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Assessment of glutathione peroxidase-1 polymorphisms, oxidative stress and DNA damage in sensitivity-related illnesses.

Abstract Oxidative stress increase is a key event for development of sensitivity-related illnesses (SRIs). The aim of this work was to evaluate the influence of a genetic variant in the antioxidant enzyme glutathione peroxidase (GPx1) on oxidative stress development in SRIs.
PMID
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Authors

Mayor MeshTerms

DNA Damage

Oxidative Stress

Polymorphism, Genetic

Keywords

Antioxidant enzyme polymorphisms

Comet assay

Erythrocyte glutathione

Idiopathic environmental intolerances

Impaired detoxification systems

Ubiquinone

Journal Title life sciences
Publication Year Start




PMID- 26685757
OWN - NLM
STAT- MEDLINE
DA  - 20160205
DCOM- 20160613
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 145
DP  - 2016 Jan 15
TI  - Assessment of glutathione peroxidase-1 polymorphisms, oxidative stress and DNA
      damage in sensitivity-related illnesses.
PG  - 27-33
LID - 10.1016/j.lfs.2015.12.028 [doi]
LID - S0024-3205(15)30121-1 [pii]
AB  - AIMS: Oxidative stress increase is a key event for development of
      sensitivity-related illnesses (SRIs). The aim of this work was to evaluate the
      influence of a genetic variant in the antioxidant enzyme glutathione peroxidase
      (GPx1) on oxidative stress development in SRIs. MAIN METHODS: GPx1 rs1800668
      genotype, as well as glutathione, ubiquinone, and DNA damage were assessed in 34 
      SRI patients and 36 healthy subjects. KEY FINDINGS: Total glutathione,
      reduced/oxidized glutathione, and ubiquinone were significantly decreased in
      cases compared with controls, while DNA fragmentation was significantly increased
      in patients. However, these differences were not associated to GPx1 genetic
      background. SIGNIFICANCE: GPx1 rs1800668 polymorphism does not play a major role 
      in SRI-related oxidative stress development.
CI  - Copyright (c) 2015 Elsevier Inc. All rights reserved.
FAU - Gugliandolo, Agnese
AU  - Gugliandolo A
AD  - Department of Biomedical and Dental Sciences and Morpho-functional Imaging,
      Polyclinic University of Messina, Via C. Valeria 1, 98125 Messina, Italy.
FAU - Gangemi, Chiara
AU  - Gangemi C
AD  - Department of Biomedical and Dental Sciences and Morpho-functional Imaging,
      Polyclinic University of Messina, Via C. Valeria 1, 98125 Messina, Italy.
FAU - Calabro, Carlo
AU  - Calabro C
AD  - Department of Biomedical and Dental Sciences and Morpho-functional Imaging,
      Polyclinic University of Messina, Via C. Valeria 1, 98125 Messina, Italy.
FAU - Vecchio, Mercurio
AU  - Vecchio M
AD  - Department of Biomedical and Dental Sciences and Morpho-functional Imaging,
      Polyclinic University of Messina, Via C. Valeria 1, 98125 Messina, Italy.
FAU - Di Mauro, Debora
AU  - Di Mauro D
AD  - Department of Biomedical and Dental Sciences and Morpho-functional Imaging,
      Polyclinic University of Messina, Via C. Valeria 1, 98125 Messina, Italy.
FAU - Renis, Marcella
AU  - Renis M
AD  - Department of Drug Sciences, University of Catania, Viale Andrea Doria, 95100
      Catania, Italy.
FAU - Ientile, Riccardo
AU  - Ientile R
AD  - Department of Biomedical and Dental Sciences and Morpho-functional Imaging,
      Polyclinic University of Messina, Via C. Valeria 1, 98125 Messina, Italy.
FAU - Curro, Monica
AU  - Curro M
AD  - Department of Biomedical and Dental Sciences and Morpho-functional Imaging,
      Polyclinic University of Messina, Via C. Valeria 1, 98125 Messina, Italy.
FAU - Caccamo, Daniela
AU  - Caccamo D
AD  - Department of Biomedical and Dental Sciences and Morpho-functional Imaging,
      Polyclinic University of Messina, Via C. Valeria 1, 98125 Messina, Italy.
      Electronic address: [email protected]
LA  - eng
PT  - Journal Article
DEP - 20151211
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - EC 1.11.1.- (glutathione peroxidase GPX1)
RN  - EC 1.11.1.9 (Glutathione Peroxidase)
SB  - IM
MH  - Adult
MH  - *DNA Damage
MH  - Female
MH  - Genotype
MH  - Glutathione Peroxidase/*genetics/metabolism
MH  - Humans
MH  - Male
MH  - Multiple Chemical Sensitivity/*genetics/metabolism
MH  - *Oxidative Stress
MH  - *Polymorphism, Genetic
MH  - Young Adult
OTO - NOTNLM
OT  - Antioxidant enzyme polymorphisms
OT  - Comet assay
OT  - Erythrocyte glutathione
OT  - Idiopathic environmental intolerances
OT  - Impaired detoxification systems
OT  - Ubiquinone
EDAT- 2015/12/22 06:00
MHDA- 2016/06/14 06:00
CRDT- 2015/12/22 06:00
PHST- 2015/09/17 [received]
PHST- 2015/11/12 [revised]
PHST- 2015/12/11 [accepted]
PHST- 2015/12/11 [aheadofprint]
AID - S0024-3205(15)30121-1 [pii]
AID - 10.1016/j.lfs.2015.12.028 [doi]
PST - ppublish
SO  - Life Sci. 2016 Jan 15;145:27-33. doi: 10.1016/j.lfs.2015.12.028. Epub 2015 Dec
      11.

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