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Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph after Systemic Administration.

Abstract Noise-induced hearing loss (NIHL) is a global health problem affecting over 5% of the population worldwide. We have shown previously that acute noise-induced cochlear injury can be ameliorated by administration of drugs acting on adenosine receptors in the inner ear, and a selective A1 adenosine receptor agonist adenosine amine congener (ADAC) has emerged as a potentially effective treatment for cochlear injury and resulting hearing loss. This study investigated pharmacokinetic properties of ADAC in rat perilymph after systemic (intravenous) administration using a newly developed liquid chromatography-tandem mass spectrometry detection method. The method was developed and validated in accordance with the USA FDA guidelines including accuracy, precision, specificity, and linearity. Perilymph was sampled from the apical turn of the cochlea to prevent contamination with the cerebrospinal fluid. ADAC was detected in cochlear perilymph within two minutes following intravenous administration and remained in perilymph above its minimal effective concentration for at least two hours. The pharmacokinetic pattern of ADAC was significantly altered by exposure to noise, suggesting transient changes in permeability of the blood-labyrinth barrier and/or cochlear blood flow. This study supports ADAC development as a potential clinical otological treatment for acute sensorineural hearing loss caused by exposure to traumatic noise.
PMID
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Authors

Mayor MeshTerms

Hearing Loss, Noise-Induced

Keywords
Journal Title biomed research international
Publication Year Start




PMID- 28194422
OWN - NLM
STAT- MEDLINE
DA  - 20170214
DCOM- 20170216
LR  - 20170224
IS  - 2314-6141 (Electronic)
VI  - 2017
DP  - 2017
TI  - Pharmacokinetic Properties of Adenosine Amine Congener in Cochlear Perilymph
      after Systemic Administration.
PG  - 8091462
LID - 10.1155/2017/8091462 [doi]
AB  - Noise-induced hearing loss (NIHL) is a global health problem affecting over 5% of
      the population worldwide. We have shown previously that acute noise-induced
      cochlear injury can be ameliorated by administration of drugs acting on adenosine
      receptors in the inner ear, and a selective A1 adenosine receptor agonist
      adenosine amine congener (ADAC) has emerged as a potentially effective treatment 
      for cochlear injury and resulting hearing loss. This study investigated
      pharmacokinetic properties of ADAC in rat perilymph after systemic (intravenous) 
      administration using a newly developed liquid chromatography-tandem mass
      spectrometry detection method. The method was developed and validated in
      accordance with the USA FDA guidelines including accuracy, precision,
      specificity, and linearity. Perilymph was sampled from the apical turn of the
      cochlea to prevent contamination with the cerebrospinal fluid. ADAC was detected 
      in cochlear perilymph within two minutes following intravenous administration and
      remained in perilymph above its minimal effective concentration for at least two 
      hours. The pharmacokinetic pattern of ADAC was significantly altered by exposure 
      to noise, suggesting transient changes in permeability of the blood-labyrinth
      barrier and/or cochlear blood flow. This study supports ADAC development as a
      potential clinical otological treatment for acute sensorineural hearing loss
      caused by exposure to traumatic noise.
FAU - Chang, Hao
AU  - Chang H
AUID- ORCID: 0000-0002-4893-4086
AD  - Department of Physiology and Centre for Brain Research, University of Auckland,
      Private Bag 92019, Auckland 1142, New Zealand.
FAU - Telang, Ravindra S
AU  - Telang RS
AUID- ORCID: 0000-0003-3698-6038
AD  - Department of Physiology and Centre for Brain Research, University of Auckland,
      Private Bag 92019, Auckland 1142, New Zealand.
FAU - Sreebhavan, Sreevalsan
AU  - Sreebhavan S
AD  - Auckland Cancer Research Centre, University of Auckland, Private Bag 92019,
      Auckland 1142, New Zealand.
FAU - Tingle, Malcolm
AU  - Tingle M
AUID- ORCID: 0000-0002-4443-7963
AD  - Department of Pharmacology, University of Auckland, Private Bag 92019, Auckland
      1142, New Zealand.
FAU - Thorne, Peter R
AU  - Thorne PR
AD  - Department of Physiology and Centre for Brain Research, University of Auckland,
      Private Bag 92019, Auckland 1142, New Zealand.
FAU - Vlajkovic, Srdjan M
AU  - Vlajkovic SM
AUID- ORCID: 0000-0001-8548-6844
AD  - Department of Physiology and Centre for Brain Research, University of Auckland,
      Private Bag 92019, Auckland 1142, New Zealand.
LA  - eng
PT  - Journal Article
DEP - 20170118
PL  - United States
TA  - Biomed Res Int
JT  - BioMed research international
JID - 101600173
RN  - 96760-69-9 (adenosine amine congener)
RN  - K72T3FS567 (Adenosine)
SB  - IM
MH  - Adenosine/*analogs & derivatives/pharmacokinetics/pharmacology
MH  - Animals
MH  - Cochlea/*metabolism
MH  - *Hearing Loss, Noise-Induced/drug therapy/metabolism
MH  - Male
MH  - Perilymph/*metabolism
MH  - Rats
MH  - Rats, Wistar
PMC - PMC5286489
COI - The authors declare that they have no competing interests.
EDAT- 2017/02/15 06:00
MHDA- 2017/02/17 06:00
CRDT- 2017/02/15 06:00
PHST- 2016/10/06 [received]
PHST- 2016/11/27 [accepted]
AID - 10.1155/2017/8091462 [doi]
PST - ppublish
SO  - Biomed Res Int. 2017;2017:8091462. doi: 10.1155/2017/8091462. Epub 2017 Jan 18.

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