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Noise sensitivity and hyperacusis in patients affected by multiple chemical sensitivity.

Abstract The aim of this study was to investigate the presence of noise sensitivity and hyperacusis in patients suffering from multiple chemical sensitivity (MCS), a chronic condition characterized by several symptoms following low-level chemical exposure. Moreover, distortion product otoacoustic emissions (DPOAE) were performed to further study cochlear function.
PMID
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Authors

Mayor MeshTerms

Multiple Chemical Sensitivity

Keywords

Distortion product otoacoustic emissions

Hyperacusis

Idiopathic environmental intolerance

Multiple chemical sensitivity

Noise sensitivity

Journal Title international archives of occupational and environmental health
Publication Year Start




PMID- 27838888
OWN - NLM
STAT- MEDLINE
DA  - 20161113
DCOM- 20170711
LR  - 20170713
IS  - 1432-1246 (Electronic)
IS  - 0340-0131 (Linking)
VI  - 90
IP  - 2
DP  - 2017 Feb
TI  - Noise sensitivity and hyperacusis in patients affected by multiple chemical
      sensitivity.
PG  - 189-196
LID - 10.1007/s00420-016-1185-8 [doi]
AB  - PURPOSE: The aim of this study was to investigate the presence of noise
      sensitivity and hyperacusis in patients suffering from multiple chemical
      sensitivity (MCS), a chronic condition characterized by several symptoms
      following low-level chemical exposure. Moreover, distortion product otoacoustic
      emissions (DPOAE) were performed to further study cochlear function. METHODS: A
      questionnaire-based survey was performed. Eighteen MCS patients, selected with
      strict diagnostic criteria, and 20 healthy age- and gender-matched subjects
      filled Weinstein's Noise Sensitivity Questionnaire (WNS) and Khalfa's Hyperacusis
      Questionnaire (HQ). Results were compared with scores from the quick
      Environmental Exposure Sensitivity Index (qEESI), a routinarily used
      questionnaire to screen MCS symptoms, and with DPOAE values. An analysis of
      variance (ANOVA) was performed between MCS and control subjects scores; moreover,
      Spearman's rank correlation test was performed between questionnaire results.
      RESULTS: ANOVA testing on DPOAE values showed any significant difference between 
      groups, while WNS, HQ and qEESI scores were significantly higher in MCS group
      compared to controls. Correlation analysis showed strong positive correlation
      between WNS, HQ and qEESI in MCS subjects. CONCLUSIONS: For the first time,
      auditory-related perceptual disorders were studied in MCS. A strong association
      between WNS, HQ results and MCS symptoms severity has been highlighted. These
      findings suggest that decreased sound tolerance and noise sensitivity could be
      considered as possible new aspects of this syndrome, contributing to its peculiar
      phenotype. Furthermore, as DPOAE values did not differ from healthy subjects,
      present findings might suggest a 'central' source for such disorders in this
      group of patients.
FAU - Viziano, Andrea
AU  - Viziano A
AD  - Department of Clinical Sciences and Translational Medicine, 'Tor Vergata'
      University, Via Montpellier, 1, E sud Tower, 00133, Rome, Italy.
FAU - Micarelli, Alessandro
AU  - Micarelli A
AD  - Department of Clinical Sciences and Translational Medicine, 'Tor Vergata'
      University, Via Montpellier, 1, E sud Tower, 00133, Rome, Italy.
      [email protected]
AD  - Department of Systems Medicine - Neuroscience Unit, 'Tor Vergata' University,
      Rome, Italy. [email protected]
FAU - Alessandrini, Marco
AU  - Alessandrini M
AD  - Department of Clinical Sciences and Translational Medicine, 'Tor Vergata'
      University, Via Montpellier, 1, E sud Tower, 00133, Rome, Italy.
LA  - eng
PT  - Journal Article
DEP - 20161112
PL  - Germany
TA  - Int Arch Occup Environ Health
JT  - International archives of occupational and environmental health
JID - 7512134
SB  - IM
MH  - Adult
MH  - Female
MH  - Humans
MH  - Hyperacusis/*epidemiology
MH  - Male
MH  - Middle Aged
MH  - *Multiple Chemical Sensitivity
MH  - Noise/*adverse effects
MH  - Otoacoustic Emissions, Spontaneous/physiology
MH  - Surveys and Questionnaires
OTO - NOTNLM
OT  - Distortion product otoacoustic emissions
OT  - Hyperacusis
OT  - Idiopathic environmental intolerance
OT  - Multiple chemical sensitivity
OT  - Noise sensitivity
EDAT- 2016/11/14 06:00
MHDA- 2017/07/14 06:00
CRDT- 2016/11/14 06:00
PHST- 2016/05/01 [received]
PHST- 2016/11/02 [accepted]
AID - 10.1007/s00420-016-1185-8 [doi]
AID - 10.1007/s00420-016-1185-8 [pii]
PST - ppublish
SO  - Int Arch Occup Environ Health. 2017 Feb;90(2):189-196. doi:
      10.1007/s00420-016-1185-8. Epub 2016 Nov 12.