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Comparison of 2-year mortality according to obesity in stabilized patients with type 2 diabetes mellitus after acute myocardial infarction: results from the DIAMOND prospective cohort registry.

Abstract After acute myocardial infarction (AMI), the replicated phenomenon of obesity paradox, i.e., obesity appearing to be associated with increased survival, has not been evaluated in stabilized (i.e., without clinical events within 1 month post AMI) Asian patients with diabetes mellitus (DM).
PMID
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Authors

Mayor MeshTerms

Mortality

Registries

Keywords
Journal Title cardiovascular diabetology
Publication Year Start




PMID- 26471283
OWN - NLM
STAT- MEDLINE
DA  - 20151016
DCOM- 20160707
LR  - 20151018
IS  - 1475-2840 (Electronic)
IS  - 1475-2840 (Linking)
VI  - 14
DP  - 2015 Oct 15
TI  - Comparison of 2-year mortality according to obesity in stabilized patients with
      type 2 diabetes mellitus after acute myocardial infarction: results from the
      DIAMOND prospective cohort registry.
PG  - 141
LID - 10.1186/s12933-015-0305-1 [doi]
AB  - BACKGROUND: After acute myocardial infarction (AMI), the replicated phenomenon of
      obesity paradox, i.e., obesity appearing to be associated with increased
      survival, has not been evaluated in stabilized (i.e., without clinical events
      within 1 month post AMI) Asian patients with diabetes mellitus (DM). METHODS:
      Among 1192 patients in the DIabetic Acute Myocardial InfarctiON Disease (DIAMOND)
      Korean multicenter registry between April 2010 and June 2012, 2-year cardiac and 
      all-cause death were compared according to obesity (body mass index >/=25
      kg/m(2)) in 1125 stabilized DM patients. RESULTS: Compared with non-obese DM
      patients (62% of AMI patients), obese DM patients had: higher incidence of
      dyslipidemia (31 vs. 24%, P < 0.01); lower incidence of chronic kidney disease
      (26 vs. 33%) (P < 0.01); higher left ventricular ejection fraction after AMI (53 
      +/- 11 vs. 50 +/- 12%, P < 0.001); and lower 2-year cardiac and all-cause death
      occurrence (0.7 vs. 3.6% and 1.9 vs. 5.2%, both P < 0.01) and cumulative
      incidence in Kaplan-Meier analysis (P < 0.005, respectively). Likewise, both
      univariate and multivariate Cox hazard regression analyses adjusted for the
      respective confounders showed that obesity was associated with decreased risk of 
      both cardiac [HR, 0.18 (95% CI 0.06-0.60), P = 0.005; and 0.24 (0.07-0.78), P =
      0.018, respectively] and all-cause death [0.34 (0.16-0.73), P = 0.005; and 0.44
      (0.20-0.95), P = 0.038]. CONCLUSIONS: In a Korean population of stabilized DM
      patients after AMI, non-obese patients appear to have higher cardiac and
      all-cause mortality compared with obese patients after adjusting for confounding 
      factors.
FAU - Won, Ki-Bum
AU  - Won KB
AD  - Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South 
      Korea. [email protected]
FAU - Hur, Seung-Ho
AU  - Hur SH
AD  - Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South 
      Korea. [email protected]
FAU - Cho, Yun-Kyeong
AU  - Cho YK
AD  - Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South 
      Korea. [email protected]
FAU - Yoon, Hyuck-Jun
AU  - Yoon HJ
AD  - Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South 
      Korea. [email protected]
FAU - Nam, Chang-Wook
AU  - Nam CW
AD  - Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South 
      Korea. [email protected]
FAU - Kim, Kwon-Bae
AU  - Kim KB
AD  - Division of Cardiology, Keimyung University Dongsan Medical Center, Daegu, South 
      Korea. [email protected]
FAU - Bae, Jang-Ho
AU  - Bae JH
AD  - Division of Cardiology, Konyang University Hospital, Daejeon, South Korea.
      [email protected]
FAU - Choi, Dong-Ju
AU  - Choi DJ
AD  - Division of Cardiology, Seoul National University Bundang Hospital, Seongnam,
      South Korea. [email protected]
FAU - Ahn, Young-Keun
AU  - Ahn YK
AD  - Division of Cardiology, Chonnam National University Hospital, Gwangju, South
      Korea. [email protected]
FAU - Park, Jong-Seon
AU  - Park JS
AD  - Division of Cardiology, Yeungnam University Hospital, Daegu, South Korea.
      [email protected]
FAU - Kim, Hyo-Soo
AU  - Kim HS
AD  - Division of Cardiology, Seoul National University Hospital, 28 Yeongeon-dong,
      Chongno-gu, Seoul, 110-744, South Korea. [email protected]
FAU - Choi, Rak-Kyeong
AU  - Choi RK
AD  - Division of Cardiology, Sejong General Hospital, Bucheon, South Korea.
      [email protected]
FAU - Choi, Donghoon
AU  - Choi D
AD  - Division of Cardiology, Yonsei University Severance Hospital, Seoul, South Korea.
      [email protected]
FAU - Kim, Joon-Hong
AU  - Kim JH
AD  - Division of Cardiology, Pusan National University Yangsan Hospital, Yangsan,
      South Korea. [email protected]
FAU - Han, Kyoo-Rok
AU  - Han KR
AD  - Division of Cardiology, Hallym University Kangdong Sacred Heart Hospital, Seoul, 
      South Korea. [email protected]
FAU - Park, Hun-Sik
AU  - Park HS
AD  - Division of Cardiology, Kyungpook National University Hospital, Daegu, South
      Korea. [email protected]
FAU - Choi, So-Yeon
AU  - Choi SY
AD  - Division of Cardiology, Ajou University Hospital, Suwon, South Korea.
      [email protected]
FAU - Yoon, Jung-Han
AU  - Yoon JH
AD  - Division of Cardiology, Wonju Severance Christian Hospital, Wonju, South Korea.
      [email protected]
FAU - Kwon, Hyeon-Cheol
AU  - Kwon HC
AD  - Division of Cardiology, Samsung Medical Center, Seoul, South Korea.
      [email protected]
FAU - Rha, Seung-Un
AU  - Rha SU
AD  - Division of Cardiology, Korea University Guro Hospital, Seoul, South Korea.
      [email protected]
FAU - Hwang, Kyung-Kuk
AU  - Hwang KK
AD  - Division of Cardiology, Chungbuk National University Hospital, Cheongju, South
      Korea. [email protected]
FAU - Lim, Do-Sun
AU  - Lim DS
AD  - Division of Cardiology, Korea University Anam Hospital, Seoul, South Korea.
      [email protected]
FAU - Jung, Kyung-Tae
AU  - Jung KT
AD  - Division of Cardiology, Eulji University Hospital, Daejeon, South Korea.
      [email protected]
FAU - Oh, Seok-Kyu
AU  - Oh SK
AD  - Division of Cardiology, Wonkwang University Hospital, Iksan, South Korea.
      [email protected]
FAU - Lee, Jae-Hwan
AU  - Lee JH
AD  - Division of Cardiology, Chungnam National University Hospital, Daejeon, South
      Korea. [email protected]
FAU - Shin, Eun-Seok
AU  - Shin ES
AD  - Division of Cardiology, Ulsan University Hospital, Ulsan, South Korea.
      [email protected]
FAU - Kim, Kee-Sik
AU  - Kim KS
AD  - Division of Cardiology, Daegu Catholic University Medical Center, Daegu, South
      Korea. [email protected]
LA  - eng
PT  - Comparative Study
PT  - Journal Article
PT  - Observational Study
PT  - Research Support, Non-U.S. Gov't
DEP - 20151015
PL  - England
TA  - Cardiovasc Diabetol
JT  - Cardiovascular diabetology
JID - 101147637
SB  - IM
MH  - Aged
MH  - Cohort Studies
MH  - Diabetes Mellitus, Type 2/*epidemiology
MH  - Dyslipidemias/epidemiology
MH  - Female
MH  - Humans
MH  - Incidence
MH  - Kaplan-Meier Estimate
MH  - Male
MH  - Middle Aged
MH  - *Mortality
MH  - Multivariate Analysis
MH  - Myocardial Infarction/*epidemiology
MH  - Obesity/*epidemiology
MH  - Proportional Hazards Models
MH  - Prospective Studies
MH  - *Registries
MH  - Republic of Korea/epidemiology
MH  - Stroke Volume
MH  - Survival Rate
MH  - Ventricular Dysfunction, Left/epidemiology
PMC - PMC4608118
OID - NLM: PMC4608118
EDAT- 2015/10/17 06:00
MHDA- 2016/07/09 06:00
CRDT- 2015/10/17 06:00
PHST- 2015/07/02 [received]
PHST- 2015/10/09 [accepted]
AID - 10.1186/s12933-015-0305-1 [doi]
AID - 10.1186/s12933-015-0305-1 [pii]
PST - epublish
SO  - Cardiovasc Diabetol. 2015 Oct 15;14:141. doi: 10.1186/s12933-015-0305-1.

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