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The PD-1/PD-L1 axis may be aberrantly activated in occupational cholangiocarcinoma.

Abstract An outbreak of cholangiocarcinoma in a printing company was reported in Japan, and these cases were regarded as an occupational disease (occupational cholangiocarcinoma). This study examined the expression status of programmed death-1 (PD-1) and programmed death-ligand 1 (PD-L1) in occupational cholangiocarcinoma. Immunostaining of PD-1, PD-L1, CD3, CD8, and CD163 was performed using tissue sections of occupational cholangiocarcinoma (n = 10), and the results were compared with those of control cases consisting of intrahepatic (n = 23) and extrahepatic (n = 45) cholangiocarcinoma. Carcinoma cells expressed PD-L1 in all cases of occupational cholangiocarcinoma, whereas the detection of PD-L1 expression in cholangiocarcinoma cells was limited to a low number of cases (less than 10%) in the control subjects. In cases of occupational cholangiocarcinoma, occasional PD-L1 expression was also noted in precancerous/preinvasive lesions such as biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct. Additionally, tumor-associated macrophages and tumor-infiltrating T cells expressed PD-L1 and PD-1, respectively. The number of PD-L1-positive mononuclear cells, PD-1-positive lymphocytes, and CD8-positive lymphocytes infiltrating within the tumor was significantly higher in occupational cholangiocarcinoma compared with that in control cases. These results indicate that immune escape via the PD-1/PD-L1 axis may be occurring in occupational cholangiocarcinoma.
PMID
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Authors

Mayor MeshTerms
Keywords

immune escape

multistep carcinogenesis

occupational cholangiocarcinoma

organic solvent exposure

Journal Title pathology international
Publication Year Start




PMID- 28139862
OWN - NLM
STAT- MEDLINE
DA  - 20170131
DCOM- 20170317
LR  - 20170317
IS  - 1440-1827 (Electronic)
IS  - 1320-5463 (Linking)
VI  - 67
IP  - 3
DP  - 2017 Mar
TI  - The PD-1/PD-L1 axis may be aberrantly activated in occupational
      cholangiocarcinoma.
PG  - 163-170
LID - 10.1111/pin.12511 [doi]
AB  - An outbreak of cholangiocarcinoma in a printing company was reported in Japan,
      and these cases were regarded as an occupational disease (occupational
      cholangiocarcinoma). This study examined the expression status of programmed
      death-1 (PD-1) and programmed death-ligand 1 (PD-L1) in occupational
      cholangiocarcinoma. Immunostaining of PD-1, PD-L1, CD3, CD8, and CD163 was
      performed using tissue sections of occupational cholangiocarcinoma (n = 10), and 
      the results were compared with those of control cases consisting of intrahepatic 
      (n = 23) and extrahepatic (n = 45) cholangiocarcinoma. Carcinoma cells expressed 
      PD-L1 in all cases of occupational cholangiocarcinoma, whereas the detection of
      PD-L1 expression in cholangiocarcinoma cells was limited to a low number of cases
      (less than 10%) in the control subjects. In cases of occupational
      cholangiocarcinoma, occasional PD-L1 expression was also noted in
      precancerous/preinvasive lesions such as biliary intraepithelial neoplasia and
      intraductal papillary neoplasm of the bile duct. Additionally, tumor-associated
      macrophages and tumor-infiltrating T cells expressed PD-L1 and PD-1,
      respectively. The number of PD-L1-positive mononuclear cells, PD-1-positive
      lymphocytes, and CD8-positive lymphocytes infiltrating within the tumor was
      significantly higher in occupational cholangiocarcinoma compared with that in
      control cases. These results indicate that immune escape via the PD-1/PD-L1 axis 
      may be occurring in occupational cholangiocarcinoma.
CI  - (c) 2017 Japanese Society of Pathology and John Wiley & Sons Australia, Ltd.
FAU - Sato, Yasunori
AU  - Sato Y
AD  - Department of Human Pathology, Kanazawa University Graduate School of Medicine,
      Kanazawa, Japan.
FAU - Kinoshita, Masahiko
AU  - Kinoshita M
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate
      School of Medicine, Osaka, Japan.
FAU - Takemura, Shigekazu
AU  - Takemura S
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate
      School of Medicine, Osaka, Japan.
FAU - Tanaka, Shogo
AU  - Tanaka S
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate
      School of Medicine, Osaka, Japan.
FAU - Hamano, Genya
AU  - Hamano G
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate
      School of Medicine, Osaka, Japan.
FAU - Nakamori, Shoji
AU  - Nakamori S
AD  - Department of Hepato-Biliary-Pancreatic Surgery, National Hospital Organization, 
      Osaka National Hospital, Osaka, Japan.
FAU - Fujikawa, Masahiro
AU  - Fujikawa M
AD  - Department of Surgery, Nissay Hospital, Osaka, Japan.
FAU - Sugawara, Yasuhiko
AU  - Sugawara Y
AD  - Artificial Organ & Transplantation Division, Department of Surgery, University of
      Tokyo, Tokyo, Japan.
FAU - Yamamoto, Takatsugu
AU  - Yamamoto T
AD  - Department of Surgery, Ishikiriseiki Hospital, Higashiosaka, Japan.
FAU - Arimoto, Akira
AU  - Arimoto A
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Osaka Red Cross Hospital, Osaka,
      Japan.
FAU - Yamamura, Minako
AU  - Yamamura M
AD  - Department of Human Pathology, Kanazawa University Graduate School of Medicine,
      Kanazawa, Japan.
FAU - Sasaki, Motoko
AU  - Sasaki M
AD  - Department of Human Pathology, Kanazawa University Graduate School of Medicine,
      Kanazawa, Japan.
FAU - Harada, Kenichi
AU  - Harada K
AD  - Department of Human Pathology, Kanazawa University Graduate School of Medicine,
      Kanazawa, Japan.
FAU - Nakanuma, Yasuni
AU  - Nakanuma Y
AD  - Department of Diagnostic Pathology, Fukui-ken Saiseikai Hospital, Fukui, Japan.
FAU - Kubo, Shoji
AU  - Kubo S
AD  - Department of Hepato-Biliary-Pancreatic Surgery, Osaka City University Graduate
      School of Medicine, Osaka, Japan.
LA  - eng
PT  - Journal Article
DEP - 20170131
PL  - Australia
TA  - Pathol Int
JT  - Pathology international
JID - 9431380
RN  - 0 (Antigens, CD274)
RN  - 0 (CD274 protein, human)
RN  - 0 (PDCD1 protein, human)
RN  - 0 (Programmed Cell Death 1 Receptor)
RN  - 0 (Solvents)
SB  - IM
MH  - Adult
MH  - Aged
MH  - Antigens, CD274/analysis/*biosynthesis
MH  - Apoptosis/physiology
MH  - Bile Duct Neoplasms/chemically induced/immunology/*pathology
MH  - Cholangiocarcinoma/chemically induced/immunology/*pathology
MH  - Female
MH  - Humans
MH  - Immunohistochemistry
MH  - In Situ Nick-End Labeling
MH  - Japan
MH  - Lymphocytes, Tumor-Infiltrating/immunology
MH  - Male
MH  - Middle Aged
MH  - Occupational Diseases/etiology/immunology/*pathology
MH  - Occupational Exposure/adverse effects
MH  - Precancerous Conditions/pathology
MH  - Printing
MH  - Programmed Cell Death 1 Receptor/analysis/*biosynthesis
MH  - Solvents/adverse effects
OTO - NOTNLM
OT  - immune escape
OT  - multistep carcinogenesis
OT  - occupational cholangiocarcinoma
OT  - organic solvent exposure
EDAT- 2017/02/01 06:00
MHDA- 2017/03/18 06:00
CRDT- 2017/02/01 06:00
PHST- 2016/10/14 [received]
PHST- 2017/01/08 [accepted]
AID - 10.1111/pin.12511 [doi]
PST - ppublish
SO  - Pathol Int. 2017 Mar;67(3):163-170. doi: 10.1111/pin.12511. Epub 2017 Jan 31.

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