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Significance of mast cell renal infiltration in patients with anti-GBM nephritis.

Abstract To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs?<50?mm(-2), n?=?18) and group 2 (MCs??50?mm(-2), n?=?20) according to the infiltrating renal MC count. The clinical-pathological indices were compared. And, correlation between MCs and the clinical-pathological indices was analyzed. Patients of group 2 had more severe renal dysfunctions, expressed as higher levels of serum creatinine (SCr 8.95???3.66 vs. 4.75???2.73?mg/dL, p?<?0.001), urine retinol-binding protein (RBP 29.8???13.9 vs. 15.7???11.5?mg/dL, p?=?0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7???21.9 vs. 47.0???33.6%, p?=?0.037) but a lower percentage of cellular crescents. More CD8 (268?mm(-2) vs. 180?mm(-2), p?=?0.045) and CD68 (268?mm(-2) vs. 180?mm(-2), p?=?0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes.
PMID
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Authors

Mayor MeshTerms
Keywords

Anti-GBM nephritis

chronic inflammation

chronic lesions

mast cells

renal function

Journal Title renal failure
Publication Year Start
%A Wu, Xiao-Mei; Zhang, Yi-Yan; Zhang, Ming-Chao; Zhang, Li-Hua; Zeng, Cai-Hong; Liu, Zhi-Hong; Tang, Zheng
%T Significance of mast cell renal infiltration in patients with anti-GBM nephritis.
%J Renal failure, vol. 38, no. 6, pp. 906-913
%D 07/2016
%V 38
%N 6
%M eng
%B To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs?<50?mm(-2), n?=?18) and group 2 (MCs??50?mm(-2), n?=?20) according to the infiltrating renal MC count. The clinical-pathological indices were compared. And, correlation between MCs and the clinical-pathological indices was analyzed. Patients of group 2 had more severe renal dysfunctions, expressed as higher levels of serum creatinine (SCr 8.95???3.66 vs. 4.75???2.73?mg/dL, p?<?0.001), urine retinol-binding protein (RBP 29.8???13.9 vs. 15.7???11.5?mg/dL, p?=?0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7???21.9 vs. 47.0???33.6%, p?=?0.037) but a lower percentage of cellular crescents. More CD8 (268?mm(-2) vs. 180?mm(-2), p?=?0.045) and CD68 (268?mm(-2) vs. 180?mm(-2), p?=?0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes.
%P 906
%L 913
%Y 10.3109/0886022X.2016.1164184
%W PHY
%G AUTHOR
%R 2016.......38..906W

@Article{Wu2016,
author="Wu, Xiao-Mei
and Zhang, Yi-Yan
and Zhang, Ming-Chao
and Zhang, Li-Hua
and Zeng, Cai-Hong
and Liu, Zhi-Hong
and Tang, Zheng",
title="Significance of mast cell renal infiltration in patients with anti-GBM nephritis.",
journal="Renal failure",
year="2016",
month="Jul",
day="20",
volume="38",
number="6",
pages="906--913",
abstract="To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs\thinspace<50\thinspacemm(-2), n\thinspace=\thinspace18) and group 2 (MCs\thinspace?50\thinspacemm(-2), n\thinspace=\thinspace20) according to the infiltrating renal MC count. The clinical-pathological indices were compared. And, correlation between MCs and the clinical-pathological indices was analyzed. Patients of group 2 had more severe renal dysfunctions, expressed as higher levels of serum creatinine (SCr 8.95\thinspace{\textpm}\thinspace3.66 vs. 4.75\thinspace{\textpm}\thinspace2.73\thinspacemg/dL, p\thinspace<\thinspace0.001), urine retinol-binding protein (RBP 29.8\thinspace{\textpm}\thinspace13.9 vs. 15.7\thinspace{\textpm}\thinspace11.5\thinspacemg/dL, p\thinspace=\thinspace0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7\thinspace{\textpm}\thinspace21.9 vs. 47.0\thinspace{\textpm}\thinspace33.6\%, p\thinspace=\thinspace0.037) but a lower percentage of cellular crescents. More CD8 (268\thinspacemm(-2) vs. 180\thinspacemm(-2), p\thinspace=\thinspace0.045) and CD68 (268\thinspacemm(-2) vs. 180\thinspacemm(-2), p\thinspace=\thinspace0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes.",
issn="1525-6049",
doi="10.3109/0886022X.2016.1164184",
url="http://www.ncbi.nlm.nih.gov/pubmed/27095326",
language="eng"
}

%0 Journal Article
%T Significance of mast cell renal infiltration in patients with anti-GBM nephritis.
%A Wu, Xiao-Mei
%A Zhang, Yi-Yan
%A Zhang, Ming-Chao
%A Zhang, Li-Hua
%A Zeng, Cai-Hong
%A Liu, Zhi-Hong
%A Tang, Zheng
%J Renal failure
%D 2016
%8 Jul 20
%V 38
%N 6
%@ 1525-6049
%G eng
%F Wu2016
%X To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs?<50?mm(-2), n?=?18) and group 2 (MCs??50?mm(-2), n?=?20) according to the infiltrating renal MC count. The clinical-pathological indices were compared. And, correlation between MCs and the clinical-pathological indices was analyzed. Patients of group 2 had more severe renal dysfunctions, expressed as higher levels of serum creatinine (SCr 8.95???3.66 vs. 4.75???2.73?mg/dL, p?<?0.001), urine retinol-binding protein (RBP 29.8???13.9 vs. 15.7???11.5?mg/dL, p?=?0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7???21.9 vs. 47.0???33.6%, p?=?0.037) but a lower percentage of cellular crescents. More CD8 (268?mm(-2) vs. 180?mm(-2), p?=?0.045) and CD68 (268?mm(-2) vs. 180?mm(-2), p?=?0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes.
%U http://dx.doi.org/10.3109/0886022X.2016.1164184
%U http://www.ncbi.nlm.nih.gov/pubmed/27095326
%P 906-913

PT Journal
AU Wu, X
   Zhang, Y
   Zhang, M
   Zhang, L
   Zeng, C
   Liu, Z
   Tang, Z
TI Significance of mast cell renal infiltration in patients with anti-GBM nephritis.
SO Renal failure
JI Ren Fail
PD Jul
PY 2016
BP 906
EP 913
VL 38
IS 6
DI 10.3109/0886022X.2016.1164184
LA eng
AB To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs?<50?mm(-2), n?=?18) and group 2 (MCs??50?mm(-2), n?=?20) according to the infiltrating renal MC count. The clinical-pathological indices were compared. And, correlation between MCs and the clinical-pathological indices was analyzed. Patients of group 2 had more severe renal dysfunctions, expressed as higher levels of serum creatinine (SCr 8.95???3.66 vs. 4.75???2.73?mg/dL, p?<?0.001), urine retinol-binding protein (RBP 29.8???13.9 vs. 15.7???11.5?mg/dL, p?=?0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7???21.9 vs. 47.0???33.6%, p?=?0.037) but a lower percentage of cellular crescents. More CD8 (268?mm(-2) vs. 180?mm(-2), p?=?0.045) and CD68 (268?mm(-2) vs. 180?mm(-2), p?=?0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes.
ER

PMID- 27095326
OWN - NLM
STAT- In-Data-Review
DA  - 20160625
IS  - 1525-6049 (Electronic)
IS  - 0886-022X (Linking)
VI  - 38
IP  - 6
DP  - 2016 Jul
TI  - Significance of mast cell renal infiltration in patients with anti-GBM nephritis.
PG  - 906-13
LID - 10.3109/0886022X.2016.1164184 [doi]
AB  - To investigate the role of mast cells (MCs) renal infiltration in the progression
      of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were
      enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to
      detect MCs in renal tissues. Patients were divided into group 1 (MCs &lt;50 mm(-2), 
      n = 18) and group 2 (MCs &gt;/=50 mm(-2), n = 20) according to the infiltrating
      renal MC count. The clinical-pathological indices were compared. And, correlation
      between MCs and the clinical-pathological indices was analyzed. Patients of group
      2 had more severe renal dysfunctions, expressed as higher levels of serum
      creatinine (SCr 8.95 +/- 3.66 vs. 4.75 +/- 2.73 mg/dL, p &lt; 0.001), urine
      retinol-binding protein (RBP 29.8 +/- 13.9 vs. 15.7 +/- 11.5 mg/dL, p = 0.005),
      and lower urinary osmotic pressure. Pathologically, patients of group 2 had a
      higher percentage of fibrous/fibrocellular crescents (66.7 +/- 21.9 vs. 47.0 +/- 
      33.6%, p = 0.037) but a lower percentage of cellular crescents. More CD8 (268
      mm(-2) vs. 180 mm(-2), p = 0.045) and CD68 (268 mm(-2) vs. 180 mm(-2), p = 0.045)
      positive cells infiltrating the interstitium were observed in group 2.
      Furthermore, renal MCs correlated significantly with the total number of
      crescents and the tubular interstitial CD8 and CD68 positive cells. And, the
      number of MCs was associated with the histological types. The renal function was 
      significantly different between the two groups at presentation. However, at 3 and
      6 month follow-up, the patient outcome was associated with the histological
      types. Our study showed that MC infiltrations were associated with chronic
      lesions in anti-GBM nephritis and may be involved in the loss of renal function
      with pathological changes.
FAU - Wu, Xiao-Mei
AU  - Wu XM
AD  - a National Clinical Research Center of Kidney Diseases , Jinling Hospital,
      Nanjing University School of Medicine , Nanjing , Jiangsu , P.R. China.
FAU - Zhang, Yi-Yan
AU  - Zhang YY
AD  - a National Clinical Research Center of Kidney Diseases , Jinling Hospital,
      Nanjing University School of Medicine , Nanjing , Jiangsu , P.R. China.
FAU - Zhang, Ming-Chao
AU  - Zhang MC
AD  - a National Clinical Research Center of Kidney Diseases , Jinling Hospital,
      Nanjing University School of Medicine , Nanjing , Jiangsu , P.R. China.
FAU - Zhang, Li-Hua
AU  - Zhang LH
AD  - a National Clinical Research Center of Kidney Diseases , Jinling Hospital,
      Nanjing University School of Medicine , Nanjing , Jiangsu , P.R. China.
FAU - Zeng, Cai-Hong
AU  - Zeng CH
AD  - a National Clinical Research Center of Kidney Diseases , Jinling Hospital,
      Nanjing University School of Medicine , Nanjing , Jiangsu , P.R. China.
FAU - Liu, Zhi-Hong
AU  - Liu ZH
AD  - a National Clinical Research Center of Kidney Diseases , Jinling Hospital,
      Nanjing University School of Medicine , Nanjing , Jiangsu , P.R. China.
FAU - Tang, Zheng
AU  - Tang Z
AD  - a National Clinical Research Center of Kidney Diseases , Jinling Hospital,
      Nanjing University School of Medicine , Nanjing , Jiangsu , P.R. China.
LA  - eng
PT  - Journal Article
DEP - 20160420
PL  - England
TA  - Ren Fail
JT  - Renal failure
JID - 8701128
SB  - IM
OTO - NOTNLM
OT  - Anti-GBM nephritis
OT  - chronic inflammation
OT  - chronic lesions
OT  - mast cells
OT  - renal function
EDAT- 2016/04/21 06:00
MHDA- 2016/04/21 06:00
CRDT- 2016/04/21 06:00
PHST- 2016/04/20 [aheadofprint]
AID - 10.3109/0886022X.2016.1164184 [doi]
PST - ppublish
SO  - Ren Fail. 2016 Jul;38(6):906-13. doi: 10.3109/0886022X.2016.1164184. Epub 2016
      Apr 20.
TY  - JOUR
AU  - Wu, Xiao-Mei
AU  - Zhang, Yi-Yan
AU  - Zhang, Ming-Chao
AU  - Zhang, Li-Hua
AU  - Zeng, Cai-Hong
AU  - Liu, Zhi-Hong
AU  - Tang, Zheng
PY  - 2016/Jul/20
TI  - Significance of mast cell renal infiltration in patients with anti-GBM nephritis.
T2  - Ren Fail
JO  - Renal failure
SP  - 906
EP  - 913
VL  - 38
IS  - 6
N2  - To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs?<50?mm(-2), n?=?18) and group 2 (MCs??50?mm(-2), n?=?20) according to the infiltrating renal MC count. The clinical-pathological indices were compared. And, correlation between MCs and the clinical-pathological indices was analyzed. Patients of group 2 had more severe renal dysfunctions, expressed as higher levels of serum creatinine (SCr 8.95???3.66 vs. 4.75???2.73?mg/dL, p?<?0.001), urine retinol-binding protein (RBP 29.8???13.9 vs. 15.7???11.5?mg/dL, p?=?0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7???21.9 vs. 47.0???33.6%, p?=?0.037) but a lower percentage of cellular crescents. More CD8 (268?mm(-2) vs. 180?mm(-2), p?=?0.045) and CD68 (268?mm(-2) vs. 180?mm(-2), p?=?0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes.
SN  - 1525-6049
UR  - http://dx.doi.org/10.3109/0886022X.2016.1164184
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27095326
ID  - Wu2016
ER  - 
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<b:Title>Significance of mast cell renal infiltration in patients with anti-GBM nephritis.</b:Title>
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<b:Comments>To investigate the role of mast cells (MCs) renal infiltration in the progression of human anti-GBM nephritis, 38 patients diagnosed with anti-GBM nephritis were enrolled. Renal biopsies were performed. Immunohistochemistry was conducted to detect MCs in renal tissues. Patients were divided into group 1 (MCs&#8201;&lt;50&#8201;mm(-2), n&#8201;=&#8201;18) and group 2 (MCs&#8201;&#8805;50&#8201;mm(-2), n&#8201;=&#8201;20) according to the infiltrating renal MC count. The clinical-pathological indices were compared. And, correlation between MCs and the clinical-pathological indices was analyzed. Patients of group 2 had more severe renal dysfunctions, expressed as higher levels of serum creatinine (SCr 8.95&#8201;&#177;&#8201;3.66 vs. 4.75&#8201;&#177;&#8201;2.73&#8201;mg/dL, p&#8201;&lt;&#8201;0.001), urine retinol-binding protein (RBP 29.8&#8201;&#177;&#8201;13.9 vs. 15.7&#8201;&#177;&#8201;11.5&#8201;mg/dL, p&#8201;=&#8201;0.005), and lower urinary osmotic pressure. Pathologically, patients of group 2 had a higher percentage of fibrous/fibrocellular crescents (66.7&#8201;&#177;&#8201;21.9 vs. 47.0&#8201;&#177;&#8201;33.6%, p&#8201;=&#8201;0.037) but a lower percentage of cellular crescents. More CD8 (268&#8201;mm(-2) vs. 180&#8201;mm(-2), p&#8201;=&#8201;0.045) and CD68 (268&#8201;mm(-2) vs. 180&#8201;mm(-2), p&#8201;=&#8201;0.045) positive cells infiltrating the interstitium were observed in group 2. Furthermore, renal MCs correlated significantly with the total number of crescents and the tubular interstitial CD8 and CD68 positive cells. And, the number of MCs was associated with the histological types. The renal function was significantly different between the two groups at presentation. However, at 3 and 6 month follow-up, the patient outcome was associated with the histological types. Our study showed that MC infiltrations were associated with chronic lesions in anti-GBM nephritis and may be involved in the loss of renal function with pathological changes.</b:Comments>
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