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Association between Genetic Variants of Transforming Growth Factor-β1 and Susceptibility of Pneumoconiosis: A Meta-analysis.

Abstract Transforming growth factor-beta 1 (TGF-β1) and gene variants have been extensively studied in various human diseases. For example, TGF-β1 polymorphisms were associated with fibrosis and pneumoconiosis, but the data remained controversial. The aim of this meta-analysis was to assess the association between TGF-β1 -509 C>T [rs1800469], +869 T>C [rs1800470], and +915 G>C [rs1800471] polymorphisms and pneumoconiosis.
PMID
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Authors

Mayor MeshTerms
Keywords
Journal Title chinese medical journal
Publication Year Start




PMID- 28139521
OWN - NLM
STAT- MEDLINE
DA  - 20170131
DCOM- 20170320
LR  - 20170320
IS  - 0366-6999 (Print)
IS  - 0366-6999 (Linking)
VI  - 130
IP  - 3
DP  - 2017 5th Feb
TI  - Association between Genetic Variants of Transforming Growth Factor-beta1 and
      Susceptibility of Pneumoconiosis: A Meta-analysis.
PG  - 357-364
LID - 10.4103/0366-6999.198917 [doi]
AB  - BACKGROUND: Transforming growth factor-beta 1 (TGF-beta1) and gene variants have 
      been extensively studied in various human diseases. For example, TGF-beta1
      polymorphisms were associated with fibrosis and pneumoconiosis, but the data
      remained controversial. The aim of this meta-analysis was to assess the
      association between TGF-beta1 -509 C>T [rs1800469], +869 T>C [rs1800470], and
      +915 G>C [rs1800471] polymorphisms and pneumoconiosis. METHODS: A comprehensive
      literature search was conducted through searching in PubMed, Embase, the Chinese 
      Biomedical Database, and the Wei Pu (Chinese) Database by the end of April 2016. 
      Eleven publications with 21 studies were included in this meta-analysis, covering
      a total of 4333 patients with pneumoconiosis and 3478 controls. Study quality was
      assessed, and heterogeneity and publication bias were measured. All statistical
      analyses were performed using STATA version 12.0 (StataCorp, College Station, TX,
      USA) software. RESULTS: The data showed significant associations between
      TGF-beta1 -509 C>T polymorphism and the risk of pneumoconiosis development (T vs.
      C, odds ratio [OR] = 1.35, 95% confidence interval [CI]: 1.00-1.81, P = 0.046);
      between TGF-beta1 +915 G>C polymorphism and the pneumoconiosis risk (C vs. G, OR 
      = 1.69, 95% CI: 1.19-2.40, P = 0.004; CG vs. GG, OR = 1.79, 95% CI: 1.23-2.60, P 
      = 0.002; CC+CG vs. GG, OR = 1.80, 95% CI: 1.24-2.61, P = 0.002). In addition, the
      subgroup analysis of ethnicity versus pneumoconiosis types indicated a
      significant association of silicosis among Asian populations but not that of coal
      workers' pneumoconiosis in Caucasian populations. In contrast, no significant
      association was exhibited between TGF-beta1 +869 T>C polymorphism and risk of
      pneumoconiosis. CONCLUSION: The polymorphisms of both TGF-beta1 -509 C>T and +915
      G>C are associated with increased risk of pneumoconiosis.
FAU - Deng, Chang-Wen
AU  - Deng CW
AD  - Department of Respiratory and Critical Care Medicine, Changhai Hospital, The
      Second Military Medical University, Shanghai 200433; Department of Cell Biology
      and Stem Cell Research Center, School of Basic Medical Sciences, Peking
      University Health Science Center, Beijing 100191, China.
FAU - Zhang, Xing-Xing
AU  - Zhang XX
AD  - Department of Respiratory and Critical Care Medicine, Changhai Hospital, The
      Second Military Medical University, Shanghai 200433, China.
FAU - Lin, Jin-Huan
AU  - Lin JH
AD  - Department of Gastroenterology, Changhai Hospital, The Second Military Medical
      University, Shanghai 200433, China.
FAU - Huang, Li-Fei
AU  - Huang LF
AD  - Department of Respiratory and Critical Care Medicine, Changhai Hospital, The
      Second Military Medical University, Shanghai 200433; Department of Respiratory,
      Haining People's Hospital, Jiaxing, Zhejiang 314400, China.
FAU - Qu, Yu-Lan
AU  - Qu YL
AD  - Department of Respiratory and Critical Care Medicine, Changhai Hospital, The
      Second Military Medical University, Shanghai 200433, China.
FAU - Bai, Chong
AU  - Bai C
AD  - Department of Respiratory and Critical Care Medicine, Changhai Hospital, The
      Second Military Medical University, Shanghai 200433, China.
LA  - eng
PT  - Journal Article
PT  - Meta-Analysis
PL  - China
TA  - Chin Med J (Engl)
JT  - Chinese medical journal
JID - 7513795
RN  - 0 (Transforming Growth Factor beta1)
SB  - IM
MH  - Asian Continental Ancestry Group
MH  - European Continental Ancestry Group
MH  - Genetic Predisposition to Disease/genetics
MH  - Genotype
MH  - Humans
MH  - Pneumoconiosis/*genetics
MH  - Polymorphism, Genetic/*genetics
MH  - Transforming Growth Factor beta1/*genetics
PMC - PMC5308020
COI - There are no conflicts of interest.
EDAT- 2017/02/01 06:00
MHDA- 2017/03/21 06:00
CRDT- 2017/02/01 06:00
AID - ChinMedJ_2017_130_3_357_198917 [pii]
AID - 10.4103/0366-6999.198917 [doi]
PST - ppublish
SO  - Chin Med J (Engl). 2017 5th Feb;130(3):357-364. doi: 10.4103/0366-6999.198917.

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