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Diabetes mellitus and gynecologic cancer: molecular mechanisms, epidemiological, clinical and prognostic perspectives.

Abstract Diabetes mellitus, the prevalence of which has increased dramatically worldwide, may put patients at a higher risk of cancer. The aim of our study is the clarification of the possible mechanisms linking diabetes mellitus and gynecological cancer and their epidemiological relationship.
PMID
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Authors

Mayor MeshTerms
Keywords

Breast cancer

Diabetes mellitus

Endometrial cancer

Hyperinsulinemia

Insulin resistance

Ovarian cancer

Journal Title archives of gynecology and obstetrics
Publication Year Start
%A Vrachnis, Nikolaos; Iavazzo, Christos; Iliodromiti, Zoe; Sifakis, Stavros; Alexandrou, Andreas; Siristatidis, Charalambos; Grigoriadis, Charalambos; Botsis, Dimitrios; Creatsas, George
%T Diabetes mellitus and gynecologic cancer: molecular mechanisms, epidemiological, clinical and prognostic perspectives.
%J Archives of gynecology and obstetrics, vol. 293, no. 2, pp. 239-246
%D 02/2016
%V 293
%N 2
%M eng
%B Diabetes mellitus, the prevalence of which has increased dramatically worldwide, may put patients at a higher risk of cancer. The aim of our study is the clarification of the possible mechanisms linking diabetes mellitus and gynecological cancer and their epidemiological relationship.
%K Diabetes Complications, Diabetes Mellitus, Energy Metabolism, Female, Genital Neoplasms, Female, Humans, Hyperinsulinism, Hypoglycemic Agents, Incidence, Insulin Resistance, Insulins, Metformin, Prevalence, Prognosis, Risk Assessment, Risk Factors
%P 239
%L 246
%Y 10.1007/s00404-015-3858-z
%W PHY
%G AUTHOR
%R 2016......293..239V

@Article{Vrachnis2016,
author="Vrachnis, Nikolaos
and Iavazzo, Christos
and Iliodromiti, Zoe
and Sifakis, Stavros
and Alexandrou, Andreas
and Siristatidis, Charalambos
and Grigoriadis, Charalambos
and Botsis, Dimitrios
and Creatsas, George",
title="Diabetes mellitus and gynecologic cancer: molecular mechanisms, epidemiological, clinical and prognostic perspectives.",
journal="Archives of gynecology and obstetrics",
year="2016",
month="Feb",
day="04",
volume="293",
number="2",
pages="239--246",
keywords="Diabetes Complications",
keywords="Diabetes Mellitus",
keywords="Energy Metabolism",
keywords="Female",
keywords="Genital Neoplasms, Female",
keywords="Humans",
keywords="Hyperinsulinism",
keywords="Hypoglycemic Agents",
keywords="Incidence",
keywords="Insulin Resistance",
keywords="Insulins",
keywords="Metformin",
keywords="Prevalence",
keywords="Prognosis",
keywords="Risk Assessment",
keywords="Risk Factors",
abstract="Diabetes mellitus, the prevalence of which has increased dramatically worldwide, may put patients at a higher risk of cancer. The aim of our study is the clarification of the possible mechanisms linking diabetes mellitus and gynecological cancer and their epidemiological relationship.",
issn="1432-0711",
doi="10.1007/s00404-015-3858-z",
url="http://www.ncbi.nlm.nih.gov/pubmed/26338721",
language="eng"
}

%0 Journal Article
%T Diabetes mellitus and gynecologic cancer: molecular mechanisms, epidemiological, clinical and prognostic perspectives.
%A Vrachnis, Nikolaos
%A Iavazzo, Christos
%A Iliodromiti, Zoe
%A Sifakis, Stavros
%A Alexandrou, Andreas
%A Siristatidis, Charalambos
%A Grigoriadis, Charalambos
%A Botsis, Dimitrios
%A Creatsas, George
%J Archives of gynecology and obstetrics
%D 2016
%8 Feb 04
%V 293
%N 2
%@ 1432-0711
%G eng
%F Vrachnis2016
%X Diabetes mellitus, the prevalence of which has increased dramatically worldwide, may put patients at a higher risk of cancer. The aim of our study is the clarification of the possible mechanisms linking diabetes mellitus and gynecological cancer and their epidemiological relationship.
%K Diabetes Complications
%K Diabetes Mellitus
%K Energy Metabolism
%K Female
%K Genital Neoplasms, Female
%K Humans
%K Hyperinsulinism
%K Hypoglycemic Agents
%K Incidence
%K Insulin Resistance
%K Insulins
%K Metformin
%K Prevalence
%K Prognosis
%K Risk Assessment
%K Risk Factors
%U http://dx.doi.org/10.1007/s00404-015-3858-z
%U http://www.ncbi.nlm.nih.gov/pubmed/26338721
%P 239-246

PT Journal
AU Vrachnis, N
   Iavazzo, C
   Iliodromiti, Z
   Sifakis, S
   Alexandrou, A
   Siristatidis, C
   Grigoriadis, C
   Botsis, D
   Creatsas, G
TI Diabetes mellitus and gynecologic cancer: molecular mechanisms, epidemiological, clinical and prognostic perspectives.
SO Archives of gynecology and obstetrics
JI Arch. Gynecol. Obstet.
PD Feb
PY 2016
BP 239
EP 246
VL 293
IS 2
DI 10.1007/s00404-015-3858-z
LA eng
DE Diabetes Complications; Diabetes Mellitus; Energy Metabolism; Female; Genital Neoplasms, Female; Humans; Hyperinsulinism; Hypoglycemic Agents; Incidence; Insulin Resistance; Insulins; Metformin; Prevalence; Prognosis; Risk Assessment; Risk Factors
AB Diabetes mellitus, the prevalence of which has increased dramatically worldwide, may put patients at a higher risk of cancer. The aim of our study is the clarification of the possible mechanisms linking diabetes mellitus and gynecological cancer and their epidemiological relationship.
ER

PMID- 26338721
OWN - NLM
STAT- MEDLINE
DA  - 20160112
DCOM- 20160523
IS  - 1432-0711 (Electronic)
IS  - 0932-0067 (Linking)
VI  - 293
IP  - 2
DP  - 2016 Feb
TI  - Diabetes mellitus and gynecologic cancer: molecular mechanisms, epidemiological, 
      clinical and prognostic perspectives.
PG  - 239-46
LID - 10.1007/s00404-015-3858-z [doi]
AB  - INTRODUCTION: Diabetes mellitus, the prevalence of which has increased
      dramatically worldwide, may put patients at a higher risk of cancer. The aim of
      our study is the clarification of the possible mechanisms linking diabetes
      mellitus and gynecological cancer and their epidemiological relationship.
      MATERIALS AND METHODS: This is a narrative review of the current literature,
      following a search on MEDLINE and the Cochrane Library, from their inception
      until January 2012. Articles investigating gynecologic cancer (endometrial,
      ovarian, and breast) incidence in diabetic patients were extracted. RESULTS: The 
      strong evidence for a positive association between diabetes mellitus and the risk
      for cancer indicates that energy intake in excess to energy expenditure, or the
      sequelae thereof, is involved in gynecological carcinogenesis. This risk may be
      further heightened by glucose which can directly promote the production of tumor 
      cells by functioning as a source of energy. Insulin resistance accompanied by
      secondary hyperinsulinemia is hypothezised to have a mitogenic effect. Steroid
      hormones are in addition potent regulators of the balance between cellular
      differentiation, proliferation, and apoptosis. Inflammatory pathways may also be 
      implicated, as a correlation seems to exist between diabetes mellitus and breast 
      or endometrial carcinoma pathogenesis, although an analogous correlation with
      ovarian carcinoma is still under investigation. Antidiabetic agents have been
      correlated with elevated cancer risk, while metformin seems to lower the risk.
      CONCLUSION: Diabetes mellitus is associated with an elevation in gynecologic
      cancer risk. Moreover, there are many studies exploring the prognosis of patients
      with diabetes and gynecological cancer, the outcome and the overall survival in
      well-regulated patients.
FAU - Vrachnis, Nikolaos
AU  - Vrachnis N
AD  - 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of
      Athens Medical School, Athens, Greece.
FAU - Iavazzo, Christos
AU  - Iavazzo C
AD  - 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of
      Athens Medical School, Athens, Greece.
FAU - Iliodromiti, Zoe
AU  - Iliodromiti Z
AD  - 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of
      Athens Medical School, Athens, Greece.
FAU - Sifakis, Stavros
AU  - Sifakis S
AD  - Department of Obstetrics and Gynecology, University Hospital of Heraklion, Crete,
      71201, Heraklion, Greece. [email protected]
FAU - Alexandrou, Andreas
AU  - Alexandrou A
AD  - 1st Department of Surgery, Laiko Hospital, University of Athens Medical School,
      Athens, Greece.
FAU - Siristatidis, Charalambos
AU  - Siristatidis C
AD  - 3rd Department of Obstetrics and Gynecology, University of Athens, Athens,
      Greece.
FAU - Grigoriadis, Charalambos
AU  - Grigoriadis C
AD  - 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of
      Athens Medical School, Athens, Greece.
FAU - Botsis, Dimitrios
AU  - Botsis D
AD  - 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of
      Athens Medical School, Athens, Greece.
FAU - Creatsas, George
AU  - Creatsas G
AD  - 2nd Department of Obstetrics and Gynecology, Aretaieio Hospital, University of
      Athens Medical School, Athens, Greece.
LA  - eng
PT  - Journal Article
PT  - Review
DEP - 20150904
PL  - Germany
TA  - Arch Gynecol Obstet
JT  - Archives of gynecology and obstetrics
JID - 8710213
RN  - 0 (Hypoglycemic Agents)
RN  - 0 (Insulins)
RN  - 9100L32L2N (Metformin)
SB  - IM
MH  - Diabetes Complications/*epidemiology/physiopathology
MH  - Diabetes Mellitus/*drug therapy/epidemiology/physiopathology
MH  - Energy Metabolism
MH  - Female
MH  - Genital Neoplasms, Female/*epidemiology/pathology
MH  - Humans
MH  - Hyperinsulinism/epidemiology
MH  - Hypoglycemic Agents/administration & dosage/*adverse effects/therapeutic use
MH  - Incidence
MH  - Insulin Resistance
MH  - Insulins/administration & dosage/*adverse effects
MH  - Metformin/therapeutic use
MH  - Prevalence
MH  - Prognosis
MH  - Risk Assessment
MH  - Risk Factors
OTO - NOTNLM
OT  - Breast cancer
OT  - Diabetes mellitus
OT  - Endometrial cancer
OT  - Hyperinsulinemia
OT  - Insulin resistance
OT  - Ovarian cancer
EDAT- 2015/09/05 06:00
MHDA- 2016/05/24 06:00
CRDT- 2015/09/05 06:00
PHST- 2014/05/18 [received]
PHST- 2015/08/18 [accepted]
PHST- 2015/09/04 [aheadofprint]
AID - 10.1007/s00404-015-3858-z [doi]
AID - 10.1007/s00404-015-3858-z [pii]
PST - ppublish
SO  - Arch Gynecol Obstet. 2016 Feb;293(2):239-46. doi: 10.1007/s00404-015-3858-z. Epub
      2015 Sep 4.
TY  - JOUR
AU  - Vrachnis, Nikolaos
AU  - Iavazzo, Christos
AU  - Iliodromiti, Zoe
AU  - Sifakis, Stavros
AU  - Alexandrou, Andreas
AU  - Siristatidis, Charalambos
AU  - Grigoriadis, Charalambos
AU  - Botsis, Dimitrios
AU  - Creatsas, George
PY  - 2016/Feb/04
TI  - Diabetes mellitus and gynecologic cancer: molecular mechanisms, epidemiological, clinical and prognostic perspectives.
T2  - Arch. Gynecol. Obstet.
JO  - Archives of gynecology and obstetrics
SP  - 239
EP  - 246
VL  - 293
IS  - 2
KW  - Diabetes Complications
KW  - Diabetes Mellitus
KW  - Energy Metabolism
KW  - Female
KW  - Genital Neoplasms, Female
KW  - Humans
KW  - Hyperinsulinism
KW  - Hypoglycemic Agents
KW  - Incidence
KW  - Insulin Resistance
KW  - Insulins
KW  - Metformin
KW  - Prevalence
KW  - Prognosis
KW  - Risk Assessment
KW  - Risk Factors
N2  - Diabetes mellitus, the prevalence of which has increased dramatically worldwide, may put patients at a higher risk of cancer. The aim of our study is the clarification of the possible mechanisms linking diabetes mellitus and gynecological cancer and their epidemiological relationship.
SN  - 1432-0711
UR  - http://dx.doi.org/10.1007/s00404-015-3858-z
UR  - http://www.ncbi.nlm.nih.gov/pubmed/26338721
ID  - Vrachnis2016
ER  - 
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