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Application of Metabolomics to Multiple Chemical Sensitivity Research.

Abstract Multiple chemical sensitivity (MCS) is an acquired chronic disorder characterized by nonspecific symptoms in multiple organ systems associated with exposure to low-level chemicals. Diagnosis of MCS can be difficult because of the inability to assess the causal relationship between exposure and symptoms. No standardized objective measures for the identification of MCS and no precise definition of this disorder have been established. Recent technological advances in mass spectrometry have significantly improved our capacity to obtain more data from each biological sample. Metabolomics comprises the methods and techniques that are used to determine the small-level molecules in biofluids and tissues. The metabolomic profile-the metabolome-has multiple applications in many biological sciences, including the development of new diagnostic tools for medicine. We performed metabolomics to detect the difference between 9 patients with MCS and 9 controls. We identified 183 substances whose levels were beyond the normal detection limit. The most prominent differences included significant increases in the levels of both hexanoic acid and pelargonic acid, and also a significant decrease in the level of acetylcarnitine in patients with MCS. In conclusion, using metabolomics analysis, we uncovered a hitherto unrecognized alteration in the levels of metabolites in MCS. These changes may have important biological implications and may have a significant potential for use as biomarkers.
PMID
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Authors

Mayor MeshTerms

Metabolomics

Keywords
Journal Title nihon eiseigaku zasshi. japanese journal of hygiene
Publication Year Start




PMID- 26832623
OWN - NLM
STAT- MEDLINE
DA  - 20160202
DCOM- 20161027
LR  - 20161101
IS  - 1882-6482 (Electronic)
IS  - 0021-5082 (Linking)
VI  - 71
IP  - 1
DP  - 2016
TI  - [Application of Metabolomics to Multiple Chemical Sensitivity Research].
PG  - 94-9
LID - 10.1265/jjh.71.94 [doi]
AB  - Multiple chemical sensitivity (MCS) is an acquired chronic disorder characterized
      by nonspecific symptoms in multiple organ systems associated with exposure to
      low-level chemicals. Diagnosis of MCS can be difficult because of the inability
      to assess the causal relationship between exposure and symptoms. No standardized 
      objective measures for the identification of MCS and no precise definition of
      this disorder have been established. Recent technological advances in mass
      spectrometry have significantly improved our capacity to obtain more data from
      each biological sample. Metabolomics comprises the methods and techniques that
      are used to determine the small-level molecules in biofluids and tissues. The
      metabolomic profile-the metabolome-has multiple applications in many biological
      sciences, including the development of new diagnostic tools for medicine. We
      performed metabolomics to detect the difference between 9 patients with MCS and 9
      controls. We identified 183 substances whose levels were beyond the normal
      detection limit. The most prominent differences included significant increases in
      the levels of both hexanoic acid and pelargonic acid, and also a significant
      decrease in the level of acetylcarnitine in patients with MCS. In conclusion,
      using metabolomics analysis, we uncovered a hitherto unrecognized alteration in
      the levels of metabolites in MCS. These changes may have important biological
      implications and may have a significant potential for use as biomarkers.
FAU - Katoh, Takahiko
AU  - Katoh T
AD  - Department of Public Health, Faculty of Life Sciences, Kumamoto University.
FAU - Fujiwara, Yuki
AU  - Fujiwara Y
FAU - Nakashita, Chihiro
AU  - Nakashita C
FAU - Lu, Xi
AU  - Lu X
FAU - Hisada, Aya
AU  - Hisada A
FAU - Miyazaki, Wataru
AU  - Miyazaki W
FAU - Azuma, Kenichi
AU  - Azuma K
FAU - Tanigawa, Mari
AU  - Tanigawa M
FAU - Uchiyama, Iwao
AU  - Uchiyama I
FAU - Kunugita, Naoki
AU  - Kunugita N
LA  - JPN
PT  - Journal Article
PL  - Japan
TA  - Nihon Eiseigaku Zasshi
JT  - Nihon eiseigaku zasshi. Japanese journal of hygiene
JID - 0417457
RN  - 0 (Biomarkers)
RN  - 6DH1W9VH8Q (Acetylcarnitine)
SB  - IM
MH  - Acetylcarnitine/analysis
MH  - Biomarkers/blood
MH  - Female
MH  - Humans
MH  - *Metabolomics
MH  - Middle Aged
MH  - Multiple Chemical Sensitivity/*metabolism
EDAT- 2016/02/03 06:00
MHDA- 2016/11/01 06:00
CRDT- 2016/02/03 06:00
AID - 10.1265/jjh.71.94 [doi]
PST - ppublish
SO  - Nihon Eiseigaku Zasshi. 2016;71(1):94-9. doi: 10.1265/jjh.71.94.

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