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Multidimensional assessment of self-reported chemical intolerance and its impact on chemosensory effects during ammonia exposure.

Abstract Healthy individuals differ in self-reported chemical intolerance (CI). It is unclear whether this inter-individual variability impacts well-being and performance in environmental and occupational settings with chemical exposures. So far, operational definitions and questionnaires of CI have either emphasized physical symptoms or affective/behavioral disruption. In contrast, this study focused on healthy individuals who reported strong CI which generalized to awareness, physiology, affect, and behavior. We investigated whether generalized self-reported CI is associated with hyper-reactivity and reduced cognitive functioning due to chemosensory-mediated distraction during ammonia exposure.
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Authors

Mayor MeshTerms
Keywords

Cytokine

Fatty acid

Multiple chemical sensitivity

Nasal lavage

Olfaction

Journal Title international archives of occupational and environmental health
Publication Year Start
%A Pacharra, Marlene; Kleinbeck, Stefan; Sch?per, Michael; Blaszkewicz, Meinolf; van Thriel, Christoph
%T Multidimensional assessment of self-reported chemical intolerance and its impact on chemosensory effects during ammonia exposure.
%J International archives of occupational and environmental health, vol. 89, no. 6, pp. 947-959
%D 08/2016
%V 89
%N 6
%M eng
%B Healthy individuals differ in self-reported chemical intolerance (CI). It is unclear whether this inter-individual variability impacts well-being and performance in environmental and occupational settings with chemical exposures. So far, operational definitions and questionnaires of CI have either emphasized physical symptoms or affective/behavioral disruption. In contrast, this study focused on healthy individuals who reported strong CI which generalized to awareness, physiology, affect, and behavior. We investigated whether generalized self-reported CI is associated with hyper-reactivity and reduced cognitive functioning due to chemosensory-mediated distraction during ammonia exposure.
%P 947
%L 959
%Y 10.1007/s00420-016-1134-6
%W PHY
%G AUTHOR
%R 2016.......89..947P

@Article{Pacharra2016,
author="Pacharra, Marlene
and Kleinbeck, Stefan
and Sch{\"a}per, Michael
and Blaszkewicz, Meinolf
and van Thriel, Christoph",
title="Multidimensional assessment of self-reported chemical intolerance and its impact on chemosensory effects during ammonia exposure.",
journal="International archives of occupational and environmental health",
year="2016",
month="Aug",
day="28",
volume="89",
number="6",
pages="947--959",
abstract="Healthy individuals differ in self-reported chemical intolerance (CI). It is unclear whether this inter-individual variability impacts well-being and performance in environmental and occupational settings with chemical exposures. So far, operational definitions and questionnaires of CI have either emphasized physical symptoms or affective/behavioral disruption. In contrast, this study focused on healthy individuals who reported strong CI which generalized to awareness, physiology, affect, and behavior. We investigated whether generalized self-reported CI is associated with hyper-reactivity and reduced cognitive functioning due to chemosensory-mediated distraction during ammonia exposure.",
issn="1432-1246",
doi="10.1007/s00420-016-1134-6",
url="http://www.ncbi.nlm.nih.gov/pubmed/27126704",
language="eng"
}


PT Journal
AU Pacharra, M
   Kleinbeck, S
   Sch?per, M
   Blaszkewicz, M
   van Thriel, C
TI Multidimensional assessment of self-reported chemical intolerance and its impact on chemosensory effects during ammonia exposure.
SO International archives of occupational and environmental health
JI Int Arch Occup Environ Health
PD Aug
PY 2016
BP 947
EP 959
VL 89
IS 6
DI 10.1007/s00420-016-1134-6
LA eng
AB Healthy individuals differ in self-reported chemical intolerance (CI). It is unclear whether this inter-individual variability impacts well-being and performance in environmental and occupational settings with chemical exposures. So far, operational definitions and questionnaires of CI have either emphasized physical symptoms or affective/behavioral disruption. In contrast, this study focused on healthy individuals who reported strong CI which generalized to awareness, physiology, affect, and behavior. We investigated whether generalized self-reported CI is associated with hyper-reactivity and reduced cognitive functioning due to chemosensory-mediated distraction during ammonia exposure.
ER

PMID- 27126704
OWN - NLM
STAT- In-Data-Review
DA  - 20160630
IS  - 1432-1246 (Electronic)
IS  - 0340-0131 (Linking)
VI  - 89
IP  - 6
DP  - 2016 Aug
TI  - Multidimensional assessment of self-reported chemical intolerance and its impact 
      on chemosensory effects during ammonia exposure.
PG  - 947-59
LID - 10.1007/s00420-016-1134-6 [doi]
AB  - PURPOSE: Healthy individuals differ in self-reported chemical intolerance (CI).
      It is unclear whether this inter-individual variability impacts well-being and
      performance in environmental and occupational settings with chemical exposures.
      So far, operational definitions and questionnaires of CI have either emphasized
      physical symptoms or affective/behavioral disruption. In contrast, this study
      focused on healthy individuals who reported strong CI which generalized to
      awareness, physiology, affect, and behavior. We investigated whether generalized 
      self-reported CI is associated with hyper-reactivity and reduced cognitive
      functioning due to chemosensory-mediated distraction during ammonia exposure.
      METHODS: An online sample (N = 321) answered established CI questionnaires. Based
      on the convergent self-reports in these questionnaires, healthy women with
      generalized CI and healthy female control participants were selected (total N =
      26). Baseline characterization was performed using implicit association, lung and
      olfactory function tests, health-related self-reports, plasma inflammatory and
      metabolic markers. Performance in neurobehavioral tasks, perceptual ratings,
      nasal inflammatory, neuroendocrine, and autonomic nervous system reactivity were 
      examined by means of a 75-min whole-body challenge to ammonia (stepwise increase:
      0-10 ppm). RESULTS: Correlational analyses confirmed the multidimensionality of
      CI. Participants with generalized self-reported CI exhibited better olfactory
      function and reported stronger pungency during the challenge than controls.
      Cognitive performance and physiological response to the challenge were comparable
      between the two groups. CONCLUSIONS: Self-reports of CI are complex and not
      easily assessed by unidimensional questionnaires. While generalized self-reported
      CI is associated with altered chemosensory processing, it seems unlikely that it 
      modulates health effects and cognitive functioning during chemical exposure.
FAU - Pacharra, Marlene
AU  - Pacharra M
AD  - Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund 
      University, Ardeystrasse 67, 44139, Dortmund, Germany. [email protected]
FAU - Kleinbeck, Stefan
AU  - Kleinbeck S
AD  - Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund 
      University, Ardeystrasse 67, 44139, Dortmund, Germany.
FAU - Schaper, Michael
AU  - Schaper M
AD  - Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund 
      University, Ardeystrasse 67, 44139, Dortmund, Germany.
FAU - Blaszkewicz, Meinolf
AU  - Blaszkewicz M
AD  - Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund 
      University, Ardeystrasse 67, 44139, Dortmund, Germany.
FAU - van Thriel, Christoph
AU  - van Thriel C
AD  - Leibniz Research Centre for Working Environment and Human Factors at TU Dortmund 
      University, Ardeystrasse 67, 44139, Dortmund, Germany.
LA  - eng
PT  - Journal Article
DEP - 20160428
PL  - Germany
TA  - Int Arch Occup Environ Health
JT  - International archives of occupational and environmental health
JID - 7512134
SB  - IM
OTO - NOTNLM
OT  - Cytokine
OT  - Fatty acid
OT  - Multiple chemical sensitivity
OT  - Nasal lavage
OT  - Olfaction
EDAT- 2016/04/30 06:00
MHDA- 2016/04/30 06:00
CRDT- 2016/04/30 06:00
PHST- 2015/09/25 [received]
PHST- 2016/04/21 [accepted]
PHST- 2016/04/28 [aheadofprint]
AID - 10.1007/s00420-016-1134-6 [doi]
AID - 10.1007/s00420-016-1134-6 [pii]
PST - ppublish
SO  - Int Arch Occup Environ Health. 2016 Aug;89(6):947-59. doi:
      10.1007/s00420-016-1134-6. Epub 2016 Apr 28.
TY  - JOUR
AU  - Pacharra, Marlene
AU  - Kleinbeck, Stefan
AU  - Sch?per, Michael
AU  - Blaszkewicz, Meinolf
AU  - van Thriel, Christoph
PY  - 2016/Aug/28
TI  - Multidimensional assessment of self-reported chemical intolerance and its impact on chemosensory effects during ammonia exposure.
T2  - Int Arch Occup Environ Health
JO  - International archives of occupational and environmental health
SP  - 947
EP  - 959
VL  - 89
IS  - 6
N2  - Healthy individuals differ in self-reported chemical intolerance (CI). It is unclear whether this inter-individual variability impacts well-being and performance in environmental and occupational settings with chemical exposures. So far, operational definitions and questionnaires of CI have either emphasized physical symptoms or affective/behavioral disruption. In contrast, this study focused on healthy individuals who reported strong CI which generalized to awareness, physiology, affect, and behavior. We investigated whether generalized self-reported CI is associated with hyper-reactivity and reduced cognitive functioning due to chemosensory-mediated distraction during ammonia exposure.
SN  - 1432-1246
UR  - http://dx.doi.org/10.1007/s00420-016-1134-6
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27126704
ID  - Pacharra2016
ER  - 
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