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Long-term effect of heavy-metal pollution on diversity of gastrointestinal microbial community of Bufo raddei.

Abstract Gastrointestinal (GI) microbiota plays a very important role in maintaining its host's health. However, the effects of environmental contamination on the GI microbiota homeostasis of amphibians have not yet been reported. The present study reveals the long-term effect of natural heavy-metal pollution on the GI microbial community diversity and structural changes of Bufo raddei (B. raddei). Basing on the 16S rRNA sequencing method, the GI microbiota of B. raddei from a heavily heavy-metal-polluted area (Baiyin, (BY)) and a relatively unpolluted area (Liujiaxia, (LJX)) were profiled. The results showed that heavy-metal pollution had caused significant shifts in the composition of the GI microbiota both at the phylum and genus levels. Specifically, Bacteroidetes dominated in the GI tract of B. raddei from BY, while Tenericutes was much more common in those from LJX. The ratio of Firmicutes/Bacteroidetes and the proportion of probiotics in the GI microbiota of B. raddei from BY were reduced compared to those from LJX, as well. Heavy-metal pollution also induced in a reduction of species diversity and decreased proportion of unique operational taxonomic units in the GI tract. In short, our results demonstrate that long-term heavy-metal exposure re-shaped the composition and decreased the species diversity of GI microbiota of B. raddei; our results also represent a novel approach to uncover the toxic effects of pollution on amphibians.
PMID
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Authors

Mayor MeshTerms
Keywords

16S rRNA

Amphibian

Diversity

Homeostasis

Intestinal microflora

Journal Title toxicology letters
Publication Year Start
%A Zhang, Wenya; Guo, Rui; Yang, Ying; Ding, Jian; Zhang, Yingmei
%T Long-term effect of heavy-metal pollution on diversity of gastrointestinal microbial community of Bufo raddei.
%J Toxicology letters, vol. 258, pp. 192-197
%D 07/2016
%V 258
%M ENG
%B Gastrointestinal (GI) microbiota plays a very important role in maintaining its host's health. However, the effects of environmental contamination on the GI microbiota homeostasis of amphibians have not yet been reported. The present study reveals the long-term effect of natural heavy-metal pollution on the GI microbial community diversity and structural changes of Bufo raddei (B. raddei). Basing on the 16S rRNA sequencing method, the GI microbiota of B. raddei from a heavily heavy-metal-polluted area (Baiyin, (BY)) and a relatively unpolluted area (Liujiaxia, (LJX)) were profiled. The results showed that heavy-metal pollution had caused significant shifts in the composition of the GI microbiota both at the phylum and genus levels. Specifically, Bacteroidetes dominated in the GI tract of B. raddei from BY, while Tenericutes was much more common in those from LJX. The ratio of Firmicutes/Bacteroidetes and the proportion of probiotics in the GI microbiota of B. raddei from BY were reduced compared to those from LJX, as well. Heavy-metal pollution also induced in a reduction of species diversity and decreased proportion of unique operational taxonomic units in the GI tract. In short, our results demonstrate that long-term heavy-metal exposure re-shaped the composition and decreased the species diversity of GI microbiota of B. raddei; our results also represent a novel approach to uncover the toxic effects of pollution on amphibians.
%P 192
%L 197
%Y 10.1016/j.toxlet.2016.07.003
%W PHY
%G AUTHOR
%R 2016......258..192Z

@Article{Zhang2016,
author="Zhang, Wenya
and Guo, Rui
and Yang, Ying
and Ding, Jian
and Zhang, Yingmei",
title="Long-term effect of heavy-metal pollution on diversity of gastrointestinal microbial community of Bufo raddei.",
journal="Toxicology letters",
year="2016",
month="Jul",
day="05",
volume="258",
pages="192--197",
abstract="Gastrointestinal (GI) microbiota plays a very important role in maintaining its host's health. However, the effects of environmental contamination on the GI microbiota homeostasis of amphibians have not yet been reported. The present study reveals the long-term effect of natural heavy-metal pollution on the GI microbial community diversity and structural changes of Bufo raddei (B. raddei). Basing on the 16S rRNA sequencing method, the GI microbiota of B. raddei from a heavily heavy-metal-polluted area (Baiyin, (BY)) and a relatively unpolluted area (Liujiaxia, (LJX)) were profiled. The results showed that heavy-metal pollution had caused significant shifts in the composition of the GI microbiota both at the phylum and genus levels. Specifically, Bacteroidetes dominated in the GI tract of B. raddei from BY, while Tenericutes was much more common in those from LJX. The ratio of Firmicutes/Bacteroidetes and the proportion of probiotics in the GI microbiota of B. raddei from BY were reduced compared to those from LJX, as well. Heavy-metal pollution also induced in a reduction of species diversity and decreased proportion of unique operational taxonomic units in the GI tract. In short, our results demonstrate that long-term heavy-metal exposure re-shaped the composition and decreased the species diversity of GI microbiota of B. raddei; our results also represent a novel approach to uncover the toxic effects of pollution on amphibians.",
issn="1879-3169",
doi="10.1016/j.toxlet.2016.07.003",
url="http://www.ncbi.nlm.nih.gov/pubmed/27392436",
language="ENG"
}

%0 Journal Article
%T Long-term effect of heavy-metal pollution on diversity of gastrointestinal microbial community of Bufo raddei.
%A Zhang, Wenya
%A Guo, Rui
%A Yang, Ying
%A Ding, Jian
%A Zhang, Yingmei
%J Toxicology letters
%D 2016
%8 Jul 05
%V 258
%@ 1879-3169
%G ENG
%F Zhang2016
%X Gastrointestinal (GI) microbiota plays a very important role in maintaining its host's health. However, the effects of environmental contamination on the GI microbiota homeostasis of amphibians have not yet been reported. The present study reveals the long-term effect of natural heavy-metal pollution on the GI microbial community diversity and structural changes of Bufo raddei (B. raddei). Basing on the 16S rRNA sequencing method, the GI microbiota of B. raddei from a heavily heavy-metal-polluted area (Baiyin, (BY)) and a relatively unpolluted area (Liujiaxia, (LJX)) were profiled. The results showed that heavy-metal pollution had caused significant shifts in the composition of the GI microbiota both at the phylum and genus levels. Specifically, Bacteroidetes dominated in the GI tract of B. raddei from BY, while Tenericutes was much more common in those from LJX. The ratio of Firmicutes/Bacteroidetes and the proportion of probiotics in the GI microbiota of B. raddei from BY were reduced compared to those from LJX, as well. Heavy-metal pollution also induced in a reduction of species diversity and decreased proportion of unique operational taxonomic units in the GI tract. In short, our results demonstrate that long-term heavy-metal exposure re-shaped the composition and decreased the species diversity of GI microbiota of B. raddei; our results also represent a novel approach to uncover the toxic effects of pollution on amphibians.
%U http://dx.doi.org/10.1016/j.toxlet.2016.07.003
%U http://www.ncbi.nlm.nih.gov/pubmed/27392436
%P 192-197

PT Journal
AU Zhang, W
   Guo, R
   Yang, Y
   Ding, J
   Zhang, Y
TI Long-term effect of heavy-metal pollution on diversity of gastrointestinal microbial community of Bufo raddei.
SO Toxicology letters
JI Toxicol. Lett.
PD Jul
PY 2016
BP 192
EP 197
VL 258
DI 10.1016/j.toxlet.2016.07.003
LA ENG
AB Gastrointestinal (GI) microbiota plays a very important role in maintaining its host's health. However, the effects of environmental contamination on the GI microbiota homeostasis of amphibians have not yet been reported. The present study reveals the long-term effect of natural heavy-metal pollution on the GI microbial community diversity and structural changes of Bufo raddei (B. raddei). Basing on the 16S rRNA sequencing method, the GI microbiota of B. raddei from a heavily heavy-metal-polluted area (Baiyin, (BY)) and a relatively unpolluted area (Liujiaxia, (LJX)) were profiled. The results showed that heavy-metal pollution had caused significant shifts in the composition of the GI microbiota both at the phylum and genus levels. Specifically, Bacteroidetes dominated in the GI tract of B. raddei from BY, while Tenericutes was much more common in those from LJX. The ratio of Firmicutes/Bacteroidetes and the proportion of probiotics in the GI microbiota of B. raddei from BY were reduced compared to those from LJX, as well. Heavy-metal pollution also induced in a reduction of species diversity and decreased proportion of unique operational taxonomic units in the GI tract. In short, our results demonstrate that long-term heavy-metal exposure re-shaped the composition and decreased the species diversity of GI microbiota of B. raddei; our results also represent a novel approach to uncover the toxic effects of pollution on amphibians.
ER

PMID- 27392436
OWN - NLM
STAT- Publisher
DA  - 20160726
LR  - 20160726
IS  - 1879-3169 (Electronic)
IS  - 0378-4274 (Linking)
VI  - 258
DP  - 2016 Jul 5
TI  - Long-term effect of heavy-metal pollution on diversity of gastrointestinal
      microbial community of Bufo raddei.
PG  - 192-197
LID - S0378-4274(16)32266-4 [pii]
LID - 10.1016/j.toxlet.2016.07.003 [doi]
AB  - Gastrointestinal (GI) microbiota plays a very important role in maintaining its
      host's health. However, the effects of environmental contamination on the GI
      microbiota homeostasis of amphibians have not yet been reported. The present
      study reveals the long-term effect of natural heavy-metal pollution on the GI
      microbial community diversity and structural changes of Bufo raddei (B. raddei). 
      Basing on the 16S rRNA sequencing method, the GI microbiota of B. raddei from a
      heavily heavy-metal-polluted area (Baiyin, (BY)) and a relatively unpolluted area
      (Liujiaxia, (LJX)) were profiled. The results showed that heavy-metal pollution
      had caused significant shifts in the composition of the GI microbiota both at the
      phylum and genus levels. Specifically, Bacteroidetes dominated in the GI tract of
      B. raddei from BY, while Tenericutes was much more common in those from LJX. The 
      ratio of Firmicutes/Bacteroidetes and the proportion of probiotics in the GI
      microbiota of B. raddei from BY were reduced compared to those from LJX, as well.
      Heavy-metal pollution also induced in a reduction of species diversity and
      decreased proportion of unique operational taxonomic units in the GI tract. In
      short, our results demonstrate that long-term heavy-metal exposure re-shaped the 
      composition and decreased the species diversity of GI microbiota of B. raddei;
      our results also represent a novel approach to uncover the toxic effects of
      pollution on amphibians.
CI  - Copyright (c) 2016 Elsevier Ireland Ltd. All rights reserved.
FAU - Zhang, Wenya
AU  - Zhang W
AD  - Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental
      Pollution, School of Life Sciences, Lanzhou University, Lanzhou, PR China.
FAU - Guo, Rui
AU  - Guo R
AD  - Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental
      Pollution, School of Life Sciences, Lanzhou University, Lanzhou, PR China.
FAU - Yang, Ying
AU  - Yang Y
AD  - Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental
      Pollution, School of Life Sciences, Lanzhou University, Lanzhou, PR China.
FAU - Ding, Jian
AU  - Ding J
AD  - Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental
      Pollution, School of Life Sciences, Lanzhou University, Lanzhou, PR China.
FAU - Zhang, Yingmei
AU  - Zhang Y
AD  - Gansu Key Laboratory of Biomonitoring and Bioremediation for Environmental
      Pollution, School of Life Sciences, Lanzhou University, Lanzhou, PR China.
      Electronic address: ymzhang@lzu.edu.cn.
LA  - ENG
PT  - JOURNAL ARTICLE
DEP - 20160705
TA  - Toxicol Lett
JT  - Toxicology letters
JID - 7709027
OTO - NOTNLM
OT  - 16S rRNA
OT  - Amphibian
OT  - Diversity
OT  - Homeostasis
OT  - Intestinal microflora
EDAT- 2016/07/10 06:00
MHDA- 2016/07/10 06:00
CRDT- 2016/07/10 06:00
PHST- 2016/04/06 [received]
PHST- 2016/06/27 [revised]
PHST- 2016/07/04 [accepted]
AID - S0378-4274(16)32266-4 [pii]
AID - 10.1016/j.toxlet.2016.07.003 [doi]
PST - aheadofprint
SO  - Toxicol Lett. 2016 Jul 5;258:192-197. doi: 10.1016/j.toxlet.2016.07.003.
TY  - JOUR
AU  - Zhang, Wenya
AU  - Guo, Rui
AU  - Yang, Ying
AU  - Ding, Jian
AU  - Zhang, Yingmei
PY  - 2016/Jul/05
TI  - Long-term effect of heavy-metal pollution on diversity of gastrointestinal microbial community of Bufo raddei.
T2  - Toxicol. Lett.
JO  - Toxicology letters
SP  - 192
EP  - 197
VL  - 258
N2  - Gastrointestinal (GI) microbiota plays a very important role in maintaining its host's health. However, the effects of environmental contamination on the GI microbiota homeostasis of amphibians have not yet been reported. The present study reveals the long-term effect of natural heavy-metal pollution on the GI microbial community diversity and structural changes of Bufo raddei (B. raddei). Basing on the 16S rRNA sequencing method, the GI microbiota of B. raddei from a heavily heavy-metal-polluted area (Baiyin, (BY)) and a relatively unpolluted area (Liujiaxia, (LJX)) were profiled. The results showed that heavy-metal pollution had caused significant shifts in the composition of the GI microbiota both at the phylum and genus levels. Specifically, Bacteroidetes dominated in the GI tract of B. raddei from BY, while Tenericutes was much more common in those from LJX. The ratio of Firmicutes/Bacteroidetes and the proportion of probiotics in the GI microbiota of B. raddei from BY were reduced compared to those from LJX, as well. Heavy-metal pollution also induced in a reduction of species diversity and decreased proportion of unique operational taxonomic units in the GI tract. In short, our results demonstrate that long-term heavy-metal exposure re-shaped the composition and decreased the species diversity of GI microbiota of B. raddei; our results also represent a novel approach to uncover the toxic effects of pollution on amphibians.
SN  - 1879-3169
UR  - http://dx.doi.org/10.1016/j.toxlet.2016.07.003
UR  - http://www.ncbi.nlm.nih.gov/pubmed/27392436
ID  - Zhang2016
ER  - 
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