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Inflammatory Mediator Profiling of n-butanol Exposed Upper Airways in Individuals with Multiple Chemical Sensitivity.

Abstract Multiple Chemical Sensitivity (MCS) is a chronic condition characterized by reports of recurrent symptoms in response to low level exposure to various chemical substances. Recent findings suggests that dysregulation of the immune system may play a role in MCS pathophysiology.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title plos one
Publication Year Start




PMID- 26599866
OWN - NLM
STAT- MEDLINE
DA  - 20151125
DCOM- 20160620
LR  - 20151203
IS  - 1932-6203 (Electronic)
IS  - 1932-6203 (Linking)
VI  - 10
IP  - 11
DP  - 2015
TI  - Inflammatory Mediator Profiling of n-butanol Exposed Upper Airways in Individuals
      with Multiple Chemical Sensitivity.
PG  - e0143534
LID - 10.1371/journal.pone.0143534 [doi]
AB  - BACKGROUND: Multiple Chemical Sensitivity (MCS) is a chronic condition
      characterized by reports of recurrent symptoms in response to low level exposure 
      to various chemical substances. Recent findings suggests that dysregulation of
      the immune system may play a role in MCS pathophysiology. OBJECTIVES: The aim of 
      this study was to examine baseline and low dose n-butanol-induced upper airway
      inflammatory response profiles in MCS subjects versus healthy controls. METHOD:
      Eighteen participants with MCS and 18 age- and sex-matched healthy controls were 
      enrolled in the study. Epithelial lining fluid was collected from the nasal
      cavity at three time points: baseline, within 15 minutes after being exposed to
      3.7 ppm n-butanol in an exposure chamber and four hours after exposure
      termination. A total of 19 cytokines and chemokines were quantified. Furthermore,
      at baseline and during the exposure session, participants rated the perceived
      intensity, valence and levels of symptoms and autonomic recordings were obtained.
      RESULTS: The physiological and psychophysical measurements during the n-butanol
      exposure session verified a specific response in MCS individuals only. However,
      MCS subjects and healthy controls displayed similar upper airway inflammatory
      mediator profiles (P>0.05) at baseline. Likewise, direct comparison of mediator
      levels in the MCS group and controls after n-butanol exposure revealed no
      significant group differences. CONCLUSION: We demonstrate no abnormal upper
      airway inflammatory mediator levels in MCS subjects before or after a
      symptom-eliciting exposure to low dose n-butanol, implying that upper airways of 
      MCS subjects are functionally intact at the level of cytokine and chemokine
      production and secretory capacity. This suggests that previous findings of
      increased cytokine plasma levels in MCS are unlikely to be caused by systemic
      priming via excessive upper airway inflammatory processes.
FAU - Dantoft, Thomas Meinertz
AU  - Dantoft TM
AD  - Danish Research Centre for Chemical Sensitivities, Copenhagen University
      Hospital, Gentofte, Denmark.
AD  - Center for Biological Sequence Analysis, Department of Systems Biology, Technical
      University of Denmark, Kongens Lyngby, Denmark.
FAU - Skovbjerg, Sine
AU  - Skovbjerg S
AD  - Research Centre for Prevention and Health, Capital Region, Copenhagen, Denmark.
FAU - Andersson, Linus
AU  - Andersson L
AD  - Department of Psychology, Umea University, Umea, Sweden.
AD  - Department of Occupational and Public Health Sciences, University of Gavle, Umea,
      Sweden.
FAU - Claeson, Anna-Sara
AU  - Claeson AS
AD  - Department of Psychology, Umea University, Umea, Sweden.
FAU - Lind, Nina
AU  - Lind N
AD  - Department of Psychology, Umea University, Umea, Sweden.
FAU - Nordin, Steven
AU  - Nordin S
AD  - Department of Psychology, Umea University, Umea, Sweden.
FAU - Brix, Susanne
AU  - Brix S
AD  - Center for Biological Sequence Analysis, Department of Systems Biology, Technical
      University of Denmark, Kongens Lyngby, Denmark.
LA  - eng
PT  - Controlled Clinical Trial
PT  - Journal Article
PT  - Research Support, Non-U.S. Gov't
DEP - 20151123
PL  - United States
TA  - PLoS One
JT  - PloS one
JID - 101285081
RN  - 0 (Cytokines)
RN  - 8PJ61P6TS3 (1-Butanol)
SB  - IM
MH  - 1-Butanol/adverse effects/*immunology
MH  - Case-Control Studies
MH  - Cytokines/metabolism
MH  - Female
MH  - Humans
MH  - Inflammation/immunology/metabolism
MH  - Inhalation Exposure/adverse effects
MH  - Male
MH  - Multiple Chemical Sensitivity/*immunology/metabolism
MH  - Respiratory System/drug effects
PMC - PMC4657963
OID - NLM: PMC4657963
EDAT- 2015/11/26 06:00
MHDA- 2016/06/21 06:00
CRDT- 2015/11/25 06:00
PHST- 2015 [ecollection]
PHST- 2015/06/02 [received]
PHST- 2015/11/05 [accepted]
PHST- 2015/11/23 [epublish]
AID - 10.1371/journal.pone.0143534 [doi]
AID - PONE-D-15-23949 [pii]
PST - epublish
SO  - PLoS One. 2015 Nov 23;10(11):e0143534. doi: 10.1371/journal.pone.0143534.
      eCollection 2015.

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