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Intensity-modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial.

Abstract The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule.
PMID
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Authors

Mayor MeshTerms
Keywords

acute toxicity

conformal radiotherapy

intensity-modulated radiotherapy (IMRT)

late toxicity

prostate cancer

Journal Title cancer
Publication Year Start
%A Viani, Gustavo Arruda; Viana, Bruno Silveira; Martin, Jose Eduardo Chicareli; Rossi, Bruno Tiago; Zuliani, Gisele; Stefano, Eduardo Jose
%T Intensity-modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial.
%J Cancer, vol. 122, no. 13, pp. 2004-2011
%D 07/2016
%V 122
%N 13
%M eng
%B The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule.
%P 2004
%L 2011
%Y 10.1002/cncr.29983
%W PHY
%G AUTHOR
%R 2016CaRes.122.2004V

@Article{Viani2016,
author="Viani, Gustavo Arruda
and Viana, Bruno Silveira
and Martin, Jose Eduardo Chicareli
and Rossi, Bruno Tiago
and Zuliani, Gisele
and Stefano, Eduardo Jose",
title="Intensity-modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial.",
journal="Cancer",
year="2016",
month="Jul",
day="01",
volume="122",
number="13",
pages="2004--2011",
abstract="The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule.",
issn="1097-0142",
doi="10.1002/cncr.29983",
url="http://www.ncbi.nlm.nih.gov/pubmed/27028170",
language="eng"
}

%0 Journal Article
%T Intensity-modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial.
%A Viani, Gustavo Arruda
%A Viana, Bruno Silveira
%A Martin, Jose Eduardo Chicareli
%A Rossi, Bruno Tiago
%A Zuliani, Gisele
%A Stefano, Eduardo Jose
%J Cancer
%D 2016
%8 Jul 01
%V 122
%N 13
%@ 1097-0142
%G eng
%F Viani2016
%X The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule.
%U http://dx.doi.org/10.1002/cncr.29983
%U http://www.ncbi.nlm.nih.gov/pubmed/27028170
%P 2004-2011

PT Journal
AU Viani, GA
   Viana, BS
   Martin, JEC
   Rossi, BT
   Zuliani, G
   Stefano, EJ
TI Intensity-modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial.
SO Cancer
PD Jul
PY 2016
BP 2004
EP 2011
VL 122
IS 13
DI 10.1002/cncr.29983
LA eng
AB The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule.
ER

PMID- 27028170
OWN - NLM
STAT- In-Data-Review
DA  - 20160617
IS  - 1097-0142 (Electronic)
IS  - 0008-543X (Linking)
VI  - 122
IP  - 13
DP  - 2016 Jul 1
TI  - Intensity-modulated radiotherapy reduces toxicity with similar biochemical
      control compared with 3-dimensional conformal radiotherapy for prostate cancer: A
      randomized clinical trial.
PG  - 2004-11
LID - 10.1002/cncr.29983 [doi]
AB  - BACKGROUND: The objective of this article was to report the results from a
      randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 
      3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer 
      on a hypofractionated schedule. METHODS: The authors randomly assigned 215 men
      who had localized prostate cancer to receive hypofractionated radiotherapy to a
      total dose of 70 grays (Gy) in 25 fractions (at 2.8 Gy per fraction) using either
      IMRT or 3DCRT. Acute and late gastrointestinal (GI) and genitourinary (GU)
      toxicity were prospectively evaluated according to modified Radiation Therapy
      Oncology Group criteria. Biochemical control was defined according to the Phoenix
      criteria (prostate-specific antigen nadir + 2 ng/mL). RESULTS: In total, 215
      patients were enrolled in the IMRT group (n = 109) or the 3DCRT group (n = 106). 
      The 3DCRT arm had a 27% rate of grade >/= 2 acute GU toxicity compared with a 9% 
      rate in the IMRT arm (P = .001) and a 24% rate of grade >/= 2 acute GI toxicity
      compared with a 7% rate in the IMRT arm (P = .001). The maximal rate of grade
      >/=2 late GU toxicity during the entire period of follow-up was 3.7% in the IMRT 
      group versus 12.3% in the 3DCRT group (P = .02). The maximal rate of grade >/=2
      late GI toxicity during the entire follow-up was 6.4% in the IMRT group versus
      21.7% in the 3DCRT group (P = .001). The 5-year rate of freedom from biochemical 
      failure was 95.4% in the IMRT arm and 94.3% in the 3DCRT arm (P = .678).
      CONCLUSIONS: IMRT reduced the delivery of significant radiation doses to the
      bladder and rectum using a similar target volume. This dosimetric advantage
      resulted in a lower rate of acute/late grade >/= 2 GI and GU toxicity for IMRT
      compared with 3DCRT. Cancer 2016;122:2004-11. (c) 2016 American Cancer Society.
CI  - (c) 2016 American Cancer Society.
FAU - Viani, Gustavo Arruda
AU  - Viani GA
AD  - Department of Radiation Oncology, Marilia Medical School, Marilia, Sao Paulo,
      Brazil.
FAU - Viana, Bruno Silveira
AU  - Viana BS
AD  - Department of Radiation Oncology, Marilia Medical School, Marilia, Sao Paulo,
      Brazil.
FAU - Martin, Jose Eduardo Chicareli
AU  - Martin JE
AD  - Department of Radiation Oncology, Marilia Medical School, Marilia, Sao Paulo,
      Brazil.
FAU - Rossi, Bruno Tiago
AU  - Rossi BT
AD  - Department of Radiation Oncology, Marilia Medical School, Marilia, Sao Paulo,
      Brazil.
FAU - Zuliani, Gisele
AU  - Zuliani G
AD  - Department of Radiation Oncology, Marilia Medical School, Marilia, Sao Paulo,
      Brazil.
FAU - Stefano, Eduardo Jose
AU  - Stefano EJ
AD  - Department of Radiation Oncology, Marilia Medical School, Marilia, Sao Paulo,
      Brazil.
LA  - eng
PT  - Journal Article
DEP - 20160329
PL  - United States
TA  - Cancer
JT  - Cancer
JID - 0374236
SB  - AIM
SB  - IM
OTO - NOTNLM
OT  - acute toxicity
OT  - conformal radiotherapy
OT  - intensity-modulated radiotherapy (IMRT)
OT  - late toxicity
OT  - prostate cancer
EDAT- 2016/03/31 06:00
MHDA- 2016/03/31 06:00
CRDT- 2016/03/31 06:00
PHST- 2015/12/17 [received]
PHST- 2016/01/28 [revised]
PHST- 2016/02/01 [accepted]
PHST- 2016/03/29 [aheadofprint]
AID - 10.1002/cncr.29983 [doi]
PST - ppublish
SO  - Cancer. 2016 Jul 1;122(13):2004-11. doi: 10.1002/cncr.29983. Epub 2016 Mar 29.
TY  - JOUR
AU  - Viani, Gustavo Arruda
AU  - Viana, Bruno Silveira
AU  - Martin, Jose Eduardo Chicareli
AU  - Rossi, Bruno Tiago
AU  - Zuliani, Gisele
AU  - Stefano, Eduardo Jose
PY  - 2016/Jul/01
TI  - Intensity-modulated radiotherapy reduces toxicity with similar biochemical control compared with 3-dimensional conformal radiotherapy for prostate cancer: A randomized clinical trial.
JO  - Cancer
SP  - 2004
EP  - 2011
VL  - 122
IS  - 13
N2  - The objective of this article was to report the results from a randomized clinical trial comparing intensity-modulated radiotherapy (IMRT) with 3-dimensonal conformal radiotherapy (3DCRT) for the treatment of prostate cancer on a hypofractionated schedule.
SN  - 1097-0142
UR  - http://dx.doi.org/10.1002/cncr.29983
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27028170
ID  - Viani2016
ER  - 
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