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Long-Term Follow-Up in Patients With Airway Chemical Intolerance.

Abstract A 5-year follow-up study showed that a group of patients with airway symptoms from chemicals and scents had lasting symptoms, together with enduring increased capsaicin cough sensitivity. The aim was to follow up the same patients after another 5 years.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title journal of occupational and environmental medicine
Publication Year Start




PMID- 27058484
OWN - NLM
STAT- MEDLINE
DA  - 20160409
DCOM- 20170118
LR  - 20170118
IS  - 1536-5948 (Electronic)
IS  - 1076-2752 (Linking)
VI  - 58
IP  - 4
DP  - 2016 Apr
TI  - Long-Term Follow-Up in Patients With Airway Chemical Intolerance.
PG  - 421-6
LID - 10.1097/JOM.0000000000000695 [doi]
AB  - OBJECTIVE: A 5-year follow-up study showed that a group of patients with airway
      symptoms from chemicals and scents had lasting symptoms, together with enduring
      increased capsaicin cough sensitivity. The aim was to follow up the same patients
      after another 5 years. METHODS: All previously participants were invited for an
      additional follow-up. They visited the clinic twice; at one opportunity, they
      undertook a capsaicin inhalation provocation, and at the other, a methacholine
      provocation, and answered various questionnaires. RESULTS: Sixteen patients
      attende the study after a median of 8 years. They reported unchanged symptoms
      from chemicals and scents; the capsaicin cough sensitivity was still increased,
      and the repeatability for the capsaicin inhalation was good. CONCLUSIONS: Airway 
      symptoms induced by chemicals and scents constitute a chronic disease, with
      unchanged trigger factors, persistent symptoms, and unchanged, long-lasting
      sensory hyperreactivity.All procedures performed in studies involving human
      participants were in accordance with the ethical standards of the institutional
      and/or national research committee and with the 1964 Helsinki declaration and its
      later amendments or comparable ethical standards.This study was supported by
      grants from the Herman Krefting Foundation Against Asthma/Allergy, the Swedish
      Heart and Lung Foundation, and the Swedish Cancer and Allergy Fund.
FAU - Ternesten-Hasseus, Ewa
AU  - Ternesten-Hasseus E
AD  - Department of Respiratory Medicine and Allergology, Institution of Medicine, The 
      Sahlgrenska Academy at University of Gothenburg, Sweden.
LA  - eng
PT  - Journal Article
PL  - United States
TA  - J Occup Environ Med
JT  - Journal of occupational and environmental medicine
JID - 9504688
RN  - 0 (Perfume)
RN  - 0W5ETF9M2K (Methacholine Chloride)
RN  - S07O44R1ZM (Capsaicin)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Bronchial Provocation Tests
MH  - Capsaicin/pharmacology
MH  - Chronic Disease
MH  - Cough/chemically induced
MH  - Dose-Response Relationship, Drug
MH  - Female
MH  - Follow-Up Studies
MH  - Forced Expiratory Volume
MH  - Humans
MH  - Male
MH  - Methacholine Chloride/pharmacology
MH  - Middle Aged
MH  - Multiple Chemical Sensitivity/etiology/*physiopathology
MH  - Perfume/adverse effects
MH  - Respiratory Hypersensitivity/chemically induced/*physiopathology
MH  - Skin Tests
MH  - Surveys and Questionnaires
MH  - Time Factors
EDAT- 2016/04/09 06:00
MHDA- 2017/01/19 06:00
CRDT- 2016/04/09 06:00
AID - 10.1097/JOM.0000000000000695 [doi]
AID - 00043764-201604000-00016 [pii]
PST - ppublish
SO  - J Occup Environ Med. 2016 Apr;58(4):421-6. doi: 10.1097/JOM.0000000000000695.

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