 46
IS  - 9
KW  - Administration, Intravenous
KW  - Aged
KW  - Aged, 80 and over
KW  - Brain Ischemia
KW  - Europe
KW  - Female
KW  - Follow-Up Studies
KW  - Humans
KW  - Hydroxymethylglutaryl-CoA Reductase Inhibitors
KW  - Intracranial Hemorrhages
KW  - Male
KW  - Middle Aged
KW  - Mortality
KW  - Outcome Assessment (Health Care)
KW  - Registries
KW  - Severity of Illness Index
KW  - Stroke
KW  - Thrombolytic Therapy
N2  - A recent meta-analysis investigating the association between statins and early outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) indicated that prestroke statin treatment was associated with increased risk of 90-day mortality and symptomatic intracranial hemorrhage. We investigated the potential association of statin pretreatment with early outcomes in a large, international registry of AIS patients treated with IVT.
SN  - 1524-4628
UR  - http://dx.doi.org/10.1161/STROKEAHA.115.010244
UR  - http://www.ncbi.nlm.nih.gov/pubmed/26173726
ID  - Tsivgoulis2015
ER  - 
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<b:Title>Safety of Statin Pretreatment in Intravenous Thrombolysis for Acute Ischemic Stroke.</b:Title>
 <b:ShortTitle>Stroke</b:ShortTitle>
<b:Comments>A recent meta-analysis investigating the association between statins and early outcomes in acute ischemic stroke (AIS) patients treated with intravenous thrombolysis (IVT) indicated that prestroke statin treatment was associated with increased risk of 90-day mortality and symptomatic intracranial hemorrhage. We investigated the potential association of statin pretreatment with early outcomes in a large, international registry of AIS patients treated with IVT.</b:Comments>
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