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Benefit of statin therapy in patients with coronary spasm-induced acute myocardial infarction.

Abstract Coronary artery spasm is associated with vascular smooth muscle hyper-reactivity. Statins suppress coronary spasm by inhibiting the vascular smooth muscle contraction. However, it is unclear whether statin therapy benefits patients with coronary spasm-induced acute myocardial infarction (AMI).
PMID
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Authors

Mayor MeshTerms
Keywords

Coronary vasospasm

Myocardial infarction

Prognosis

Statin

Journal Title journal of cardiology
Publication Year Start
%A Piao, Zhe Hao; Jeong, Myung Ho; Li, Ying; Jin, Li; Kim, Hyun Kuk; Park, Keun-Ho; Sim, Doo Sun; Kim, Kye Hun; Hong, Young Joon; Park, HyungWook; Kim, Ju Han; Ahn, Youngkeun; Cho, Jeong Gwan; Park, Jong Chun; Kim, Young Jo; Cho, Myeong Chan; Kim, Chong Jin; Kim, Hyo-Soo
%A Other Korea Acute Myocardial Infarction Registry (KAMIR) Investigators
%T Benefit of statin therapy in patients with coronary spasm-induced acute myocardial infarction.
%J Journal of cardiology, vol. 68, no. 1, pp. 7-12
%D 07/2016
%V 68
%N 1
%M eng
%B Coronary artery spasm is associated with vascular smooth muscle hyper-reactivity. Statins suppress coronary spasm by inhibiting the vascular smooth muscle contraction. However, it is unclear whether statin therapy benefits patients with coronary spasm-induced acute myocardial infarction (AMI).
%P 7
%L 12
%Y 10.1016/j.jjcc.2015.09.013
%W PHY
%G AUTHOR
%R 2016.......68....7P

@Article{Piao2016,
author="Piao, Zhe Hao
and Jeong, Myung Ho
and Li, Ying
and Jin, Li
and Kim, Hyun Kuk
and Park, Keun-Ho
and Sim, Doo Sun
and Kim, Kye Hun
and Hong, Young Joon
and Park, HyungWook
and Kim, Ju Han
and Ahn, Youngkeun
and Cho, Jeong Gwan
and Park, Jong Chun
and Kim, Young Jo
and Cho, Myeong Chan
and Kim, Chong Jin
and Kim, Hyo-Soo
and {Other Korea Acute Myocardial Infarction Registry (KAMIR) Investigators}",
title="Benefit of statin therapy in patients with coronary spasm-induced acute myocardial infarction.",
journal="Journal of cardiology",
year="2016",
month="Jul",
day="14",
volume="68",
number="1",
pages="7--12",
abstract="Coronary artery spasm is associated with vascular smooth muscle hyper-reactivity. Statins suppress coronary spasm by inhibiting the vascular smooth muscle contraction. However, it is unclear whether statin therapy benefits patients with coronary spasm-induced acute myocardial infarction (AMI).",
issn="1876-4738",
doi="10.1016/j.jjcc.2015.09.013",
url="http://www.ncbi.nlm.nih.gov/pubmed/26584973",
language="eng"
}

%0 Journal Article
%T Benefit of statin therapy in patients with coronary spasm-induced acute myocardial infarction.
%A Piao, Zhe Hao
%A Jeong, Myung Ho
%A Li, Ying
%A Jin, Li
%A Kim, Hyun Kuk
%A Park, Keun-Ho
%A Sim, Doo Sun
%A Kim, Kye Hun
%A Hong, Young Joon
%A Park, HyungWook
%A Kim, Ju Han
%A Ahn, Youngkeun
%A Cho, Jeong Gwan
%A Park, Jong Chun
%A Kim, Young Jo
%A Cho, Myeong Chan
%A Kim, Chong Jin
%A Kim, Hyo-Soo
%A Other Korea Acute Myocardial Infarction Registry (KAMIR) Investigators
%J Journal of cardiology
%D 2016
%8 Jul 14
%V 68
%N 1
%@ 1876-4738
%G eng
%F Piao2016
%X Coronary artery spasm is associated with vascular smooth muscle hyper-reactivity. Statins suppress coronary spasm by inhibiting the vascular smooth muscle contraction. However, it is unclear whether statin therapy benefits patients with coronary spasm-induced acute myocardial infarction (AMI).
%U http://dx.doi.org/10.1016/j.jjcc.2015.09.013
%U http://www.ncbi.nlm.nih.gov/pubmed/26584973
%P 7-12

PT Journal
AU Piao, ZH
   Jeong, MH
   Li, Y
   Jin, L
   Kim, HK
   Park, K
   Sim, DS
   Kim, KH
   Hong, YJ
   Park, H
   Kim, JH
   Ahn, Y
   Cho, JG
   Park, JC
   Kim, YJ
   Cho, MC
   Kim, CJ
   Kim, H
AU Other Korea Acute Myocardial Infarction Registry (KAMIR) Investigators
TI Benefit of statin therapy in patients with coronary spasm-induced acute myocardial infarction.
SO Journal of cardiology
JI J Cardiol
PD Jul
PY 2016
BP 7
EP 12
VL 68
IS 1
DI 10.1016/j.jjcc.2015.09.013
LA eng
AB Coronary artery spasm is associated with vascular smooth muscle hyper-reactivity. Statins suppress coronary spasm by inhibiting the vascular smooth muscle contraction. However, it is unclear whether statin therapy benefits patients with coronary spasm-induced acute myocardial infarction (AMI).
ER

PMID- 26584973
OWN - NLM
STAT- In-Data-Review
DA  - 20160617
IS  - 1876-4738 (Electronic)
IS  - 0914-5087 (Linking)
VI  - 68
IP  - 1
DP  - 2016 Jul
TI  - Benefit of statin therapy in patients with coronary spasm-induced acute
      myocardial infarction.
PG  - 7-12
LID - 10.1016/j.jjcc.2015.09.013 [doi]
LID - S0914-5087(15)00307-X [pii]
AB  - BACKGROUND: Coronary artery spasm is associated with vascular smooth muscle
      hyper-reactivity. Statins suppress coronary spasm by inhibiting the vascular
      smooth muscle contraction. However, it is unclear whether statin therapy benefits
      patients with coronary spasm-induced acute myocardial infarction (AMI). METHODS
      AND RESULTS: We analyzed 501 (median age 57 years; male/female, 346/155) patients
      with coronary spasm-induced AMI with nonobstructive coronary arteries (stenosis
      severity <50%) from the Korea AMI Registry between November 2005 and October
      2013. They were divided into two groups according to statin prescription at
      discharge (statin group n=292; nonstatin group n=209). The primary endpoint was
      the composite of 12-month major adverse cardiac events, including all causes of
      death, non-fatal myocardial infarction, and target vessel revascularization. The 
      primary endpoint occurred in 17 patients during 12 months of follow-up. Statin
      therapy significantly reduced the risk of the composite primary endpoint
      [adjusted hazard ratio (HR): 0.30; 95% confidence interval (CI): 0.09-0.97;
      p=0.045]. Statin therapy reduced the risk of myocardial infarction (HR: 0.19; 95%
      CI: 0.04-0.93; p=0.040). However, we found no significant difference in the risk 
      of the composite of all-cause death. CONCLUSION: Statin therapy in patients with 
      coronary spasm-induced AMI with nonobstructive coronary arteries was associated
      with improved clinical outcome, which was predominantly accounted for by reducing
      the incidence of myocardial infarction.
CI  - Copyright (c) 2016. Published by Elsevier Ltd.
FAU - Piao, Zhe Hao
AU  - Piao ZH
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea; Jilin Hospital 
      Affiliated with Jilin University, Jilin, China.
FAU - Jeong, Myung Ho
AU  - Jeong MH
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea. Electronic
      address: [email protected]
FAU - Li, Ying
AU  - Li Y
AD  - Jilin Hospital Affiliated with Jilin University, Jilin, China.
FAU - Jin, Li
AU  - Jin L
AD  - Jilin Hospital Affiliated with Jilin University, Jilin, China.
FAU - Kim, Hyun Kuk
AU  - Kim HK
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea.
FAU - Park, Keun-Ho
AU  - Park KH
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea.
FAU - Sim, Doo Sun
AU  - Sim DS
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea.
FAU - Kim, Kye Hun
AU  - Kim KH
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea.
FAU - Hong, Young Joon
AU  - Hong YJ
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea.
FAU - Park, HyungWook
AU  - Park H
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea.
FAU - Kim, Ju Han
AU  - Kim JH
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea.
FAU - Ahn, Youngkeun
AU  - Ahn Y
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea.
FAU - Cho, Jeong Gwan
AU  - Cho JG
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea.
FAU - Park, Jong Chun
AU  - Park JC
AD  - Chonnam National University Hospital, Gwangju, Republic of Korea.
FAU - Kim, Young Jo
AU  - Kim YJ
AD  - Yeungnam University Hospital, Daegu, Republic of Korea.
FAU - Cho, Myeong Chan
AU  - Cho MC
AD  - Chungbuk National University Hospital, Cheongju, Republic of Korea.
FAU - Kim, Chong Jin
AU  - Kim CJ
AD  - Kyung Hee University Hospital, Seoul, Republic of Korea.
FAU - Kim, Hyo-Soo
AU  - Kim HS
AD  - Seoul National University Hospital, Seoul, Republic of Korea.
CN  - Other Korea Acute Myocardial Infarction Registry (KAMIR) Investigators
LA  - eng
PT  - Journal Article
DEP - 20151114
PL  - Netherlands
TA  - J Cardiol
JT  - Journal of cardiology
JID - 8804703
SB  - IM
OTO - NOTNLM
OT  - Coronary vasospasm
OT  - Myocardial infarction
OT  - Prognosis
OT  - Statin
EDAT- 2015/11/21 06:00
MHDA- 2015/11/21 06:00
CRDT- 2015/11/21 06:00
PHST- 2015/07/07 [received]
PHST- 2015/09/02 [revised]
PHST- 2015/09/17 [accepted]
PHST- 2015/11/14 [aheadofprint]
AID - S0914-5087(15)00307-X [pii]
AID - 10.1016/j.jjcc.2015.09.013 [doi]
PST - ppublish
SO  - J Cardiol. 2016 Jul;68(1):7-12. doi: 10.1016/j.jjcc.2015.09.013. Epub 2015 Nov
      14.
TY  - JOUR
AU  - Piao, Zhe Hao
AU  - Jeong, Myung Ho
AU  - Li, Ying
AU  - Jin, Li
AU  - Kim, Hyun Kuk
AU  - Park, Keun-Ho
AU  - Sim, Doo Sun
AU  - Kim, Kye Hun
AU  - Hong, Young Joon
AU  - Park, HyungWook
AU  - Kim, Ju Han
AU  - Ahn, Youngkeun
AU  - Cho, Jeong Gwan
AU  - Park, Jong Chun
AU  - Kim, Young Jo
AU  - Cho, Myeong Chan
AU  - Kim, Chong Jin
AU  - Kim, Hyo-Soo
AU  - Other Korea Acute Myocardial Infarction Registry (KAMIR) Investigators
PY  - 2016/Jul/14
TI  - Benefit of statin therapy in patients with coronary spasm-induced acute myocardial infarction.
T2  - J Cardiol
JO  - Journal of cardiology
SP  - 7
EP  - 12
VL  - 68
IS  - 1
N2  - Coronary artery spasm is associated with vascular smooth muscle hyper-reactivity. Statins suppress coronary spasm by inhibiting the vascular smooth muscle contraction. However, it is unclear whether statin therapy benefits patients with coronary spasm-induced acute myocardial infarction (AMI).
SN  - 1876-4738
UR  - http://dx.doi.org/10.1016/j.jjcc.2015.09.013
UR  - http://www.ncbi.nlm.nih.gov/pubmed/26584973
ID  - Piao2016
ER  - 
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