close: Closure of patent foramen ovale, oral anticoagulants or antiplatelet therapy to prevent stroke recurrence: Study design. |
|
| Abstract | Currently available data do not provide definitive evidence on the comparative benefits of closure of patent foramen ovale, oral anticoagulants and antiplatelet therapy in patients with patent foramen ovale-associated cryptogenic stroke |
| PMID | 27056964 |
| Related Publications |
Closure of patent foramen ovale versus medical therapy after cryptogenic stroke. |
| Authors | |
| Mayor MeshTerms | |
| Keywords | |
| Journal Title | international journal of stroke : official journal of the international stroke society |
| Publication Year Start | 2016-01-01 |
%A Mas, Jean-Louis; Derumeaux, Genevi?ve; Amarenco, Pierre; Arquizan, Caroline; Aubry, Pierre; Barthelet, Martine; Bertrand, Bernard; Brochet, Eric; Cabanes, Laure; Donal, Erwan; Dubois-Rand?, Jean-Luc; Durand-Zaleski, Isabelle; Ernande, Laura; Finet, G?rard; Fraisse, Alain; Giroud, Maurice; Gu?rin, Patrice; Habib, Gilbert; Juliard, Jean-Michel; Leys, Didier; Li?vre, Michel; Lusson, Jean-Ren?; Marcon, Fran?ois; Michel, Patrick; Moulin, Thierry; Mounier-Vehier, Fran?ois; Pierard, Luc; Piot, Christophe; Rey, Christian; Rodier, Gilles; Roudaut, Raymond; Schleich, Jean-Marc; Teiger, Emmanuel; Turc, Guillaume; Vuillier, Fabrice; Weimar, Christian; Woimant, France; Chatellier, Gilles %A CLOSE investigators %T close: Closure of patent foramen ovale, oral anticoagulants or antiplatelet therapy to prevent stroke recurrence: Study design. %J International journal of stroke : official journal of the International Stroke Society, vol. 11, no. 6, pp. 724-732 %D 08/2016 %V 11 %N 6 %M eng %B Currently available data do not provide definitive evidence on the comparative benefits of closure of patent foramen ovale, oral anticoagulants and antiplatelet therapy in patients with patent foramen ovale-associated cryptogenic stroke %P 724 %L 732 %Y 10.1177/1747493016643551 %W PHY %G AUTHOR %R 2016.......11..724M
@Article{Mas2016,
author="Mas, Jean-Louis
and Derumeaux, Genevi{\`e}ve
and Amarenco, Pierre
and Arquizan, Caroline
and Aubry, Pierre
and Barthelet, Martine
and Bertrand, Bernard
and Brochet, Eric
and Cabanes, Laure
and Donal, Erwan
and Dubois-Rand{\'e}, Jean-Luc
and Durand-Zaleski, Isabelle
and Ernande, Laura
and Finet, G{\'e}rard
and Fraisse, Alain
and Giroud, Maurice
and Gu{\'e}rin, Patrice
and Habib, Gilbert
and Juliard, Jean-Michel
and Leys, Didier
and Li{\`e}vre, Michel
and Lusson, Jean-Ren{\'e}
and Marcon, Fran{\c{c}}ois
and Michel, Patrick
and Moulin, Thierry
and Mounier-Vehier, Fran{\c{c}}ois
and Pierard, Luc
and Piot, Christophe
and Rey, Christian
and Rodier, Gilles
and Roudaut, Raymond
and Schleich, Jean-Marc
and Teiger, Emmanuel
and Turc, Guillaume
and Vuillier, Fabrice
and Weimar, Christian
and Woimant, France
and Chatellier, Gilles
and {CLOSE investigators}",
title="close: Closure of patent foramen ovale, oral anticoagulants or antiplatelet therapy to prevent stroke recurrence: Study design.",
journal="International journal of stroke : official journal of the International Stroke Society",
year="2016",
month="Aug",
day="07",
volume="11",
number="6",
pages="724--732",
abstract="Currently available data do not provide definitive evidence on the comparative benefits of closure of patent foramen ovale, oral anticoagulants and antiplatelet therapy in patients with patent foramen ovale-associated cryptogenic stroke",
issn="1747-4949",
doi="10.1177/1747493016643551",
url="http://www.ncbi.nlm.nih.gov/pubmed/27056964",
language="eng"
}
%0 Journal Article %T close: Closure of patent foramen ovale, oral anticoagulants or antiplatelet therapy to prevent stroke recurrence: Study design. %A Mas, Jean-Louis %A Derumeaux, Genevi?ve %A Amarenco, Pierre %A Arquizan, Caroline %A Aubry, Pierre %A Barthelet, Martine %A Bertrand, Bernard %A Brochet, Eric %A Cabanes, Laure %A Donal, Erwan %A Dubois-Rand?, Jean-Luc %A Durand-Zaleski, Isabelle %A Ernande, Laura %A Finet, G?rard %A Fraisse, Alain %A Giroud, Maurice %A Gu?rin, Patrice %A Habib, Gilbert %A Juliard, Jean-Michel %A Leys, Didier %A Li?vre, Michel %A Lusson, Jean-Ren? %A Marcon, Fran?ois %A Michel, Patrick %A Moulin, Thierry %A Mounier-Vehier, Fran?ois %A Pierard, Luc %A Piot, Christophe %A Rey, Christian %A Rodier, Gilles %A Roudaut, Raymond %A Schleich, Jean-Marc %A Teiger, Emmanuel %A Turc, Guillaume %A Vuillier, Fabrice %A Weimar, Christian %A Woimant, France %A Chatellier, Gilles %A CLOSE investigators %J International journal of stroke : official journal of the International Stroke Society %D 2016 %8 Aug 07 %V 11 %N 6 %@ 1747-4949 %G eng %F Mas2016 %X Currently available data do not provide definitive evidence on the comparative benefits of closure of patent foramen ovale, oral anticoagulants and antiplatelet therapy in patients with patent foramen ovale-associated cryptogenic stroke %U http://dx.doi.org/10.1177/1747493016643551 %U http://www.ncbi.nlm.nih.gov/pubmed/27056964 %P 724-732
PT Journal AU Mas, J Derumeaux, G Amarenco, P Arquizan, C Aubry, P Barthelet, M Bertrand, B Brochet, E Cabanes, L Donal, E Dubois-Rand?, J Durand-Zaleski, I Ernande, L Finet, G Fraisse, A Giroud, M Gu?rin, P Habib, G Juliard, J Leys, D Li?vre, M Lusson, J Marcon, F Michel, P Moulin, T Mounier-Vehier, F Pierard, L Piot, C Rey, C Rodier, G Roudaut, R Schleich, J Teiger, E Turc, G Vuillier, F Weimar, C Woimant, F Chatellier, G AU CLOSE investigators TI close: Closure of patent foramen ovale, oral anticoagulants or antiplatelet therapy to prevent stroke recurrence: Study design. SO International journal of stroke : official journal of the International Stroke Society JI Int J Stroke PD Aug PY 2016 BP 724 EP 732 VL 11 IS 6 DI 10.1177/1747493016643551 LA eng AB Currently available data do not provide definitive evidence on the comparative benefits of closure of patent foramen ovale, oral anticoagulants and antiplatelet therapy in patients with patent foramen ovale-associated cryptogenic stroke ER
PMID- 27056964
OWN - NLM
STAT- In-Data-Review
DA - 20160727
IS - 1747-4949 (Electronic)
IS - 1747-4930 (Linking)
VI - 11
IP - 6
DP - 2016 Aug
TI - close: Closure of patent foramen ovale, oral anticoagulants or antiplatelet
therapy to prevent stroke recurrence: Study design.
PG - 724-32
LID - 10.1177/1747493016643551 [doi]
AB - RATIONALE: Currently available data do not provide definitive evidence on the
comparative benefits of closure of patent foramen ovale, oral anticoagulants and
antiplatelet therapy in patients with patent foramen ovale-associated cryptogenic
stroke AIM: To assess whether transcatheter patent foramen ovale closure plus
antiplatelet therapy is superior to antiplatelet therapy alone and whether oral
anticoagulant therapy is superior to antiplatelet therapy, for secondary stroke
prevention in patients aged 16 to 60 years with a large patent foramen ovale or a
patent foramen ovale associated with an atrial septal aneurysm, and an otherwise
unexplained ischaemic stroke or retinal ischaemia. SAMPLE SIZE: Six hundred and
sixty-four patients were included in the study. METHODS AND DESIGN: CLOSE is an
academic-driven, multicentre, randomized, open-label, three-group, superiority
trial with blinded adjudication of outcome events. The trial has been registered
with Clinical Trials Register (Clinicaltrials.gov, NCT00562289). Patient
recruitment started in December 2007. Patient follow-up will continue until
December 2016. Expected mean follow-up = 5.6 years. STUDY OUTCOMES: The primary
efficacy outcome is the occurrence of fatal or nonfatal stroke. Safety outcomes
include fatal, life-threatening or major procedure- or device-related
complications and fatal, life-threatening or major haemorrhagic complications.
DISCUSSION: CLOSE is the first specifically designed trial to assess the
superiority of patent foramen ovale closure over antiplatelet therapy alone and
the superiority of oral anticoagulants over antiplatelet therapy to prevent
stroke recurrence in patients with patent foramen ovale-associated cryptogenic
stroke.
CI - (c) 2016 World Stroke Organization.
FAU - Mas, Jean-Louis
AU - Mas JL
AD - Department of Neurology, Sainte-Anne Hospital, Paris Descartes University, Inserm
894, DHU NeuroVasc, Paris, France [email protected]
FAU - Derumeaux, Genevieve
AU - Derumeaux G
AD - Department of Physiology, Henri Mondor Hospital, Paris Est Creteil University,
Inserm 955, DHU ATVB, Creteil, France.
FAU - Amarenco, Pierre
AU - Amarenco P
AD - APHP, Department of Neurology and Stroke Center, Bichat Hospital, Paris-Diderot
University, Inserm 1148, DHU FIRE, Paris, France.
FAU - Arquizan, Caroline
AU - Arquizan C
AD - Department of Neurology, Gui de Chauliac Hospital, Montpellier, France.
FAU - Aubry, Pierre
AU - Aubry P
AD - APHP, Department of Cardiology, Bichat Hospital, Paris Diderot University, Inserm
1148, DHU FIRE, Paris, France.
FAU - Barthelet, Martine
AU - Barthelet M
AD - Department of Cardiovascular Investigations, Louis Pradel Hospital, Lyon
University, Bron, France.
FAU - Bertrand, Bernard
AU - Bertrand B
AD - Department of Cardiology, CHU A. Michallon, Joseph Fourier University, Grenoble,
France.
FAU - Brochet, Eric
AU - Brochet E
AD - APHP, Department of Cardiology, Bichat Hospital, Paris Diderot University, Inserm
1148, DHU FIRE, Paris, France.
FAU - Cabanes, Laure
AU - Cabanes L
AD - AP-HP, Department of Cardiology, Cochin Hospital, Paris-Descartes University,
Paris, France.
FAU - Donal, Erwan
AU - Donal E
AD - Department of Cardiology and Vascular Diseases, Pontchaillou Hospital, Rennes
University, Rennes, France.
FAU - Dubois-Rande, Jean-Luc
AU - Dubois-Rande JL
AD - APHP, Department of Cardiology, Henri-Mondor Hospital, Paris Est Creteil
University, Inserm 955, DHU ATVB, Creteil, France.
FAU - Durand-Zaleski, Isabelle
AU - Durand-Zaleski I
AD - AP-HP, Department of Public Health, Henri Mondor Hospital, Paris Est Creteil
University, Creteil, France.
FAU - Ernande, Laura
AU - Ernande L
AD - Department of Physiology, Henri Mondor Hospital, Paris Est Creteil University,
Inserm 955, DHU ATVB, Creteil, France.
FAU - Finet, Gerard
AU - Finet G
AD - Department of Cardiology, Cardiovascular Hospital, Claude Bernard University,
Inserm 1060, Lyon, France.
FAU - Fraisse, Alain
AU - Fraisse A
AD - Department of Pediatric Cardiology, La Timone Hospital, Aix-Marseille Universite,
Marseille, France.
FAU - Giroud, Maurice
AU - Giroud M
AD - Department of Neurology, CHU Dijon, Bourgogne University, Dijon Stroke Registry,
Dijon France.
FAU - Guerin, Patrice
AU - Guerin P
AD - Department of Cardiology, Institut du Thorax, CHU Nantes, Nantes, France.
FAU - Habib, Gilbert
AU - Habib G
AD - Department of Cardiology, La Timone Hospital, Aix-Marseille Universite, Marseille
France.
FAU - Juliard, Jean-Michel
AU - Juliard JM
AD - APHP, Department of Cardiology, Bichat Hospital, Paris Diderot University, Inserm
1148, DHU FIRE, Paris, France.
FAU - Leys, Didier
AU - Leys D
AD - Department of Neurology and Stroke Unit, Roger Salengro Hospital, Lille 2
University, Inserm 1171, Lille, France.
FAU - Lievre, Michel
AU - Lievre M
AD - UMR CNRS 5558, Lyon 1 University, Lyon, France.
FAU - Lusson, Jean-Rene
AU - Lusson JR
AD - Department of Cardiology and Vascular Diseases, Gabriel Montpied Hospital,
Auvergne University, UMR 6284 Clermont-Ferrand, France.
FAU - Marcon, Francois
AU - Marcon F
AD - Department of Cardiovascular Diseases, Pediatric Cardiology Unit, Nancy
University, Nancy, France.
FAU - Michel, Patrick
AU - Michel P
AD - Stroke Center, Department of Neurology, Centre Hospitalier Universitaire Vaudois
and Lausanne University, Lausanne, Switzerland.
FAU - Moulin, Thierry
AU - Moulin T
AD - Department of Neurology, CHU Besancon, Franche-Comte University, CIC 1431,
Besancon, France.
FAU - Mounier-Vehier, Francois
AU - Mounier-Vehier F
AD - Department of Neurology, Doctor Schaffner Hospital, Lens, France.
FAU - Pierard, Luc
AU - Pierard L
AD - Department of Cardiology, Sart Tilman Hospital, Liege University, Liege, Belgium.
FAU - Piot, Christophe
AU - Piot C
AD - Department of Interventional Cardiology, Clinique du Millenaire, Montpellier
University, UMR 5203, Montpellier, France.
FAU - Rey, Christian
AU - Rey C
AD - Department of Pediatric Cardiology, Cardiology Hospital, Lille 2 University,
Lille, France.
FAU - Rodier, Gilles
AU - Rodier G
AD - Department of Neurology, Annecy-Genevois Hospital, Annecy, France.
FAU - Roudaut, Raymond
AU - Roudaut R
AD - Department of Cardiology and Vascular Diseases, Haut Leveque Hospital, Bordeaux
University, Bordeaux, France.
FAU - Schleich, Jean-Marc
AU - Schleich JM
AD - Department of Cardiology and Vascular Diseases, Pontchaillou Hospital, Rennes
University, Rennes, France.
FAU - Teiger, Emmanuel
AU - Teiger E
AD - Department of Physiology, Henri Mondor Hospital, Paris Est Creteil University,
Inserm 955, DHU ATVB, Creteil, France.
FAU - Turc, Guillaume
AU - Turc G
AD - Department of Neurology, Sainte-Anne Hospital, Paris Descartes University, Inserm
894, DHU NeuroVasc, Paris, France.
FAU - Vuillier, Fabrice
AU - Vuillier F
AD - Department of Neurology, CHU Besancon, Franche-Comte University, CIC 1431,
Besancon, France.
FAU - Weimar, Christian
AU - Weimar C
AD - Department of Neurology, University Hospital, University of Duisburg-Essen,
Essen, Germany.
FAU - Woimant, France
AU - Woimant F
AD - APHP, Department of Neurology, Lariboisiere Hospital, Agence Regionale de Sante
Ile-de-France, Paris, France.
FAU - Chatellier, Gilles
AU - Chatellier G
AD - APHP, Epidemiology and Clinical Research Unit, Georges Pompidou European
hospital, Paris Descartes University, Paris, France.
CN - CLOSE investigators
LA - eng
PT - Journal Article
DEP - 20160407
PL - United States
TA - Int J Stroke
JT - International journal of stroke : official journal of the International Stroke
Society
JID - 101274068
SB - IM
OTO - NOTNLM
OT - Ischaemic stroke
OT - antiplatelet therapy
OT - oral anticoagulants
OT - patent foramen ovale
OT - transcatheter PFO closure
EDAT- 2016/04/09 06:00
MHDA- 2016/04/09 06:00
CRDT- 2016/04/09 06:00
PHST- 2016/01/14 [received]
PHST- 2016/03/13 [accepted]
PHST- 2016/04/07 [aheadofprint]
AID - 1747493016643551 [pii]
AID - 10.1177/1747493016643551 [doi]
PST - ppublish
SO - Int J Stroke. 2016 Aug;11(6):724-32. doi: 10.1177/1747493016643551. Epub 2016 Apr
7.
TY - JOUR AU - Mas, Jean-Louis AU - Derumeaux, Genevi?ve AU - Amarenco, Pierre AU - Arquizan, Caroline AU - Aubry, Pierre AU - Barthelet, Martine AU - Bertrand, Bernard AU - Brochet, Eric AU - Cabanes, Laure AU - Donal, Erwan AU - Dubois-Rand?, Jean-Luc AU - Durand-Zaleski, Isabelle AU - Ernande, Laura AU - Finet, G?rard AU - Fraisse, Alain AU - Giroud, Maurice AU - Gu?rin, Patrice AU - Habib, Gilbert AU - Juliard, Jean-Michel AU - Leys, Didier AU - Li?vre, Michel AU - Lusson, Jean-Ren? AU - Marcon, Fran?ois AU - Michel, Patrick AU - Moulin, Thierry AU - Mounier-Vehier, Fran?ois AU - Pierard, Luc AU - Piot, Christophe AU - Rey, Christian AU - Rodier, Gilles AU - Roudaut, Raymond AU - Schleich, Jean-Marc AU - Teiger, Emmanuel AU - Turc, Guillaume AU - Vuillier, Fabrice AU - Weimar, Christian AU - Woimant, France AU - Chatellier, Gilles AU - CLOSE investigators PY - 2016/Aug/07 TI - close: Closure of patent foramen ovale, oral anticoagulants or antiplatelet therapy to prevent stroke recurrence: Study design. T2 - Int J Stroke JO - International journal of stroke : official journal of the International Stroke Society SP - 724 EP - 732 VL - 11 IS - 6 N2 - Currently available data do not provide definitive evidence on the comparative benefits of closure of patent foramen ovale, oral anticoagulants and antiplatelet therapy in patients with patent foramen ovale-associated cryptogenic stroke SN - 1747-4949 UR - http://dx.doi.org/10.1177/1747493016643551 UR - http://www.ncbi.nlm.nih.gov/pubmed/27056964 ID - Mas2016 ER -
<?xml version="1.0" encoding="UTF-8"?> <b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" > <b:Source> <b:Tag>Mas2016</b:Tag> <b:SourceType>ArticleInAPeriodical</b:SourceType> <b:Year>2016</b:Year> <b:Month>Aug</b:Month> <b:Day>07</b:Day> <b:PeriodicalName>International journal of stroke : official journal of the International Stroke Society</b:PeriodicalName> <b:Volume>11</b:Volume> <b:Issue>6</b:Issue> <b:Pages>724-732</b:Pages> <b:Author> <b:Author><b:NameList> <b:Person><b:Last>Mas</b:Last><b:First>Jean-Louis</b:First></b:Person> <b:Person><b:Last>Derumeaux</b:Last><b:First>Geneviève</b:First></b:Person> <b:Person><b:Last>Amarenco</b:Last><b:First>Pierre</b:First></b:Person> <b:Person><b:Last>Arquizan</b:Last><b:First>Caroline</b:First></b:Person> <b:Person><b:Last>Aubry</b:Last><b:First>Pierre</b:First></b:Person> <b:Person><b:Last>Barthelet</b:Last><b:First>Martine</b:First></b:Person> <b:Person><b:Last>Bertrand</b:Last><b:First>Bernard</b:First></b:Person> <b:Person><b:Last>Brochet</b:Last><b:First>Eric</b:First></b:Person> <b:Person><b:Last>Cabanes</b:Last><b:First>Laure</b:First></b:Person> <b:Person><b:Last>Donal</b:Last><b:First>Erwan</b:First></b:Person> <b:Person><b:Last>Dubois-Randé</b:Last><b:First>Jean-Luc</b:First></b:Person> <b:Person><b:Last>Durand-Zaleski</b:Last><b:First>Isabelle</b:First></b:Person> <b:Person><b:Last>Ernande</b:Last><b:First>Laura</b:First></b:Person> <b:Person><b:Last>Finet</b:Last><b:First>Gérard</b:First></b:Person> <b:Person><b:Last>Fraisse</b:Last><b:First>Alain</b:First></b:Person> <b:Person><b:Last>Giroud</b:Last><b:First>Maurice</b:First></b:Person> <b:Person><b:Last>Guérin</b:Last><b:First>Patrice</b:First></b:Person> <b:Person><b:Last>Habib</b:Last><b:First>Gilbert</b:First></b:Person> <b:Person><b:Last>Juliard</b:Last><b:First>Jean-Michel</b:First></b:Person> <b:Person><b:Last>Leys</b:Last><b:First>Didier</b:First></b:Person> <b:Person><b:Last>Lièvre</b:Last><b:First>Michel</b:First></b:Person> <b:Person><b:Last>Lusson</b:Last><b:First>Jean-René</b:First></b:Person> <b:Person><b:Last>Marcon</b:Last><b:First>François</b:First></b:Person> <b:Person><b:Last>Michel</b:Last><b:First>Patrick</b:First></b:Person> <b:Person><b:Last>Moulin</b:Last><b:First>Thierry</b:First></b:Person> <b:Person><b:Last>Mounier-Vehier</b:Last><b:First>François</b:First></b:Person> <b:Person><b:Last>Pierard</b:Last><b:First>Luc</b:First></b:Person> <b:Person><b:Last>Piot</b:Last><b:First>Christophe</b:First></b:Person> <b:Person><b:Last>Rey</b:Last><b:First>Christian</b:First></b:Person> <b:Person><b:Last>Rodier</b:Last><b:First>Gilles</b:First></b:Person> <b:Person><b:Last>Roudaut</b:Last><b:First>Raymond</b:First></b:Person> <b:Person><b:Last>Schleich</b:Last><b:First>Jean-Marc</b:First></b:Person> <b:Person><b:Last>Teiger</b:Last><b:First>Emmanuel</b:First></b:Person> <b:Person><b:Last>Turc</b:Last><b:First>Guillaume</b:First></b:Person> <b:Person><b:Last>Vuillier</b:Last><b:First>Fabrice</b:First></b:Person> <b:Person><b:Last>Weimar</b:Last><b:First>Christian</b:First></b:Person> <b:Person><b:Last>Woimant</b:Last><b:First>France</b:First></b:Person> <b:Person><b:Last>Chatellier</b:Last><b:First>Gilles</b:First></b:Person> <b:Person><b:Last>CLOSE investigators</b:Last></b:Person> </b:NameList></b:Author> </b:Author> <b:Title>close: Closure of patent foramen ovale, oral anticoagulants or antiplatelet therapy to prevent stroke recurrence: Study design.</b:Title> <b:ShortTitle>Int J Stroke</b:ShortTitle> <b:Comments>Currently available data do not provide definitive evidence on the comparative benefits of closure of patent foramen ovale, oral anticoagulants and antiplatelet therapy in patients with patent foramen ovale-associated cryptogenic stroke</b:Comments> </b:Source> </b:Sources>