PubTransformer

A site to transform Pubmed publications into these bibliographic reference formats: ADS, BibTeX, EndNote, ISI used by the Web of Knowledge, RIS, MEDLINE, Microsoft's Word 2007 XML.

Expression of polysialic acid in primary laryngeal squamous cell carcinoma.

Abstract Expression of polySia is associated with metastatic dissemination and progression of various malignant diseases. In particular, it may contribute to tumorigenesis by a negative modulatory effect on cellular signaling cascades responsible for cellular migration, differentiation and proliferation. In this study, we investigated the expression of polySia in primary metastatic and non-metastatic laryngeal squamous cell carcinoma (LSCC) tumor tissues and its potential impact on the LSCC progression.
PMID
Related Publications

MiR-139 targets CXCR4 and inhibits the proliferation and metastasis of laryngeal squamous carcinoma cells.

Downregulated Chibby in laryngeal squamous cell carcinoma with increased expression in laryngeal carcinoma Hep-2 cells.

Zinc finger protein x-linked (ZFX) contributes to patient prognosis, cell proliferation and apoptosis in human laryngeal squamous cell carcinoma.

Downregulation of Notch1 induces apoptosis and inhibits cell proliferation and metastasis in laryngeal squamous cell carcinoma.

Microarray gene expression analysis of tumorigenesis and regional lymph node metastasis in laryngeal squamous cell carcinoma.

Authors

Mayor MeshTerms

Gene Expression Regulation, Neoplastic

Keywords

FGFR-MAPK/Erk1/2 signaling

Laryngeal squamous cell carcinoma

Metastases

Polysialic acid

Polysialyltransferase

Journal Title life sciences
Publication Year Start




PMID- 28185819
OWN - NLM
STAT- MEDLINE
DA  - 20170210
DCOM- 20170315
LR  - 20170315
IS  - 1879-0631 (Electronic)
IS  - 0024-3205 (Linking)
VI  - 173
DP  - 2017 Mar 15
TI  - Expression of polysialic acid in primary laryngeal squamous cell carcinoma.
PG  - 73-79
LID - S0024-3205(17)30039-5 [pii]
LID - 10.1016/j.lfs.2017.02.002 [doi]
AB  - AIMS: Expression of polySia is associated with metastatic dissemination and
      progression of various malignant diseases. In particular, it may contribute to
      tumorigenesis by a negative modulatory effect on cellular signaling cascades
      responsible for cellular migration, differentiation and proliferation. In this
      study, we investigated the expression of polySia in primary metastatic and
      non-metastatic laryngeal squamous cell carcinoma (LSCC) tumor tissues and its
      potential impact on the LSCC progression. MAIN METHODS: The expression of polySia
      in metastatic and non-metastatic primary laryngeal squamous cell carcinoma (LSCC)
      tumor biopsy specimens was investigated by immunohistochemistry, while the
      expression of polysialyltransferase IV (ST8SiaIV)(), fibroblast growth factor
      receptor 1 (FGFR1), extracellular signal regulated kinases 1 and 2 (Erk 1/2) and 
      c-Raf was tested in metastatic and non-metastatic primary tumor tissues
      (including the corresponding non-tumor control tissues) by Western blot analysis.
      KEY FINDINGS: The expression of polySia was detected in LSCC biopsies specimens
      with generally stronger immunoreactivity in non-metastatic tumor LSCC sections
      and in histologically undifferentiated tumors. Also, increased polySia expression
      was observed in adjacent histologically unaltered laryngeal tumor-associated
      tissue of the metastatic sections. In addition, we provide an evidence of
      increased polysialyltransferase IV (ST8SiaIV) expression, involved in polySia
      synthesis in both metastatic and non-metastatic primary tumors which is
      accompanied by decreased levels of FGFR1, Erk 1/2 and c-Raf. SIGNIFICANCE: We
      present for the first time the evidence for the polySia expression in LSCC
      biopsies specimens which suggests its potential impact on initial steps of LSCC
      malignant transformation.
CI  - Copyright (c) 2017 Elsevier Inc. All rights reserved.
FAU - Klobucar, Marko
AU  - Klobucar M
AD  - University of Rijeka, Department of Biotechnology, Centre of High-Throughput
      Technologies, Radmile Matejcic 2, 51000 Rijeka, Croatia.
FAU - Visentin, Sarah
AU  - Visentin S
AD  - University of Rijeka, Department of Biotechnology, Centre of High-Throughput
      Technologies, Radmile Matejcic 2, 51000 Rijeka, Croatia.
FAU - Jakovcevic, Antonija
AU  - Jakovcevic A
AD  - University Department of ENT, Head and Neck Surgery, Kispaticeva 12, 10 000
      Zagreb, Croatia.
FAU - Bilic, Mario
AU  - Bilic M
AD  - University Department of ENT, Head and Neck Surgery, Kispaticeva 12, 10 000
      Zagreb, Croatia.
FAU - Kovac-Bilic, Lana
AU  - Kovac-Bilic L
AD  - University Department of ENT, Head and Neck Surgery, Kispaticeva 12, 10 000
      Zagreb, Croatia.
FAU - Danic, Davorin
AU  - Danic D
AD  - University Josip Juraj Strossmayer of Osijek, Medical School Osijek, Department
      of ENT and Head and Neck Surgery, General Hospital "Dr. J. Bencevic", 35 000
      Slavonski Brod, Croatia.
FAU - Pavelic, Kresimir
AU  - Pavelic K
AD  - University of Rijeka, Department of Biotechnology, Centre of High-Throughput
      Technologies, Radmile Matejcic 2, 51000 Rijeka, Croatia.
FAU - Kraljevic Pavelic, Sandra
AU  - Kraljevic Pavelic S
AD  - University of Rijeka, Department of Biotechnology, Centre of High-Throughput
      Technologies, Radmile Matejcic 2, 51000 Rijeka, Croatia. Electronic address:
      [email protected]
LA  - eng
PT  - Journal Article
DEP - 20170207
PL  - Netherlands
TA  - Life Sci
JT  - Life sciences
JID - 0375521
RN  - 0 (Neoplasm Proteins)
RN  - 0 (Sialic Acids)
RN  - 0 (polysialic acid)
RN  - EC 2.4.99.- (Sialyltransferases)
RN  - EC 3.4.99.- (ST8SIA4 protein, human)
SB  - IM
MH  - Aged
MH  - Carcinoma, Squamous Cell/*metabolism/pathology
MH  - *Gene Expression Regulation, Neoplastic
MH  - Humans
MH  - Laryngeal Neoplasms/*metabolism/pathology
MH  - Male
MH  - Middle Aged
MH  - Neoplasm Metastasis
MH  - Neoplasm Proteins/biosynthesis
MH  - Sialic Acids/*biosynthesis
MH  - Sialyltransferases/biosynthesis
MH  - Tumor Cells, Cultured
OTO - NOTNLM
OT  - FGFR-MAPK/Erk1/2 signaling
OT  - Laryngeal squamous cell carcinoma
OT  - Metastases
OT  - Polysialic acid
OT  - Polysialyltransferase
EDAT- 2017/02/12 06:00
MHDA- 2017/03/16 06:00
CRDT- 2017/02/11 06:00
PHST- 2016/12/24 [received]
PHST- 2017/01/27 [revised]
PHST- 2017/02/02 [accepted]
AID - S0024-3205(17)30039-5 [pii]
AID - 10.1016/j.lfs.2017.02.002 [doi]
PST - ppublish
SO  - Life Sci. 2017 Mar 15;173:73-79. doi: 10.1016/j.lfs.2017.02.002. Epub 2017 Feb 7.

<?xml version="1.0" encoding="UTF-8"?>
<b:Sources SelectedStyle="" xmlns:b="http://schemas.openxmlformats.org/officeDocument/2006/bibliography"  xmlns="http://schemas.openxmlformats.org/officeDocument/2006/bibliography" >
</b:Sources>