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Impact of Different Treatment Concepts on Regional Failure in Advanced Oropharyngeal Cancer.

Abstract The management of patients with advanced oropharyngeal cancer is complex and mostly requires a multidisciplinary treatment approach. In general, organ preservation by primary concurrent radiochemotherapy (RCT), or surgery completed by adjuvant radiotherapy are established treatment strategies for these patients. However, it is unclear if primary treatment has an effect on regional tumor control. The purpose of the present study was to evaluate the regional control after different treatment concepts.
PMID
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Authors

Mayor MeshTerms
Keywords

Regional failure

oropharyngeal cancer

radiochemotherapy

transoral surgery

Journal Title anticancer research
Publication Year Start




PMID- 28179323
OWN - NLM
STAT- MEDLINE
DA  - 20170209
DCOM- 20170306
LR  - 20170306
IS  - 1791-7530 (Electronic)
IS  - 0250-7005 (Linking)
VI  - 37
IP  - 2
DP  - 2017 Feb
TI  - Impact of Different Treatment Concepts on Regional Failure in Advanced
      Oropharyngeal Cancer.
PG  - 727-734
AB  - BACKGROUND: The management of patients with advanced oropharyngeal cancer is
      complex and mostly requires a multidisciplinary treatment approach. In general,
      organ preservation by primary concurrent radiochemotherapy (RCT), or surgery
      completed by adjuvant radiotherapy are established treatment strategies for these
      patients. However, it is unclear if primary treatment has an effect on regional
      tumor control. The purpose of the present study was to evaluate the regional
      control after different treatment concepts. PATIENTS AND METHODS: Clinical data, 
      including histological and radiological results, of 82 patients with T2-T3
      oropharyngeal cancer and N2 neck were retrospectively analyzed. They underwent
      either RCT with salvage neck dissection (ND) (n=45), or primary transoral surgery
      with ND and adjuvant RCT (n=37). In all cases, the primary tumor was successfully
      treated, without evidence of local failure in the follow-up. RESULTS: Overall, 11
      (13.4%) patients developed regional failure during the follow-up. There were no
      significant differences in frequency of regional failure (p=0.75), distant
      metastasis (p=0.35) and overall survival (p=0.22) between treatment groups.
      However, 5-year disease-free survival was significantly worse (39.0% vs. 57.0%)
      for patients treated by RCT, with more frequent regional failure detected
      compared to surgically-treated patients in univariate analysis (p=0.04).
      CONCLUSION: Treatment concept does not seem to affect regional tumor control in
      advanced oropharyngeal cancer after successful treatment of the primary tumor.
CI  - Copyright(c) 2017, International Institute of Anticancer Research (Dr. George J. 
      Delinasios), All rights reserved.
FAU - Hoch, Stephan
AU  - Hoch S
AD  - Department of Otolaryngology, Head and Neck Surgery, Philipps University of
      Marburg, Marburg, Germany [email protected]
FAU - Thelen, Katharina
AU  - Thelen K
AD  - Department of Otolaryngology, Head and Neck Surgery, Philipps University of
      Marburg, Marburg, Germany.
FAU - Vorwerk, Hilke
AU  - Vorwerk H
AD  - Department of Radiotherapy and Radiooncology, Philipps University of Marburg,
      Marburg, Germany.
FAU - Netzer, Christoph
AU  - Netzer C
AD  - Department of Otolaryngology, Head and Neck Surgery, Philipps University of
      Marburg, Marburg, Germany.
FAU - Wilhelm, Thomas
AU  - Wilhelm T
AD  - Department of Otolaryngology, Head/Neck & Facial Plastic Surgery, Sana Kliniken
      Leipziger Land, Borna, Germany.
FAU - Gunzel, Thomas
AU  - Gunzel T
AD  - Department of Otolaryngology, Head and Neck Surgery, Borromaus Hospital, Leer,
      Germany.
FAU - Teymoortash, Afshin
AU  - Teymoortash A
AD  - Department of Otolaryngology, Head and Neck Surgery, Philipps University of
      Marburg, Marburg, Germany.
LA  - eng
PT  - Journal Article
PL  - Greece
TA  - Anticancer Res
JT  - Anticancer research
JID - 8102988
SB  - IM
MH  - Adult
MH  - Aged
MH  - Aged, 80 and over
MH  - Analysis of Variance
MH  - Chemoradiotherapy/methods
MH  - Combined Modality Therapy
MH  - Female
MH  - Follow-Up Studies
MH  - Humans
MH  - Kaplan-Meier Estimate
MH  - Lymphatic Metastasis
MH  - Male
MH  - Middle Aged
MH  - Neck Dissection/*methods
MH  - Oropharyngeal Neoplasms/pathology/*therapy
MH  - Outcome Assessment (Health Care)/*methods/statistics & numerical data
MH  - Retrospective Studies
MH  - Salvage Therapy/*methods
MH  - Treatment Failure
OTO - NOTNLM
OT  - Regional failure
OT  - oropharyngeal cancer
OT  - radiochemotherapy
OT  - transoral surgery
EDAT- 2017/02/10 06:00
MHDA- 2017/03/07 06:00
CRDT- 2017/02/10 06:00
PHST- 2016/11/17 [received]
PHST- 2016/12/16 [revised]
PHST- 2016/12/20 [accepted]
AID - 37/2/727 [pii]
AID - 10.21873/anticanres.11370 [doi]
PST - ppublish
SO  - Anticancer Res. 2017 Feb;37(2):727-734.

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