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Oxidative signalling response to cadmium exposure.

Abstract Changes in the intracellular thiol-disulfide balance are considered major determinants in the redox status/signalling of the cell. Cellular signalling is very sensitive to both exogenous and intracellular redox status and respond to many exogenous pro-oxidative or oxidative stresses. Redox status has dual effects on upstream signalling systems and downstream transcription factors. Redox signalling pathways use ROS to transfer signals from different sources to the nucleus to regulate such functions as growth, differentiation, proliferation and apoptosis. MAPKs are activated by numerous cellular stresses and ligand-receptor bindings. An imbalance in the oxidant/antioxidant system, either resulting from excessive ROS/RNS production and/or antioxidant system impairment, leads to oxidative stress. Glutathione (GSH) is known to play a critical role in the cellular defense against unregulated oxidative stress in mammalian cells and involvement of large molecular antioxidants include classical antioxidant enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and glutathione reductase (GR). Cadmium (Cd), a potent toxic heavy metal, is a widespread environmental contaminant. It is known to cause renal dysfunction, hepatic toxicity, genotoxicity and apoptotic effects depending on the dose, route and duration of exposure.This review examines the signalling pathways and mechanisms of activation of transcription factors by Cd-induced oxidative stress thus representing an important basis for understanding the mechanisms of Cd effect on the cells.
PMID
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Authors

Mayor MeshTerms
Keywords

Cadmium

Glutathione

MAPK pathways

ROS

Redox signalling

Journal Title toxicological sciences : an official journal of the society of toxicology
Publication Year Start




PMID- 27803385
OWN - NLM
STAT- Publisher
DA  - 20161102
LR  - 20161103
IS  - 1096-0929 (Electronic)
IS  - 1096-0929 (Linking)
DP  - 2016 Nov 1
TI  - Oxidative signalling response to cadmium exposure.
LID - kfw222 [pii]
AB  - Changes in the intracellular thiol-disulfide balance are considered major
      determinants in the redox status/signalling of the cell. Cellular signalling is
      very sensitive to both exogenous and intracellular redox status and respond to
      many exogenous pro-oxidative or oxidative stresses. Redox status has dual effects
      on upstream signalling systems and downstream transcription factors. Redox
      signalling pathways use ROS to transfer signals from different sources to the
      nucleus to regulate such functions as growth, differentiation, proliferation and 
      apoptosis. MAPKs are activated by numerous cellular stresses and ligand-receptor 
      bindings. An imbalance in the oxidant/antioxidant system, either resulting from
      excessive ROS/RNS production and/or antioxidant system impairment, leads to
      oxidative stress. Glutathione (GSH) is known to play a critical role in the
      cellular defense against unregulated oxidative stress in mammalian cells and
      involvement of large molecular antioxidants include classical antioxidant
      enzymes, such as superoxide dismutase (SOD), catalase (CAT), glutathione
      peroxidase (GPx), and glutathione reductase (GR). Cadmium (Cd), a potent toxic
      heavy metal, is a widespread environmental contaminant. It is known to cause
      renal dysfunction, hepatic toxicity, genotoxicity and apoptotic effects depending
      on the dose, route and duration of exposure.This review examines the signalling
      pathways and mechanisms of activation of transcription factors by Cd-induced
      oxidative stress thus representing an important basis for understanding the
      mechanisms of Cd effect on the cells.
CI  - (c) The Author 2016. Published by Oxford University Press on behalf of the
      Society of Toxicology. All rights reserved. For permissions, please email:
      [email protected]
FAU - Nemmiche, Said
AU  - Nemmiche S
AD  - LSTPA Laboratory, Department of Biology, Faculty of SNV, University of
      Mostaganem, Mostaganem 27000, Algeria. [email protected]
      [email protected]
LA  - ENG
PT  - Journal Article
DEP - 20161101
PL  - United States
TA  - Toxicol Sci
JT  - Toxicological sciences : an official journal of the Society of Toxicology
JID - 9805461
OTO - NOTNLM
OT  - Cadmium
OT  - Glutathione
OT  - MAPK pathways
OT  - ROS
OT  - Redox signalling
EDAT- 2016/11/03 06:00
MHDA- 2016/11/03 06:00
CRDT- 2016/11/03 06:00
PHST- 2016/07/20 [received]
PHST- 2016/10/24 [accepted]
AID - kfw222 [pii]
AID - 10.1093/toxsci/kfw222 [doi]
PST - aheadofprint
SO  - Toxicol Sci. 2016 Nov 1. pii: kfw222.

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